Sigma-2 Receptor Ligands and Their Perspectives in Cancer Diagnosis and Therapy

The sigma‐2 receptor is highly expressed in various rapidly proliferating cancer cells and regarded as a cancer cell biomarker. Selective sigma‐2 ligands have been shown to specifically label the tumor sites, induce cancer cells to undergo apoptosis, and inhibit tumor growth. Sigma‐2 ligands are pot...

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Veröffentlicht in:	Medicinal research reviews 2014-05, Vol.34 (3), p.532-566
Hauptverfasser:	Huang, Yun-Sheng, Lu, He-Lin, Zhang, Lang-Jun, Wu, Zongwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticancer binding profile biomarker Cancer diagnostics Humans imaging Ligands Medical research Neoplasms - diagnosis Neoplasms - metabolism Neoplasms - therapy pharmacophore Protein Binding Receptors, sigma - metabolism sigma ligands sigma receptor Signal Transduction signaling
Online-Zugang:	Volltext
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