No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication
D. R. Franz, R. D. Leclaire, W. B. Lawrence and D. L. Bunner. No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication. Toxicon 26, 1098–1101, 1988—Because reactive oxygen species are formed during the metabolism of several toxins that cause similar pathologic chan...
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| Veröffentlicht in: | Toxicon (Oxford) 1988, Vol.26 (11), p.1098-1101 |
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| container_issue | 11 |
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| container_title | Toxicon (Oxford) |
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| creator | Franz, David R. Leclaire, Ross D. Lawrence, Wade B. Bunner, David L. |
| description | D. R. Franz,
R. D. Leclaire,
W. B. Lawrence and
D. L. Bunner. No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication.
Toxicon
26, 1098–1101, 1988—Because reactive oxygen species are formed during the metabolism of several toxins that cause similar pathologic changes, we hypothesized that compounds that alter the concentration of reactive oxygen species would alter the toxic effects of the peptide-hepatotoxin produced principally by
Microcystis aeruginosa. Pretreatment with alloxan, butylated hydroxyanisole or desferrioxamine did not alter the severity of microcystin-LR intoxication in fed mice. Furthermore, fasting mice for 24 hr before testing, which unmasks lipid peroxidation in paracetamol intoxication, did not alter the effect of butylated hydroxyanisole pretreatment. |
| doi_str_mv | 10.1016/0041-0101(88)90210-3 |
| format | Article |
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R. D. Leclaire,
W. B. Lawrence and
D. L. Bunner. No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication.
Toxicon
26, 1098–1101, 1988—Because reactive oxygen species are formed during the metabolism of several toxins that cause similar pathologic changes, we hypothesized that compounds that alter the concentration of reactive oxygen species would alter the toxic effects of the peptide-hepatotoxin produced principally by
Microcystis aeruginosa. Pretreatment with alloxan, butylated hydroxyanisole or desferrioxamine did not alter the severity of microcystin-LR intoxication in fed mice. Furthermore, fasting mice for 24 hr before testing, which unmasks lipid peroxidation in paracetamol intoxication, did not alter the effect of butylated hydroxyanisole pretreatment.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/0041-0101(88)90210-3</identifier><identifier>PMID: 3245055</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Alloxan - pharmacology ; Animals ; Biological and medical sciences ; Butylated Hydroxyanisole - pharmacology ; Deferoxamine - pharmacology ; Free Radicals ; Freshwater ; Lethal Dose 50 ; Liver - drug effects ; Liver - metabolism ; Male ; Medical sciences ; Mice ; Microcystins ; Microcystis aeruginosa ; Organ Size ; Oxygen - metabolism ; Peptides, Cyclic - toxicity ; Plant poisons toxicology ; Toxicology</subject><ispartof>Toxicon (Oxford), 1988, Vol.26 (11), p.1098-1101</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-25c1bb88c8ae2775d581bd1ac0a9d5f6ba0ceb54e2c3f4299a6f64c1bb83c7ef3</citedby><cites>FETCH-LOGICAL-c417t-25c1bb88c8ae2775d581bd1ac0a9d5f6ba0ceb54e2c3f4299a6f64c1bb83c7ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0041010188902103$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7271632$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3245055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franz, David R.</creatorcontrib><creatorcontrib>Leclaire, Ross D.</creatorcontrib><creatorcontrib>Lawrence, Wade B.</creatorcontrib><creatorcontrib>Bunner, David L.</creatorcontrib><title>No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>D. R. Franz,
R. D. Leclaire,
W. B. Lawrence and
D. L. Bunner. No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication.
Toxicon
26, 1098–1101, 1988—Because reactive oxygen species are formed during the metabolism of several toxins that cause similar pathologic changes, we hypothesized that compounds that alter the concentration of reactive oxygen species would alter the toxic effects of the peptide-hepatotoxin produced principally by
Microcystis aeruginosa. Pretreatment with alloxan, butylated hydroxyanisole or desferrioxamine did not alter the severity of microcystin-LR intoxication in fed mice. Furthermore, fasting mice for 24 hr before testing, which unmasks lipid peroxidation in paracetamol intoxication, did not alter the effect of butylated hydroxyanisole pretreatment.</description><subject>Alloxan - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Butylated Hydroxyanisole - pharmacology</subject><subject>Deferoxamine - pharmacology</subject><subject>Free Radicals</subject><subject>Freshwater</subject><subject>Lethal Dose 50</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microcystins</subject><subject>Microcystis aeruginosa</subject><subject>Organ Size</subject><subject>Oxygen - metabolism</subject><subject>Peptides, Cyclic - toxicity</subject><subject>Plant poisons toxicology</subject><subject>Toxicology</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSbdp_kEKPpTSHpzqw7LlS6CEtiksCYTmlIOQx6NExZa2khyy_752dtljTjPDPO8wPIScMXrOKKu_UVqxks7tF6W-tpQzWoojsmKqaUvBJH1DVgfkHXmf0l9KqVBtfUyOBa8klXJF7q9DgdYi5CLYYgz9NJgcYlqmiAaye8IiPG8f0JfO9xNgX2xMfgxDeNgWwRejgxhgm7Lz5fq2cD6HZwcmu-A_kLfWDAlP9_WE3P388efyqlzf_Pp9-X1dQsWaXHIJrOuUAmWQN43spWJdzwxQ0_bS1p2hgJ2skIOwFW9bU9u6eskIaNCKE_J5d3cTw78JU9ajS4DDYDyGKWkmGW-4EDNY7cD55ZQiWr2JbjRxqxnVi1O9CNOLMK2UfnGql9jH_f2pG7E_hPYS5_2n_d4kMIONxoNLB6zhDasFn7GLHYaziyeHUSdw6GejLs7-dR_c63_8B-jVk-c</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Franz, David R.</creator><creator>Leclaire, Ross D.</creator><creator>Lawrence, Wade B.</creator><creator>Bunner, David L.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>1988</creationdate><title>No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication</title><author>Franz, David R. ; Leclaire, Ross D. ; Lawrence, Wade B. ; Bunner, David L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-25c1bb88c8ae2775d581bd1ac0a9d5f6ba0ceb54e2c3f4299a6f64c1bb83c7ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Alloxan - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Butylated Hydroxyanisole - pharmacology</topic><topic>Deferoxamine - pharmacology</topic><topic>Free Radicals</topic><topic>Freshwater</topic><topic>Lethal Dose 50</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microcystins</topic><topic>Microcystis aeruginosa</topic><topic>Organ Size</topic><topic>Oxygen - metabolism</topic><topic>Peptides, Cyclic - toxicity</topic><topic>Plant poisons toxicology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franz, David R.</creatorcontrib><creatorcontrib>Leclaire, Ross D.</creatorcontrib><creatorcontrib>Lawrence, Wade B.</creatorcontrib><creatorcontrib>Bunner, David L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franz, David R.</au><au>Leclaire, Ross D.</au><au>Lawrence, Wade B.</au><au>Bunner, David L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1988</date><risdate>1988</risdate><volume>26</volume><issue>11</issue><spage>1098</spage><epage>1101</epage><pages>1098-1101</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>D. R. Franz,
R. D. Leclaire,
W. B. Lawrence and
D. L. Bunner. No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication.
Toxicon
26, 1098–1101, 1988—Because reactive oxygen species are formed during the metabolism of several toxins that cause similar pathologic changes, we hypothesized that compounds that alter the concentration of reactive oxygen species would alter the toxic effects of the peptide-hepatotoxin produced principally by
Microcystis aeruginosa. Pretreatment with alloxan, butylated hydroxyanisole or desferrioxamine did not alter the severity of microcystin-LR intoxication in fed mice. Furthermore, fasting mice for 24 hr before testing, which unmasks lipid peroxidation in paracetamol intoxication, did not alter the effect of butylated hydroxyanisole pretreatment.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3245055</pmid><doi>10.1016/0041-0101(88)90210-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Toxicon (Oxford), 1988, Vol.26 (11), p.1098-1101 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alloxan - pharmacology Animals Biological and medical sciences Butylated Hydroxyanisole - pharmacology Deferoxamine - pharmacology Free Radicals Freshwater Lethal Dose 50 Liver - drug effects Liver - metabolism Male Medical sciences Mice Microcystins Microcystis aeruginosa Organ Size Oxygen - metabolism Peptides, Cyclic - toxicity Plant poisons toxicology Toxicology |
| title | No effect of modulators of reactive oxygen-induced pathology on microcystin-LR intoxication |
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