Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study
Summary Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization ana...
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| Veröffentlicht in: | Osteoporosis international 2014-04, Vol.25 (4), p.1247-1254 |
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| creator | Oei, L. Campos-Obando, N. Dehghan, A. Oei, E. H. G. Stolk, L. van Meurs, J. B. J. Hofman, A. Uitterlinden, A. G. Franco, O. H. Zillikens, M. C. Rivadeneira, F. |
| description | Summary
Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal.
Introduction
Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort.
Methods
At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years).
Results
CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 cm
3
; −0.020 to −0.003 cm
3
) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (
p
= 9 × 10
−56
), but not with fracture risk (HR = 1.00; 0.99–1.00;
p
= 0.23).
Conclusions
Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk. |
| doi_str_mv | 10.1007/s00198-013-2578-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1512336562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3246832761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-2fecbb5ea8116dc773cb8aec634245d3411908f72dbf71a19fb3a6bac089a6563</originalsourceid><addsrcrecordid>eNqNkUuLFDEUhYMoTjv6A9xIwI2b0jwqScWd9PiCAcEHuAup1K3ujF2pNjc10ht_u2l7FBEEVzc39zvnJhxCHnL2lDNmniFj3HYN47IRytTDLbLirayd1eo2WTErTWNb_vmM3EO8YlVjrblLzkSFjNZ8Rb5fREQIJaYNLVugGXa-xDnhNu5pD-UbQKLbuNk2CAljidexHChCXia6bjL4Kr0Gus9zgZioTwONKdR7hIGOuY6XXF0jfnn-0__9XArkwU_0Q1mGw31yZ_Q7hAc39Zx8evXy4_pNc_nu9dv1i8smtEyVRowQ-l6B7zjXQzBGhr7zELRsRasG2XJuWTcaMfSj4Z7bsZde9z6wznqttDwnT06-9aFfF8DipogBdjufYF7QccWFlJUU_4GyrhWKKVnRx3-hV_OSU_3IkTJKt8x0leInKuQZMcPo9jlOPh8cZ-6Yozvl6GqO7pijY1Xz6MZ56ScYfit-BVcBcQKwjtIG8h-r_-n6Aw8Yqfk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1507564078</pqid></control><display><type>article</type><title>Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Oei, L. ; Campos-Obando, N. ; Dehghan, A. ; Oei, E. H. G. ; Stolk, L. ; van Meurs, J. B. J. ; Hofman, A. ; Uitterlinden, A. G. ; Franco, O. H. ; Zillikens, M. C. ; Rivadeneira, F.</creator><creatorcontrib>Oei, L. ; Campos-Obando, N. ; Dehghan, A. ; Oei, E. H. G. ; Stolk, L. ; van Meurs, J. B. J. ; Hofman, A. ; Uitterlinden, A. G. ; Franco, O. H. ; Zillikens, M. C. ; Rivadeneira, F.</creatorcontrib><description>Summary
Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal.
Introduction
Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort.
Methods
At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years).
Results
CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 cm
3
; −0.020 to −0.003 cm
3
) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (
p
= 9 × 10
−56
), but not with fracture risk (HR = 1.00; 0.99–1.00;
p
= 0.23).
Conclusions
Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-013-2578-0</identifier><identifier>PMID: 24337661</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Aged ; Biomarkers ; Biomarkers - blood ; Body Mass Index ; Bone Density - physiology ; Bone diseases ; Bones ; C-Reactive Protein - analysis ; C-Reactive Protein - genetics ; C-Reactive Protein - physiology ; Endocrinology ; Epidemiology ; Female ; Femur Neck - physiopathology ; Fractures ; Genotype ; Humans ; Incidence ; Lumbar Vertebrae - physiopathology ; Male ; Medicine ; Medicine & Public Health ; Mendelian Randomization Analysis ; Middle Aged ; Netherlands - epidemiology ; Original Article ; Orthopedics ; Osteoporotic Fractures - blood ; Osteoporotic Fractures - epidemiology ; Osteoporotic Fractures - genetics ; Osteoporotic Fractures - physiopathology ; Polymorphism, Single Nucleotide ; Prospective Studies ; Proteins ; Rheumatology ; Risk assessment ; Risk Assessment - methods</subject><ispartof>Osteoporosis international, 2014-04, Vol.25 (4), p.1247-1254</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2013</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-2fecbb5ea8116dc773cb8aec634245d3411908f72dbf71a19fb3a6bac089a6563</citedby><cites>FETCH-LOGICAL-c405t-2fecbb5ea8116dc773cb8aec634245d3411908f72dbf71a19fb3a6bac089a6563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-013-2578-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-013-2578-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24337661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oei, L.</creatorcontrib><creatorcontrib>Campos-Obando, N.</creatorcontrib><creatorcontrib>Dehghan, A.</creatorcontrib><creatorcontrib>Oei, E. H. G.</creatorcontrib><creatorcontrib>Stolk, L.</creatorcontrib><creatorcontrib>van Meurs, J. B. J.</creatorcontrib><creatorcontrib>Hofman, A.</creatorcontrib><creatorcontrib>Uitterlinden, A. G.</creatorcontrib><creatorcontrib>Franco, O. H.</creatorcontrib><creatorcontrib>Zillikens, M. C.</creatorcontrib><creatorcontrib>Rivadeneira, F.</creatorcontrib><title>Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal.
Introduction
Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort.
Methods
At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years).
Results
CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 cm
3
; −0.020 to −0.003 cm
3
) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (
p
= 9 × 10
−56
), but not with fracture risk (HR = 1.00; 0.99–1.00;
p
= 0.23).
Conclusions
Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk.</description><subject>Aged</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Bone Density - physiology</subject><subject>Bone diseases</subject><subject>Bones</subject><subject>C-Reactive Protein - analysis</subject><subject>C-Reactive Protein - genetics</subject><subject>C-Reactive Protein - physiology</subject><subject>Endocrinology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Femur Neck - physiopathology</subject><subject>Fractures</subject><subject>Genotype</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mendelian Randomization Analysis</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporotic Fractures - blood</subject><subject>Osteoporotic Fractures - epidemiology</subject><subject>Osteoporotic Fractures - genetics</subject><subject>Osteoporotic Fractures - physiopathology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Rheumatology</subject><subject>Risk assessment</subject><subject>Risk Assessment - methods</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkUuLFDEUhYMoTjv6A9xIwI2b0jwqScWd9PiCAcEHuAup1K3ujF2pNjc10ht_u2l7FBEEVzc39zvnJhxCHnL2lDNmniFj3HYN47IRytTDLbLirayd1eo2WTErTWNb_vmM3EO8YlVjrblLzkSFjNZ8Rb5fREQIJaYNLVugGXa-xDnhNu5pD-UbQKLbuNk2CAljidexHChCXia6bjL4Kr0Gus9zgZioTwONKdR7hIGOuY6XXF0jfnn-0__9XArkwU_0Q1mGw31yZ_Q7hAc39Zx8evXy4_pNc_nu9dv1i8smtEyVRowQ-l6B7zjXQzBGhr7zELRsRasG2XJuWTcaMfSj4Z7bsZde9z6wznqttDwnT06-9aFfF8DipogBdjufYF7QccWFlJUU_4GyrhWKKVnRx3-hV_OSU_3IkTJKt8x0leInKuQZMcPo9jlOPh8cZ-6Yozvl6GqO7pijY1Xz6MZ56ScYfit-BVcBcQKwjtIG8h-r_-n6Aw8Yqfk</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Oei, L.</creator><creator>Campos-Obando, N.</creator><creator>Dehghan, A.</creator><creator>Oei, E. H. G.</creator><creator>Stolk, L.</creator><creator>van Meurs, J. B. J.</creator><creator>Hofman, A.</creator><creator>Uitterlinden, A. G.</creator><creator>Franco, O. H.</creator><creator>Zillikens, M. C.</creator><creator>Rivadeneira, F.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study</title><author>Oei, L. ; Campos-Obando, N. ; Dehghan, A. ; Oei, E. H. G. ; Stolk, L. ; van Meurs, J. B. J. ; Hofman, A. ; Uitterlinden, A. G. ; Franco, O. H. ; Zillikens, M. C. ; Rivadeneira, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-2fecbb5ea8116dc773cb8aec634245d3411908f72dbf71a19fb3a6bac089a6563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Bone Density - physiology</topic><topic>Bone diseases</topic><topic>Bones</topic><topic>C-Reactive Protein - analysis</topic><topic>C-Reactive Protein - genetics</topic><topic>C-Reactive Protein - physiology</topic><topic>Endocrinology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Femur Neck - physiopathology</topic><topic>Fractures</topic><topic>Genotype</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lumbar Vertebrae - physiopathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mendelian Randomization Analysis</topic><topic>Middle Aged</topic><topic>Netherlands - epidemiology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporotic Fractures - blood</topic><topic>Osteoporotic Fractures - epidemiology</topic><topic>Osteoporotic Fractures - genetics</topic><topic>Osteoporotic Fractures - physiopathology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Rheumatology</topic><topic>Risk assessment</topic><topic>Risk Assessment - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oei, L.</creatorcontrib><creatorcontrib>Campos-Obando, N.</creatorcontrib><creatorcontrib>Dehghan, A.</creatorcontrib><creatorcontrib>Oei, E. H. G.</creatorcontrib><creatorcontrib>Stolk, L.</creatorcontrib><creatorcontrib>van Meurs, J. B. J.</creatorcontrib><creatorcontrib>Hofman, A.</creatorcontrib><creatorcontrib>Uitterlinden, A. G.</creatorcontrib><creatorcontrib>Franco, O. H.</creatorcontrib><creatorcontrib>Zillikens, M. C.</creatorcontrib><creatorcontrib>Rivadeneira, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oei, L.</au><au>Campos-Obando, N.</au><au>Dehghan, A.</au><au>Oei, E. H. G.</au><au>Stolk, L.</au><au>van Meurs, J. B. J.</au><au>Hofman, A.</au><au>Uitterlinden, A. G.</au><au>Franco, O. H.</au><au>Zillikens, M. C.</au><au>Rivadeneira, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>25</volume><issue>4</issue><spage>1247</spage><epage>1254</epage><pages>1247-1254</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
Serum high-sensitivity C-reactive protein (CRP) is an inflammatory biomarker. We investigated the relationship between CRP and bone health in the Rotterdam Study. Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal.
Introduction
Inflammatory diseases are associated with bone pathology, reflected in a higher fracture risk. Serum high-sensitivity CRP is an inflammatory biomarker. We investigated the relationship between CRP and bone mineral density (BMD), hip bone geometry, and incident fractures in the Rotterdam Study, a prospective population-based cohort.
Methods
At baseline, serum high-sensitivity CRP was measured. A weighted genetic risk score was compiled for CRP based on published studies (29 polymorphisms; Illumina HumanHap550 Beadchip genotyping and HapMap imputation). Regression models were reported per standard deviation increase in CRP adjusted for sex, age, and BMI. Complete data was available for 6,386 participants, of whom 1,561 persons sustained a fracture (mean follow-up, 11.6 years).
Results
CRP was associated with a risk for any type of fracture [hazard ratio (HR) = 1.06; 95 % confidence interval (CI), 1.02–1.11], hip fractures (HR = 1.09; 1.02–1.17) and vertebral fractures [odds ratio (OR) = 1.34; 1.14–1.58]. An inverse relationship between CRP levels and section modulus (−0.011 cm
3
; −0.020 to −0.003 cm
3
) was observed. The combined genetic risk score of CRP single nucleotide polymorphisms (SNPs) was associated with serum CRP levels (
p
= 9 × 10
−56
), but not with fracture risk (HR = 1.00; 0.99–1.00;
p
= 0.23).
Conclusions
Serum high-sensitivity CRP is associated with fracture risk and lower bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal. Future studies might reveal what factors truly underlie the relationship between CRP and fracture risk.</abstract><cop>London</cop><pub>Springer London</pub><pmid>24337661</pmid><doi>10.1007/s00198-013-2578-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | Osteoporosis international, 2014-04, Vol.25 (4), p.1247-1254 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Biomarkers Biomarkers - blood Body Mass Index Bone Density - physiology Bone diseases Bones C-Reactive Protein - analysis C-Reactive Protein - genetics C-Reactive Protein - physiology Endocrinology Epidemiology Female Femur Neck - physiopathology Fractures Genotype Humans Incidence Lumbar Vertebrae - physiopathology Male Medicine Medicine & Public Health Mendelian Randomization Analysis Middle Aged Netherlands - epidemiology Original Article Orthopedics Osteoporotic Fractures - blood Osteoporotic Fractures - epidemiology Osteoporotic Fractures - genetics Osteoporotic Fractures - physiopathology Polymorphism, Single Nucleotide Prospective Studies Proteins Rheumatology Risk assessment Risk Assessment - methods |
| title | Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study |
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