Optimum Hepatic Parenchymal Dissection to Prevent Bile Leak: A Comparative Study Using Electrosurgical and Stapling Devices in Swine
[Abstract] [Background] Bile leakage is a serious complication of liver resection, and its treatment is very time-consuming. In open liver resection, Glisson's sheaths are usually disconnected by ligation to the extent possible during the parenchyma dissection. However, in laparoscopic surgery,...
Gespeichert in:
| Veröffentlicht in: | FUKUOKA ACTA MEDICA 2013-12, Vol.104 (12), p.507-514 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng ; jpn |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 514 |
|---|---|
| container_issue | 12 |
| container_start_page | 507 |
| container_title | FUKUOKA ACTA MEDICA |
| container_volume | 104 |
| creator | Ikeda, Tetsuo Akahoshi, Tomohiko Kawanaka, Hirofumi Uchiyama, Hideaki Yamashita, Yo-ichi Morita, Masaru Oki, Eiji Saeki, Hiroshi Sugimachi, Keishi Ikegami, Toru Yoshizumi, Tomoharu Soejima, Yuji Shirabe, Ken Mimori, Koshi Watanabe, Masayuki Hashizume, Makoto Maehara, Yoshihiko |
| description | [Abstract] [Background] Bile leakage is a serious complication of liver resection, and its treatment is very time-consuming. In open liver resection, Glisson's sheaths are usually disconnected by ligation to the extent possible during the parenchyma dissection. However, in laparoscopic surgery, the ligation, suture, and hemostasis are more difficult than in open surgery. For this reason, in laparoscopic liver resection, liver parenchyma dissection is generally accomplished using electrosurgical or stapling devices. [Purpose] The purpose of this study was to verify the authenticity of electrosurgical devices attached an automatic irrigation function (AI) and stapling devices for laparoscopic liver parenchymal dissection. [Methods] Four devices were used for liver parenchymal dissection in laparoscopic hepatic wedge resection, in pigs: monopolar high-frequency electric cautery attached AI (MCI) (n=6), bipolar high-frequency electric cautery attached AI (BCI) (n=6), bipolar tissue sealing system (LigaSureTM) attached AI (BSI) and an endoscopic stapling device (ECHELON FLEXTM ENDOPATH(R)) (ES). In each group, burst pressures were tested using an electronic manometer, paying special attention to the location(s) of the first disruption(s). The dissected tissues were examined histologically. [Results] Pressures used in electrosurgical devices attach AI were significantly higher compared to pressures used in a ES (P |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1513045698</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1513045698</sourcerecordid><originalsourceid>FETCH-LOGICAL-j285t-3365b5ebca5f30c646e6ca58bfe737723c311110277ccec93b5b256bf2aa2fe43</originalsourceid><addsrcrecordid>eNo1kE9LAzEQxfegaKl-BcnRSyF_Ntmtt9rWVigoqOAtZLOzmnY3WZNNpXc_uCnVOcwMvN88eHOWjTAmYkJ5_n6ZXYdgKowpJVNKyovskuZiykRRjrKfp34wXezQGno1GI2elQerPw-datHChAB6MM6iwaFnD3uwA7o3LaANqN0dmqG563rl0-Ue0MsQ6wN6C8Z-oGWbDr0L0X8YnayUrZOu-vYoLmBvNARkLHr5NhausvNGtQGu_-Y4e3tYvs7Xk83T6nE-20y2tOTDhDHBKw6VVrxhWItcgEh7WTVQsKKgTDOSCtOi0Br0lFW8olxUDVWKNpCzcXZ78u29-4oQBtmZoKFtlQUXgyScMJxzMS0TevOHxqqDWvbedMof5P_nErA6AUk9JnQ2RQO5ddHblEHWO97EXXSSYsIkJjgnVGKcS8xxkRrJKWWEkoL9AgFkgfE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1513045698</pqid></control><display><type>article</type><title>Optimum Hepatic Parenchymal Dissection to Prevent Bile Leak: A Comparative Study Using Electrosurgical and Stapling Devices in Swine</title><source>MEDLINE</source><source>Freely Accessible Japanese Titles</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Ikeda, Tetsuo ; Akahoshi, Tomohiko ; Kawanaka, Hirofumi ; Uchiyama, Hideaki ; Yamashita, Yo-ichi ; Morita, Masaru ; Oki, Eiji ; Saeki, Hiroshi ; Sugimachi, Keishi ; Ikegami, Toru ; Yoshizumi, Tomoharu ; Soejima, Yuji ; Shirabe, Ken ; Mimori, Koshi ; Watanabe, Masayuki ; Hashizume, Makoto ; Maehara, Yoshihiko</creator><creatorcontrib>Ikeda, Tetsuo ; Akahoshi, Tomohiko ; Kawanaka, Hirofumi ; Uchiyama, Hideaki ; Yamashita, Yo-ichi ; Morita, Masaru ; Oki, Eiji ; Saeki, Hiroshi ; Sugimachi, Keishi ; Ikegami, Toru ; Yoshizumi, Tomoharu ; Soejima, Yuji ; Shirabe, Ken ; Mimori, Koshi ; Watanabe, Masayuki ; Hashizume, Makoto ; Maehara, Yoshihiko ; Kyushu University ; Kumamoto University ; Kyushu University Beppu Hospital ; Department of Surgery and Science ; Department of Surgery ; Department of Gastroenterological Surgery ; Center for Integration of Advanced Medicine ; Graduate School of Medical Sciences</creatorcontrib><description>[Abstract] [Background] Bile leakage is a serious complication of liver resection, and its treatment is very time-consuming. In open liver resection, Glisson's sheaths are usually disconnected by ligation to the extent possible during the parenchyma dissection. However, in laparoscopic surgery, the ligation, suture, and hemostasis are more difficult than in open surgery. For this reason, in laparoscopic liver resection, liver parenchyma dissection is generally accomplished using electrosurgical or stapling devices. [Purpose] The purpose of this study was to verify the authenticity of electrosurgical devices attached an automatic irrigation function (AI) and stapling devices for laparoscopic liver parenchymal dissection. [Methods] Four devices were used for liver parenchymal dissection in laparoscopic hepatic wedge resection, in pigs: monopolar high-frequency electric cautery attached AI (MCI) (n=6), bipolar high-frequency electric cautery attached AI (BCI) (n=6), bipolar tissue sealing system (LigaSureTM) attached AI (BSI) and an endoscopic stapling device (ECHELON FLEXTM ENDOPATH(R)) (ES). In each group, burst pressures were tested using an electronic manometer, paying special attention to the location(s) of the first disruption(s). The dissected tissues were examined histologically. [Results] Pressures used in electrosurgical devices attach AI were significantly higher compared to pressures used in a ES (P<0.001). While thermal denaturation of the liver parenchyma occurred at approximately 2-3 mm of depth when bipolar high-frequency electric cautery was used for dissection, it reached up to more than 10 mm with monopolar high-frequency electric cautery. All of the first disruption points of stapling were at stapling line. [Conclusions] Electrosurgical devices with an automatic irrigation function are useful devices to dissect the liver parenchyma.</description><identifier>ISSN: 0016-254X</identifier><identifier>PMID: 24693678</identifier><language>eng ; jpn</language><publisher>Japan: Fukuoka Medical Association</publisher><subject>Anastomotic Leak - prevention & control ; Animals ; Bile ; Bile Ducts - injuries ; Electrosurgery - adverse effects ; Electrosurgery - instrumentation ; Female ; Hepatectomy - adverse effects ; Hepatectomy - instrumentation ; Intraoperative Complications - etiology ; Laparoscopy - adverse effects ; Laparoscopy - instrumentation ; Liver - surgery ; Surgical Stapling - adverse effects ; Surgical Stapling - instrumentation ; Swine</subject><ispartof>FUKUOKA ACTA MEDICA, 2013-12, Vol.104 (12), p.507-514</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24693678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikeda, Tetsuo</creatorcontrib><creatorcontrib>Akahoshi, Tomohiko</creatorcontrib><creatorcontrib>Kawanaka, Hirofumi</creatorcontrib><creatorcontrib>Uchiyama, Hideaki</creatorcontrib><creatorcontrib>Yamashita, Yo-ichi</creatorcontrib><creatorcontrib>Morita, Masaru</creatorcontrib><creatorcontrib>Oki, Eiji</creatorcontrib><creatorcontrib>Saeki, Hiroshi</creatorcontrib><creatorcontrib>Sugimachi, Keishi</creatorcontrib><creatorcontrib>Ikegami, Toru</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Soejima, Yuji</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><creatorcontrib>Mimori, Koshi</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><creatorcontrib>Hashizume, Makoto</creatorcontrib><creatorcontrib>Maehara, Yoshihiko</creatorcontrib><creatorcontrib>Kyushu University</creatorcontrib><creatorcontrib>Kumamoto University</creatorcontrib><creatorcontrib>Kyushu University Beppu Hospital</creatorcontrib><creatorcontrib>Department of Surgery and Science</creatorcontrib><creatorcontrib>Department of Surgery</creatorcontrib><creatorcontrib>Department of Gastroenterological Surgery</creatorcontrib><creatorcontrib>Center for Integration of Advanced Medicine</creatorcontrib><creatorcontrib>Graduate School of Medical Sciences</creatorcontrib><title>Optimum Hepatic Parenchymal Dissection to Prevent Bile Leak: A Comparative Study Using Electrosurgical and Stapling Devices in Swine</title><title>FUKUOKA ACTA MEDICA</title><addtitle>Fukuoka Igaku Zasshi</addtitle><description>[Abstract] [Background] Bile leakage is a serious complication of liver resection, and its treatment is very time-consuming. In open liver resection, Glisson's sheaths are usually disconnected by ligation to the extent possible during the parenchyma dissection. However, in laparoscopic surgery, the ligation, suture, and hemostasis are more difficult than in open surgery. For this reason, in laparoscopic liver resection, liver parenchyma dissection is generally accomplished using electrosurgical or stapling devices. [Purpose] The purpose of this study was to verify the authenticity of electrosurgical devices attached an automatic irrigation function (AI) and stapling devices for laparoscopic liver parenchymal dissection. [Methods] Four devices were used for liver parenchymal dissection in laparoscopic hepatic wedge resection, in pigs: monopolar high-frequency electric cautery attached AI (MCI) (n=6), bipolar high-frequency electric cautery attached AI (BCI) (n=6), bipolar tissue sealing system (LigaSureTM) attached AI (BSI) and an endoscopic stapling device (ECHELON FLEXTM ENDOPATH(R)) (ES). In each group, burst pressures were tested using an electronic manometer, paying special attention to the location(s) of the first disruption(s). The dissected tissues were examined histologically. [Results] Pressures used in electrosurgical devices attach AI were significantly higher compared to pressures used in a ES (P<0.001). While thermal denaturation of the liver parenchyma occurred at approximately 2-3 mm of depth when bipolar high-frequency electric cautery was used for dissection, it reached up to more than 10 mm with monopolar high-frequency electric cautery. All of the first disruption points of stapling were at stapling line. [Conclusions] Electrosurgical devices with an automatic irrigation function are useful devices to dissect the liver parenchyma.</description><subject>Anastomotic Leak - prevention & control</subject><subject>Animals</subject><subject>Bile</subject><subject>Bile Ducts - injuries</subject><subject>Electrosurgery - adverse effects</subject><subject>Electrosurgery - instrumentation</subject><subject>Female</subject><subject>Hepatectomy - adverse effects</subject><subject>Hepatectomy - instrumentation</subject><subject>Intraoperative Complications - etiology</subject><subject>Laparoscopy - adverse effects</subject><subject>Laparoscopy - instrumentation</subject><subject>Liver - surgery</subject><subject>Surgical Stapling - adverse effects</subject><subject>Surgical Stapling - instrumentation</subject><subject>Swine</subject><issn>0016-254X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE9LAzEQxfegaKl-BcnRSyF_Ntmtt9rWVigoqOAtZLOzmnY3WZNNpXc_uCnVOcwMvN88eHOWjTAmYkJ5_n6ZXYdgKowpJVNKyovskuZiykRRjrKfp34wXezQGno1GI2elQerPw-datHChAB6MM6iwaFnD3uwA7o3LaANqN0dmqG563rl0-Ue0MsQ6wN6C8Z-oGWbDr0L0X8YnayUrZOu-vYoLmBvNARkLHr5NhausvNGtQGu_-Y4e3tYvs7Xk83T6nE-20y2tOTDhDHBKw6VVrxhWItcgEh7WTVQsKKgTDOSCtOi0Br0lFW8olxUDVWKNpCzcXZ78u29-4oQBtmZoKFtlQUXgyScMJxzMS0TevOHxqqDWvbedMof5P_nErA6AUk9JnQ2RQO5ddHblEHWO97EXXSSYsIkJjgnVGKcS8xxkRrJKWWEkoL9AgFkgfE</recordid><startdate>20131225</startdate><enddate>20131225</enddate><creator>Ikeda, Tetsuo</creator><creator>Akahoshi, Tomohiko</creator><creator>Kawanaka, Hirofumi</creator><creator>Uchiyama, Hideaki</creator><creator>Yamashita, Yo-ichi</creator><creator>Morita, Masaru</creator><creator>Oki, Eiji</creator><creator>Saeki, Hiroshi</creator><creator>Sugimachi, Keishi</creator><creator>Ikegami, Toru</creator><creator>Yoshizumi, Tomoharu</creator><creator>Soejima, Yuji</creator><creator>Shirabe, Ken</creator><creator>Mimori, Koshi</creator><creator>Watanabe, Masayuki</creator><creator>Hashizume, Makoto</creator><creator>Maehara, Yoshihiko</creator><general>Fukuoka Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20131225</creationdate><title>Optimum Hepatic Parenchymal Dissection to Prevent Bile Leak: A Comparative Study Using Electrosurgical and Stapling Devices in Swine</title><author>Ikeda, Tetsuo ; Akahoshi, Tomohiko ; Kawanaka, Hirofumi ; Uchiyama, Hideaki ; Yamashita, Yo-ichi ; Morita, Masaru ; Oki, Eiji ; Saeki, Hiroshi ; Sugimachi, Keishi ; Ikegami, Toru ; Yoshizumi, Tomoharu ; Soejima, Yuji ; Shirabe, Ken ; Mimori, Koshi ; Watanabe, Masayuki ; Hashizume, Makoto ; Maehara, Yoshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j285t-3365b5ebca5f30c646e6ca58bfe737723c311110277ccec93b5b256bf2aa2fe43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2013</creationdate><topic>Anastomotic Leak - prevention & control</topic><topic>Animals</topic><topic>Bile</topic><topic>Bile Ducts - injuries</topic><topic>Electrosurgery - adverse effects</topic><topic>Electrosurgery - instrumentation</topic><topic>Female</topic><topic>Hepatectomy - adverse effects</topic><topic>Hepatectomy - instrumentation</topic><topic>Intraoperative Complications - etiology</topic><topic>Laparoscopy - adverse effects</topic><topic>Laparoscopy - instrumentation</topic><topic>Liver - surgery</topic><topic>Surgical Stapling - adverse effects</topic><topic>Surgical Stapling - instrumentation</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikeda, Tetsuo</creatorcontrib><creatorcontrib>Akahoshi, Tomohiko</creatorcontrib><creatorcontrib>Kawanaka, Hirofumi</creatorcontrib><creatorcontrib>Uchiyama, Hideaki</creatorcontrib><creatorcontrib>Yamashita, Yo-ichi</creatorcontrib><creatorcontrib>Morita, Masaru</creatorcontrib><creatorcontrib>Oki, Eiji</creatorcontrib><creatorcontrib>Saeki, Hiroshi</creatorcontrib><creatorcontrib>Sugimachi, Keishi</creatorcontrib><creatorcontrib>Ikegami, Toru</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Soejima, Yuji</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><creatorcontrib>Mimori, Koshi</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><creatorcontrib>Hashizume, Makoto</creatorcontrib><creatorcontrib>Maehara, Yoshihiko</creatorcontrib><creatorcontrib>Kyushu University</creatorcontrib><creatorcontrib>Kumamoto University</creatorcontrib><creatorcontrib>Kyushu University Beppu Hospital</creatorcontrib><creatorcontrib>Department of Surgery and Science</creatorcontrib><creatorcontrib>Department of Surgery</creatorcontrib><creatorcontrib>Department of Gastroenterological Surgery</creatorcontrib><creatorcontrib>Center for Integration of Advanced Medicine</creatorcontrib><creatorcontrib>Graduate School of Medical Sciences</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>FUKUOKA ACTA MEDICA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikeda, Tetsuo</au><au>Akahoshi, Tomohiko</au><au>Kawanaka, Hirofumi</au><au>Uchiyama, Hideaki</au><au>Yamashita, Yo-ichi</au><au>Morita, Masaru</au><au>Oki, Eiji</au><au>Saeki, Hiroshi</au><au>Sugimachi, Keishi</au><au>Ikegami, Toru</au><au>Yoshizumi, Tomoharu</au><au>Soejima, Yuji</au><au>Shirabe, Ken</au><au>Mimori, Koshi</au><au>Watanabe, Masayuki</au><au>Hashizume, Makoto</au><au>Maehara, Yoshihiko</au><aucorp>Kyushu University</aucorp><aucorp>Kumamoto University</aucorp><aucorp>Kyushu University Beppu Hospital</aucorp><aucorp>Department of Surgery and Science</aucorp><aucorp>Department of Surgery</aucorp><aucorp>Department of Gastroenterological Surgery</aucorp><aucorp>Center for Integration of Advanced Medicine</aucorp><aucorp>Graduate School of Medical Sciences</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimum Hepatic Parenchymal Dissection to Prevent Bile Leak: A Comparative Study Using Electrosurgical and Stapling Devices in Swine</atitle><jtitle>FUKUOKA ACTA MEDICA</jtitle><addtitle>Fukuoka Igaku Zasshi</addtitle><date>2013-12-25</date><risdate>2013</risdate><volume>104</volume><issue>12</issue><spage>507</spage><epage>514</epage><pages>507-514</pages><issn>0016-254X</issn><abstract>[Abstract] [Background] Bile leakage is a serious complication of liver resection, and its treatment is very time-consuming. In open liver resection, Glisson's sheaths are usually disconnected by ligation to the extent possible during the parenchyma dissection. However, in laparoscopic surgery, the ligation, suture, and hemostasis are more difficult than in open surgery. For this reason, in laparoscopic liver resection, liver parenchyma dissection is generally accomplished using electrosurgical or stapling devices. [Purpose] The purpose of this study was to verify the authenticity of electrosurgical devices attached an automatic irrigation function (AI) and stapling devices for laparoscopic liver parenchymal dissection. [Methods] Four devices were used for liver parenchymal dissection in laparoscopic hepatic wedge resection, in pigs: monopolar high-frequency electric cautery attached AI (MCI) (n=6), bipolar high-frequency electric cautery attached AI (BCI) (n=6), bipolar tissue sealing system (LigaSureTM) attached AI (BSI) and an endoscopic stapling device (ECHELON FLEXTM ENDOPATH(R)) (ES). In each group, burst pressures were tested using an electronic manometer, paying special attention to the location(s) of the first disruption(s). The dissected tissues were examined histologically. [Results] Pressures used in electrosurgical devices attach AI were significantly higher compared to pressures used in a ES (P<0.001). While thermal denaturation of the liver parenchyma occurred at approximately 2-3 mm of depth when bipolar high-frequency electric cautery was used for dissection, it reached up to more than 10 mm with monopolar high-frequency electric cautery. All of the first disruption points of stapling were at stapling line. [Conclusions] Electrosurgical devices with an automatic irrigation function are useful devices to dissect the liver parenchyma.</abstract><cop>Japan</cop><pub>Fukuoka Medical Association</pub><pmid>24693678</pmid><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-254X |
| ispartof | FUKUOKA ACTA MEDICA, 2013-12, Vol.104 (12), p.507-514 |
| issn | 0016-254X |
| language | eng ; jpn |
| recordid | cdi_proquest_miscellaneous_1513045698 |
| source | MEDLINE; Freely Accessible Japanese Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anastomotic Leak - prevention & control Animals Bile Bile Ducts - injuries Electrosurgery - adverse effects Electrosurgery - instrumentation Female Hepatectomy - adverse effects Hepatectomy - instrumentation Intraoperative Complications - etiology Laparoscopy - adverse effects Laparoscopy - instrumentation Liver - surgery Surgical Stapling - adverse effects Surgical Stapling - instrumentation Swine |
| title | Optimum Hepatic Parenchymal Dissection to Prevent Bile Leak: A Comparative Study Using Electrosurgical and Stapling Devices in Swine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T12%3A01%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Optimum%20Hepatic%20Parenchymal%20Dissection%20to%20Prevent%20Bile%20Leak:%20A%20Comparative%20Study%20Using%20Electrosurgical%20and%20Stapling%20Devices%20in%20Swine&rft.jtitle=FUKUOKA%20ACTA%20MEDICA&rft.au=Ikeda,%20Tetsuo&rft.aucorp=Kyushu%20University&rft.date=2013-12-25&rft.volume=104&rft.issue=12&rft.spage=507&rft.epage=514&rft.pages=507-514&rft.issn=0016-254X&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1513045698%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1513045698&rft_id=info:pmid/24693678&rfr_iscdi=true |