Impact of High Preoperative Steroid Doses on Postoperative Complications among Patients on Prolonged Preoperative Steroid Therapy
[Abstract] Corticosteroids are essential to maintain the organic homeostasis. Steroid, glucocorticoid or its synthetic analog is widely used for inflammatory and autoimmune diseases. Prolonged steroid therapy is reported to cause the susceptibility to infection, impaired wound healing and psychoneur...
Gespeichert in:
| Veröffentlicht in: | FUKUOKA ACTA MEDICA 2013-12, Vol.104 (12), p.499-506 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 506 |
|---|---|
| container_issue | 12 |
| container_start_page | 499 |
| container_title | FUKUOKA ACTA MEDICA |
| container_volume | 104 |
| creator | Iguchi, Tomohiro Shirabe, Ken Inoue, Kentaro Ito, Shuhei Ohga, Takefumi Nozoe, Tadahiro Ezaki, Takahiro Yoshizumi, Tomoharu Uchiyama, Hideaki Soejima, Yuji Ikegami, Toru Yamashita, Yo-Ichi Kawanaka, Hirofumi Ikeda, Tetsuo Saeki, Hiroshi Morita, Masaru Maehara, Yoshihiko |
| description | [Abstract] Corticosteroids are essential to maintain the organic homeostasis. Steroid, glucocorticoid or its synthetic analog is widely used for inflammatory and autoimmune diseases. Prolonged steroid therapy is reported to cause the susceptibility to infection, impaired wound healing and psychoneurosis, however whether the quantity of taking the preoperative steroid is associated the postoperative complication is still unknown. The aim of this study was to elucidate whether the steroid dose in patients on prolonged preoperative steroid therapy is associated postoperative morbidity and mortality. Twenty-five patients taking steroid for various illnesses and underwent the surgery under general anesthesia were selected in this study. The mean +- standard deviation and the median of the steroid dose converted into hydrocortisone (mg/day) were 39.2 +- 31.0 and 20, respectively. Of 25 cases, postoperative complications were seen in 10 cases. The postoperative complication was severe based on the grade of Clavien and Dindo by ANOVA as the doses of taking steroid increased (p=0.0171). The grave postoperative complication classified as Clavien and Dindo grade III occurred with 100% sensitivity and 87% specificity for the steroid dose converted into hydrocortisone > 80 mg/day. Preoperative taking the large amount of steroid (> 80mg/day) could cause a grave complication. More careful selection of the operative procedure might improve the mobidity rate. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1513045931</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1513045931</sourcerecordid><originalsourceid>FETCH-LOGICAL-j285t-1a1dc610021924faff017b5302ff072cc280eed1423c6134284ae0abdb8f234a3</originalsourceid><addsrcrecordid>eNptkE9Lw0AQxXNQbKn9CrJHL4Gd2c2_o1RthYIFK3hbNsmk3TbJxmwi9Og3d6EVL57mzXs_Bt5cBVPOIQ4xkh-TYO6cyTlHhAwhvQkmKONMxEkyDb5fmk4XA7MVW5ndnm16sh31ejBfxN4G6q0p2aN15Jht2ca64S9e2KarTeEX2zqmG9vu2MZv1A5nure196j8_-p2753udBtcV7p2NL_MWfD-_LRdrML16_Jl8bAOD5hGQwgayiIG38KXkJWuKg5JHgmOXiVYFJhyohIkCo8JianUxHVe5mmFQmoxC-7Pd7vefo7kBtUYV1Bd65bs6BREILiMMgEevbugY95QqbreNLo_qd-3eWB5BnzqH-Bb1qYldbBj3_oOqjxG1XgcrUIOQnHgElBx7qXMMsUjHiMKQIjFD0iygZk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1513045931</pqid></control><display><type>article</type><title>Impact of High Preoperative Steroid Doses on Postoperative Complications among Patients on Prolonged Preoperative Steroid Therapy</title><source>MEDLINE</source><source>Freely Accessible Japanese Titles</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Iguchi, Tomohiro ; Shirabe, Ken ; Inoue, Kentaro ; Ito, Shuhei ; Ohga, Takefumi ; Nozoe, Tadahiro ; Ezaki, Takahiro ; Yoshizumi, Tomoharu ; Uchiyama, Hideaki ; Soejima, Yuji ; Ikegami, Toru ; Yamashita, Yo-Ichi ; Kawanaka, Hirofumi ; Ikeda, Tetsuo ; Saeki, Hiroshi ; Morita, Masaru ; Maehara, Yoshihiko</creator><creatorcontrib>Iguchi, Tomohiro ; Shirabe, Ken ; Inoue, Kentaro ; Ito, Shuhei ; Ohga, Takefumi ; Nozoe, Tadahiro ; Ezaki, Takahiro ; Yoshizumi, Tomoharu ; Uchiyama, Hideaki ; Soejima, Yuji ; Ikegami, Toru ; Yamashita, Yo-Ichi ; Kawanaka, Hirofumi ; Ikeda, Tetsuo ; Saeki, Hiroshi ; Morita, Masaru ; Maehara, Yoshihiko ; Department of Surgery and Science ; Fukuoka Higashi Medical Center ; Department of Surgery ; Kyushu University ; Graduate School of Medical Sciences</creatorcontrib><description>[Abstract] Corticosteroids are essential to maintain the organic homeostasis. Steroid, glucocorticoid or its synthetic analog is widely used for inflammatory and autoimmune diseases. Prolonged steroid therapy is reported to cause the susceptibility to infection, impaired wound healing and psychoneurosis, however whether the quantity of taking the preoperative steroid is associated the postoperative complication is still unknown. The aim of this study was to elucidate whether the steroid dose in patients on prolonged preoperative steroid therapy is associated postoperative morbidity and mortality. Twenty-five patients taking steroid for various illnesses and underwent the surgery under general anesthesia were selected in this study. The mean +- standard deviation and the median of the steroid dose converted into hydrocortisone (mg/day) were 39.2 +- 31.0 and 20, respectively. Of 25 cases, postoperative complications were seen in 10 cases. The postoperative complication was severe based on the grade of Clavien and Dindo by ANOVA as the doses of taking steroid increased (p=0.0171). The grave postoperative complication classified as Clavien and Dindo grade III occurred with 100% sensitivity and 87% specificity for the steroid dose converted into hydrocortisone > 80 mg/day. Preoperative taking the large amount of steroid (> 80mg/day) could cause a grave complication. More careful selection of the operative procedure might improve the mobidity rate.</description><identifier>ISSN: 0016-254X</identifier><identifier>PMID: 24693677</identifier><language>eng</language><publisher>Japan: Fukuoka Medical Association</publisher><subject>Aged ; Aged, 80 and over ; Anesthesia, General ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - adverse effects ; Dose-Response Relationship, Drug ; Female ; Humans ; Hydrocortisone - administration & dosage ; Hydrocortisone - adverse effects ; Male ; Middle Aged ; Morbidity ; Postoperative Complications - classification ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Postoperative Complications - mortality ; Preoperative Care ; Severity of Illness Index ; Surgical Procedures, Operative ; Time Factors</subject><ispartof>FUKUOKA ACTA MEDICA, 2013-12, Vol.104 (12), p.499-506</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24693677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iguchi, Tomohiro</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><creatorcontrib>Inoue, Kentaro</creatorcontrib><creatorcontrib>Ito, Shuhei</creatorcontrib><creatorcontrib>Ohga, Takefumi</creatorcontrib><creatorcontrib>Nozoe, Tadahiro</creatorcontrib><creatorcontrib>Ezaki, Takahiro</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Uchiyama, Hideaki</creatorcontrib><creatorcontrib>Soejima, Yuji</creatorcontrib><creatorcontrib>Ikegami, Toru</creatorcontrib><creatorcontrib>Yamashita, Yo-Ichi</creatorcontrib><creatorcontrib>Kawanaka, Hirofumi</creatorcontrib><creatorcontrib>Ikeda, Tetsuo</creatorcontrib><creatorcontrib>Saeki, Hiroshi</creatorcontrib><creatorcontrib>Morita, Masaru</creatorcontrib><creatorcontrib>Maehara, Yoshihiko</creatorcontrib><creatorcontrib>Department of Surgery and Science</creatorcontrib><creatorcontrib>Fukuoka Higashi Medical Center</creatorcontrib><creatorcontrib>Department of Surgery</creatorcontrib><creatorcontrib>Kyushu University</creatorcontrib><creatorcontrib>Graduate School of Medical Sciences</creatorcontrib><title>Impact of High Preoperative Steroid Doses on Postoperative Complications among Patients on Prolonged Preoperative Steroid Therapy</title><title>FUKUOKA ACTA MEDICA</title><addtitle>Fukuoka Igaku Zasshi</addtitle><description>[Abstract] Corticosteroids are essential to maintain the organic homeostasis. Steroid, glucocorticoid or its synthetic analog is widely used for inflammatory and autoimmune diseases. Prolonged steroid therapy is reported to cause the susceptibility to infection, impaired wound healing and psychoneurosis, however whether the quantity of taking the preoperative steroid is associated the postoperative complication is still unknown. The aim of this study was to elucidate whether the steroid dose in patients on prolonged preoperative steroid therapy is associated postoperative morbidity and mortality. Twenty-five patients taking steroid for various illnesses and underwent the surgery under general anesthesia were selected in this study. The mean +- standard deviation and the median of the steroid dose converted into hydrocortisone (mg/day) were 39.2 +- 31.0 and 20, respectively. Of 25 cases, postoperative complications were seen in 10 cases. The postoperative complication was severe based on the grade of Clavien and Dindo by ANOVA as the doses of taking steroid increased (p=0.0171). The grave postoperative complication classified as Clavien and Dindo grade III occurred with 100% sensitivity and 87% specificity for the steroid dose converted into hydrocortisone > 80 mg/day. Preoperative taking the large amount of steroid (> 80mg/day) could cause a grave complication. More careful selection of the operative procedure might improve the mobidity rate.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia, General</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - adverse effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - administration & dosage</subject><subject>Hydrocortisone - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Postoperative Complications - classification</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - mortality</subject><subject>Preoperative Care</subject><subject>Severity of Illness Index</subject><subject>Surgical Procedures, Operative</subject><subject>Time Factors</subject><issn>0016-254X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE9Lw0AQxXNQbKn9CrJHL4Gd2c2_o1RthYIFK3hbNsmk3TbJxmwi9Og3d6EVL57mzXs_Bt5cBVPOIQ4xkh-TYO6cyTlHhAwhvQkmKONMxEkyDb5fmk4XA7MVW5ndnm16sh31ejBfxN4G6q0p2aN15Jht2ca64S9e2KarTeEX2zqmG9vu2MZv1A5nure196j8_-p2753udBtcV7p2NL_MWfD-_LRdrML16_Jl8bAOD5hGQwgayiIG38KXkJWuKg5JHgmOXiVYFJhyohIkCo8JianUxHVe5mmFQmoxC-7Pd7vefo7kBtUYV1Bd65bs6BREILiMMgEevbugY95QqbreNLo_qd-3eWB5BnzqH-Bb1qYldbBj3_oOqjxG1XgcrUIOQnHgElBx7qXMMsUjHiMKQIjFD0iygZk</recordid><startdate>20131225</startdate><enddate>20131225</enddate><creator>Iguchi, Tomohiro</creator><creator>Shirabe, Ken</creator><creator>Inoue, Kentaro</creator><creator>Ito, Shuhei</creator><creator>Ohga, Takefumi</creator><creator>Nozoe, Tadahiro</creator><creator>Ezaki, Takahiro</creator><creator>Yoshizumi, Tomoharu</creator><creator>Uchiyama, Hideaki</creator><creator>Soejima, Yuji</creator><creator>Ikegami, Toru</creator><creator>Yamashita, Yo-Ichi</creator><creator>Kawanaka, Hirofumi</creator><creator>Ikeda, Tetsuo</creator><creator>Saeki, Hiroshi</creator><creator>Morita, Masaru</creator><creator>Maehara, Yoshihiko</creator><general>Fukuoka Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20131225</creationdate><title>Impact of High Preoperative Steroid Doses on Postoperative Complications among Patients on Prolonged Preoperative Steroid Therapy</title><author>Iguchi, Tomohiro ; Shirabe, Ken ; Inoue, Kentaro ; Ito, Shuhei ; Ohga, Takefumi ; Nozoe, Tadahiro ; Ezaki, Takahiro ; Yoshizumi, Tomoharu ; Uchiyama, Hideaki ; Soejima, Yuji ; Ikegami, Toru ; Yamashita, Yo-Ichi ; Kawanaka, Hirofumi ; Ikeda, Tetsuo ; Saeki, Hiroshi ; Morita, Masaru ; Maehara, Yoshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j285t-1a1dc610021924faff017b5302ff072cc280eed1423c6134284ae0abdb8f234a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia, General</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - adverse effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - administration & dosage</topic><topic>Hydrocortisone - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Postoperative Complications - classification</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - mortality</topic><topic>Preoperative Care</topic><topic>Severity of Illness Index</topic><topic>Surgical Procedures, Operative</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iguchi, Tomohiro</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><creatorcontrib>Inoue, Kentaro</creatorcontrib><creatorcontrib>Ito, Shuhei</creatorcontrib><creatorcontrib>Ohga, Takefumi</creatorcontrib><creatorcontrib>Nozoe, Tadahiro</creatorcontrib><creatorcontrib>Ezaki, Takahiro</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Uchiyama, Hideaki</creatorcontrib><creatorcontrib>Soejima, Yuji</creatorcontrib><creatorcontrib>Ikegami, Toru</creatorcontrib><creatorcontrib>Yamashita, Yo-Ichi</creatorcontrib><creatorcontrib>Kawanaka, Hirofumi</creatorcontrib><creatorcontrib>Ikeda, Tetsuo</creatorcontrib><creatorcontrib>Saeki, Hiroshi</creatorcontrib><creatorcontrib>Morita, Masaru</creatorcontrib><creatorcontrib>Maehara, Yoshihiko</creatorcontrib><creatorcontrib>Department of Surgery and Science</creatorcontrib><creatorcontrib>Fukuoka Higashi Medical Center</creatorcontrib><creatorcontrib>Department of Surgery</creatorcontrib><creatorcontrib>Kyushu University</creatorcontrib><creatorcontrib>Graduate School of Medical Sciences</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>FUKUOKA ACTA MEDICA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iguchi, Tomohiro</au><au>Shirabe, Ken</au><au>Inoue, Kentaro</au><au>Ito, Shuhei</au><au>Ohga, Takefumi</au><au>Nozoe, Tadahiro</au><au>Ezaki, Takahiro</au><au>Yoshizumi, Tomoharu</au><au>Uchiyama, Hideaki</au><au>Soejima, Yuji</au><au>Ikegami, Toru</au><au>Yamashita, Yo-Ichi</au><au>Kawanaka, Hirofumi</au><au>Ikeda, Tetsuo</au><au>Saeki, Hiroshi</au><au>Morita, Masaru</au><au>Maehara, Yoshihiko</au><aucorp>Department of Surgery and Science</aucorp><aucorp>Fukuoka Higashi Medical Center</aucorp><aucorp>Department of Surgery</aucorp><aucorp>Kyushu University</aucorp><aucorp>Graduate School of Medical Sciences</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of High Preoperative Steroid Doses on Postoperative Complications among Patients on Prolonged Preoperative Steroid Therapy</atitle><jtitle>FUKUOKA ACTA MEDICA</jtitle><addtitle>Fukuoka Igaku Zasshi</addtitle><date>2013-12-25</date><risdate>2013</risdate><volume>104</volume><issue>12</issue><spage>499</spage><epage>506</epage><pages>499-506</pages><issn>0016-254X</issn><abstract>[Abstract] Corticosteroids are essential to maintain the organic homeostasis. Steroid, glucocorticoid or its synthetic analog is widely used for inflammatory and autoimmune diseases. Prolonged steroid therapy is reported to cause the susceptibility to infection, impaired wound healing and psychoneurosis, however whether the quantity of taking the preoperative steroid is associated the postoperative complication is still unknown. The aim of this study was to elucidate whether the steroid dose in patients on prolonged preoperative steroid therapy is associated postoperative morbidity and mortality. Twenty-five patients taking steroid for various illnesses and underwent the surgery under general anesthesia were selected in this study. The mean +- standard deviation and the median of the steroid dose converted into hydrocortisone (mg/day) were 39.2 +- 31.0 and 20, respectively. Of 25 cases, postoperative complications were seen in 10 cases. The postoperative complication was severe based on the grade of Clavien and Dindo by ANOVA as the doses of taking steroid increased (p=0.0171). The grave postoperative complication classified as Clavien and Dindo grade III occurred with 100% sensitivity and 87% specificity for the steroid dose converted into hydrocortisone > 80 mg/day. Preoperative taking the large amount of steroid (> 80mg/day) could cause a grave complication. More careful selection of the operative procedure might improve the mobidity rate.</abstract><cop>Japan</cop><pub>Fukuoka Medical Association</pub><pmid>24693677</pmid><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-254X |
| ispartof | FUKUOKA ACTA MEDICA, 2013-12, Vol.104 (12), p.499-506 |
| issn | 0016-254X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1513045931 |
| source | MEDLINE; Freely Accessible Japanese Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Aged, 80 and over Anesthesia, General Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - adverse effects Dose-Response Relationship, Drug Female Humans Hydrocortisone - administration & dosage Hydrocortisone - adverse effects Male Middle Aged Morbidity Postoperative Complications - classification Postoperative Complications - epidemiology Postoperative Complications - etiology Postoperative Complications - mortality Preoperative Care Severity of Illness Index Surgical Procedures, Operative Time Factors |
| title | Impact of High Preoperative Steroid Doses on Postoperative Complications among Patients on Prolonged Preoperative Steroid Therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T12%3A22%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20High%20Preoperative%20Steroid%20Doses%20on%20Postoperative%20Complications%20among%20Patients%20on%20Prolonged%20Preoperative%20Steroid%20Therapy&rft.jtitle=FUKUOKA%20ACTA%20MEDICA&rft.au=Iguchi,%20Tomohiro&rft.aucorp=Department%20of%20Surgery%20and%20Science&rft.date=2013-12-25&rft.volume=104&rft.issue=12&rft.spage=499&rft.epage=506&rft.pages=499-506&rft.issn=0016-254X&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1513045931%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1513045931&rft_id=info:pmid/24693677&rfr_iscdi=true |