Red Blood Cell Transfusion Increases the Risk of Thrombotic Events in Patients with Subarachnoid Hemorrhage
Background and Purpose Red blood cell transfusion (RBCT) may increase the risk of thrombotic events (TE) in patients with subarachnoid hemorrhage (SAH) through changes induced by storage coupled with SAH-related hypercoagulability. We sought to investigate the association between RBCT and the risk o...
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| Veröffentlicht in: | Neurocritical care 2014-02, Vol.20 (1), p.84-90 |
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| creator | Kumar, Monisha A. Boland, Torrey A. Baiou, Mohamed Moussouttas, Michael Herman, Jay H. Bell, Rodney D. Rosenwasser, Robert H. Kasner, Scott E. Dechant, Valerie E. |
| description | Background and Purpose
Red blood cell transfusion (RBCT) may increase the risk of thrombotic events (TE) in patients with subarachnoid hemorrhage (SAH) through changes induced by storage coupled with SAH-related hypercoagulability. We sought to investigate the association between RBCT and the risk of TE in patients with SAH.
Methods
205 consecutive patients with acute, aneurysmal SAH admitted to the neurovascular intensive care unit of a tertiary care, academic medical center between 3/2008 and 7/2009 were enrolled in a retrospective, observational cohort study. TE were defined as the composite of venous thromboembolism (VTE), myocardial infarction (MI), and cerebral infarction noted on brain CT scan. Secondary endpoints included the risk of VTE, poor outcome (modified Rankin score 3–6 at discharge), and in-hospital mortality.
Results
86/205 (42 %) received RBCT. Eighty-eight (43 %) had a thrombotic complication. Forty (34 %) of 119 non-transfused and 48/86 (56 %) transfused patients had a TE (
p
= 0.002). In multivariate analysis, RBCT was associated with more TE by [OR 2.4; 95 % CI (1.2, 4.6);
p
= 0.01], VTE [OR 2.3; 95 % CI (1.0, 5.2);
p
= 0.04], and poor outcome [OR 5.0; 95 % CI (1.9, 12.8);
p
|
| doi_str_mv | 10.1007/s12028-013-9819-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1512334841</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2919539020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-dec0fc475765215ede492842011347b5b28a671f08df4f3401c7b2c930e05c103</originalsourceid><addsrcrecordid>eNqFkV1rFTEQhoNYbK3-AG8k4I03azP52Gwu9VBtoWCpx-uQzc52055NarJb8d-766kKgvRqBuaZdxgeQl4BeweM6ZMCnPGmYiAq04Cp2BNyBErVFTM1PF17CVVthDgkz0u5YYxro9UzcsiF5EKDOSK3V9jRD7uUOrrB3Y5us4uln0tIkZ5Hn9EVLHQakF6FcktTT7dDTmObpuDp6T3GqdAQ6aWbwq_-e5gG-mVuXXZ-iCl09AzHlPPgrvEFOejdruDLh3pMvn483W7OqovPn8437y8qL2UzVR161nupla4VB4UdSsMbyRmAkLpVLW9craFnTdfLXkgGXrfcG8GQKQ9MHJO3-9y7nL7NWCY7huKX71zENBcLCrgQspHwOCqNAcVFLRf0zT_oTZpzXB6x3IBRwjC-3oY95XMqJWNv73IYXf5hgdlVmt1Ls4s0u0qz687rh-S5HbH7s_Hb0gLwPVCWUbzG_Pf0_1N_Akt5oBA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2919539020</pqid></control><display><type>article</type><title>Red Blood Cell Transfusion Increases the Risk of Thrombotic Events in Patients with Subarachnoid Hemorrhage</title><source>MEDLINE</source><source>ProQuest Central (Alumni Edition)</source><source>ProQuest Central UK/Ireland</source><source>SpringerLink Journals - AutoHoldings</source><source>ProQuest Central</source><creator>Kumar, Monisha A. ; Boland, Torrey A. ; Baiou, Mohamed ; Moussouttas, Michael ; Herman, Jay H. ; Bell, Rodney D. ; Rosenwasser, Robert H. ; Kasner, Scott E. ; Dechant, Valerie E.</creator><creatorcontrib>Kumar, Monisha A. ; Boland, Torrey A. ; Baiou, Mohamed ; Moussouttas, Michael ; Herman, Jay H. ; Bell, Rodney D. ; Rosenwasser, Robert H. ; Kasner, Scott E. ; Dechant, Valerie E.</creatorcontrib><description>Background and Purpose
Red blood cell transfusion (RBCT) may increase the risk of thrombotic events (TE) in patients with subarachnoid hemorrhage (SAH) through changes induced by storage coupled with SAH-related hypercoagulability. We sought to investigate the association between RBCT and the risk of TE in patients with SAH.
Methods
205 consecutive patients with acute, aneurysmal SAH admitted to the neurovascular intensive care unit of a tertiary care, academic medical center between 3/2008 and 7/2009 were enrolled in a retrospective, observational cohort study. TE were defined as the composite of venous thromboembolism (VTE), myocardial infarction (MI), and cerebral infarction noted on brain CT scan. Secondary endpoints included the risk of VTE, poor outcome (modified Rankin score 3–6 at discharge), and in-hospital mortality.
Results
86/205 (42 %) received RBCT. Eighty-eight (43 %) had a thrombotic complication. Forty (34 %) of 119 non-transfused and 48/86 (56 %) transfused patients had a TE (
p
= 0.002). In multivariate analysis, RBCT was associated with more TE by [OR 2.4; 95 % CI (1.2, 4.6);
p
= 0.01], VTE [OR 2.3; 95 % CI (1.0, 5.2);
p
= 0.04], and poor outcome [OR 5.0; 95 % CI (1.9, 12.8);
p
< 0.01]. The risk of TE increased by 55 % per unit transfused when controlling for univariate variables. Neither mean nor maximum age of blood was significantly associated with thrombotic risk.
Conclusions
RBCT is associated with an increased risk of TE and VTE in SAH patients. A dose-dependent relationship exists between number of units transfused and thrombosis. Age of blood does not appear to play a role.</description><identifier>ISSN: 1541-6933</identifier><identifier>EISSN: 1556-0961</identifier><identifier>DOI: 10.1007/s12028-013-9819-0</identifier><identifier>PMID: 23423719</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acute Disease ; Aged ; Aneurysms ; Blood ; Cardiovascular disease ; Cerebral Infarction - etiology ; Cerebral Infarction - mortality ; Clinical Protocols ; Critical Care Medicine ; Embolisms ; Erythrocyte Transfusion - adverse effects ; Erythrocyte Transfusion - methods ; Erythrocytes ; Female ; Heart attacks ; Hemoglobin ; Hemorrhage ; Hospital Mortality ; Hospitals ; Humans ; Hypertension ; Intensive ; Internal Medicine ; Intracranial Aneurysm - cerebrospinal fluid ; Intracranial Aneurysm - complications ; Intracranial Aneurysm - diagnostic imaging ; Ischemia ; Leukocytes ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Myocardial Infarction - etiology ; Myocardial Infarction - mortality ; Neurology ; Nitric oxide ; Original Article ; Radiography ; Regression analysis ; Retrospective Studies ; Risk ; Stroke ; Subarachnoid Hemorrhage - etiology ; Subarachnoid Hemorrhage - mortality ; Subarachnoid Hemorrhage - therapy ; Thromboembolism ; Thrombosis ; Treatment Outcome ; Ultrasonic imaging ; Venous Thromboembolism - etiology ; Venous Thromboembolism - mortality</subject><ispartof>Neurocritical care, 2014-02, Vol.20 (1), p.84-90</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>Springer Science+Business Media New York 2013.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-dec0fc475765215ede492842011347b5b28a671f08df4f3401c7b2c930e05c103</citedby><cites>FETCH-LOGICAL-c448t-dec0fc475765215ede492842011347b5b28a671f08df4f3401c7b2c930e05c103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12028-013-9819-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2919539020?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,27924,27925,33530,33531,33744,33745,41488,42557,43659,43805,51319,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23423719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Monisha A.</creatorcontrib><creatorcontrib>Boland, Torrey A.</creatorcontrib><creatorcontrib>Baiou, Mohamed</creatorcontrib><creatorcontrib>Moussouttas, Michael</creatorcontrib><creatorcontrib>Herman, Jay H.</creatorcontrib><creatorcontrib>Bell, Rodney D.</creatorcontrib><creatorcontrib>Rosenwasser, Robert H.</creatorcontrib><creatorcontrib>Kasner, Scott E.</creatorcontrib><creatorcontrib>Dechant, Valerie E.</creatorcontrib><title>Red Blood Cell Transfusion Increases the Risk of Thrombotic Events in Patients with Subarachnoid Hemorrhage</title><title>Neurocritical care</title><addtitle>Neurocrit Care</addtitle><addtitle>Neurocrit Care</addtitle><description>Background and Purpose
Red blood cell transfusion (RBCT) may increase the risk of thrombotic events (TE) in patients with subarachnoid hemorrhage (SAH) through changes induced by storage coupled with SAH-related hypercoagulability. We sought to investigate the association between RBCT and the risk of TE in patients with SAH.
Methods
205 consecutive patients with acute, aneurysmal SAH admitted to the neurovascular intensive care unit of a tertiary care, academic medical center between 3/2008 and 7/2009 were enrolled in a retrospective, observational cohort study. TE were defined as the composite of venous thromboembolism (VTE), myocardial infarction (MI), and cerebral infarction noted on brain CT scan. Secondary endpoints included the risk of VTE, poor outcome (modified Rankin score 3–6 at discharge), and in-hospital mortality.
Results
86/205 (42 %) received RBCT. Eighty-eight (43 %) had a thrombotic complication. Forty (34 %) of 119 non-transfused and 48/86 (56 %) transfused patients had a TE (
p
= 0.002). In multivariate analysis, RBCT was associated with more TE by [OR 2.4; 95 % CI (1.2, 4.6);
p
= 0.01], VTE [OR 2.3; 95 % CI (1.0, 5.2);
p
= 0.04], and poor outcome [OR 5.0; 95 % CI (1.9, 12.8);
p
< 0.01]. The risk of TE increased by 55 % per unit transfused when controlling for univariate variables. Neither mean nor maximum age of blood was significantly associated with thrombotic risk.
Conclusions
RBCT is associated with an increased risk of TE and VTE in SAH patients. A dose-dependent relationship exists between number of units transfused and thrombosis. Age of blood does not appear to play a role.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Aneurysms</subject><subject>Blood</subject><subject>Cardiovascular disease</subject><subject>Cerebral Infarction - etiology</subject><subject>Cerebral Infarction - mortality</subject><subject>Clinical Protocols</subject><subject>Critical Care Medicine</subject><subject>Embolisms</subject><subject>Erythrocyte Transfusion - adverse effects</subject><subject>Erythrocyte Transfusion - methods</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Hemoglobin</subject><subject>Hemorrhage</subject><subject>Hospital Mortality</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Intracranial Aneurysm - cerebrospinal fluid</subject><subject>Intracranial Aneurysm - complications</subject><subject>Intracranial Aneurysm - diagnostic imaging</subject><subject>Ischemia</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - etiology</subject><subject>Myocardial Infarction - mortality</subject><subject>Neurology</subject><subject>Nitric oxide</subject><subject>Original Article</subject><subject>Radiography</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Stroke</subject><subject>Subarachnoid Hemorrhage - etiology</subject><subject>Subarachnoid Hemorrhage - mortality</subject><subject>Subarachnoid Hemorrhage - therapy</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><subject>Venous Thromboembolism - etiology</subject><subject>Venous Thromboembolism - mortality</subject><issn>1541-6933</issn><issn>1556-0961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkV1rFTEQhoNYbK3-AG8k4I03azP52Gwu9VBtoWCpx-uQzc52055NarJb8d-766kKgvRqBuaZdxgeQl4BeweM6ZMCnPGmYiAq04Cp2BNyBErVFTM1PF17CVVthDgkz0u5YYxro9UzcsiF5EKDOSK3V9jRD7uUOrrB3Y5us4uln0tIkZ5Hn9EVLHQakF6FcktTT7dDTmObpuDp6T3GqdAQ6aWbwq_-e5gG-mVuXXZ-iCl09AzHlPPgrvEFOejdruDLh3pMvn483W7OqovPn8437y8qL2UzVR161nupla4VB4UdSsMbyRmAkLpVLW9craFnTdfLXkgGXrfcG8GQKQ9MHJO3-9y7nL7NWCY7huKX71zENBcLCrgQspHwOCqNAcVFLRf0zT_oTZpzXB6x3IBRwjC-3oY95XMqJWNv73IYXf5hgdlVmt1Ls4s0u0qz687rh-S5HbH7s_Hb0gLwPVCWUbzG_Pf0_1N_Akt5oBA</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Kumar, Monisha A.</creator><creator>Boland, Torrey A.</creator><creator>Baiou, Mohamed</creator><creator>Moussouttas, Michael</creator><creator>Herman, Jay H.</creator><creator>Bell, Rodney D.</creator><creator>Rosenwasser, Robert H.</creator><creator>Kasner, Scott E.</creator><creator>Dechant, Valerie E.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20140201</creationdate><title>Red Blood Cell Transfusion Increases the Risk of Thrombotic Events in Patients with Subarachnoid Hemorrhage</title><author>Kumar, Monisha A. ; Boland, Torrey A. ; Baiou, Mohamed ; Moussouttas, Michael ; Herman, Jay H. ; Bell, Rodney D. ; Rosenwasser, Robert H. ; Kasner, Scott E. ; Dechant, Valerie E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-dec0fc475765215ede492842011347b5b28a671f08df4f3401c7b2c930e05c103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Aneurysms</topic><topic>Blood</topic><topic>Cardiovascular disease</topic><topic>Cerebral Infarction - etiology</topic><topic>Cerebral Infarction - mortality</topic><topic>Clinical Protocols</topic><topic>Critical Care Medicine</topic><topic>Embolisms</topic><topic>Erythrocyte Transfusion - adverse effects</topic><topic>Erythrocyte Transfusion - methods</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Hemoglobin</topic><topic>Hemorrhage</topic><topic>Hospital Mortality</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Intracranial Aneurysm - cerebrospinal fluid</topic><topic>Intracranial Aneurysm - complications</topic><topic>Intracranial Aneurysm - diagnostic imaging</topic><topic>Ischemia</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial Infarction - etiology</topic><topic>Myocardial Infarction - mortality</topic><topic>Neurology</topic><topic>Nitric oxide</topic><topic>Original Article</topic><topic>Radiography</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Stroke</topic><topic>Subarachnoid Hemorrhage - etiology</topic><topic>Subarachnoid Hemorrhage - mortality</topic><topic>Subarachnoid Hemorrhage - therapy</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><topic>Treatment Outcome</topic><topic>Ultrasonic imaging</topic><topic>Venous Thromboembolism - etiology</topic><topic>Venous Thromboembolism - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Monisha A.</creatorcontrib><creatorcontrib>Boland, Torrey A.</creatorcontrib><creatorcontrib>Baiou, Mohamed</creatorcontrib><creatorcontrib>Moussouttas, Michael</creatorcontrib><creatorcontrib>Herman, Jay H.</creatorcontrib><creatorcontrib>Bell, Rodney D.</creatorcontrib><creatorcontrib>Rosenwasser, Robert H.</creatorcontrib><creatorcontrib>Kasner, Scott E.</creatorcontrib><creatorcontrib>Dechant, Valerie E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurocritical care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Monisha A.</au><au>Boland, Torrey A.</au><au>Baiou, Mohamed</au><au>Moussouttas, Michael</au><au>Herman, Jay H.</au><au>Bell, Rodney D.</au><au>Rosenwasser, Robert H.</au><au>Kasner, Scott E.</au><au>Dechant, Valerie E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red Blood Cell Transfusion Increases the Risk of Thrombotic Events in Patients with Subarachnoid Hemorrhage</atitle><jtitle>Neurocritical care</jtitle><stitle>Neurocrit Care</stitle><addtitle>Neurocrit Care</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>20</volume><issue>1</issue><spage>84</spage><epage>90</epage><pages>84-90</pages><issn>1541-6933</issn><eissn>1556-0961</eissn><abstract>Background and Purpose
Red blood cell transfusion (RBCT) may increase the risk of thrombotic events (TE) in patients with subarachnoid hemorrhage (SAH) through changes induced by storage coupled with SAH-related hypercoagulability. We sought to investigate the association between RBCT and the risk of TE in patients with SAH.
Methods
205 consecutive patients with acute, aneurysmal SAH admitted to the neurovascular intensive care unit of a tertiary care, academic medical center between 3/2008 and 7/2009 were enrolled in a retrospective, observational cohort study. TE were defined as the composite of venous thromboembolism (VTE), myocardial infarction (MI), and cerebral infarction noted on brain CT scan. Secondary endpoints included the risk of VTE, poor outcome (modified Rankin score 3–6 at discharge), and in-hospital mortality.
Results
86/205 (42 %) received RBCT. Eighty-eight (43 %) had a thrombotic complication. Forty (34 %) of 119 non-transfused and 48/86 (56 %) transfused patients had a TE (
p
= 0.002). In multivariate analysis, RBCT was associated with more TE by [OR 2.4; 95 % CI (1.2, 4.6);
p
= 0.01], VTE [OR 2.3; 95 % CI (1.0, 5.2);
p
= 0.04], and poor outcome [OR 5.0; 95 % CI (1.9, 12.8);
p
< 0.01]. The risk of TE increased by 55 % per unit transfused when controlling for univariate variables. Neither mean nor maximum age of blood was significantly associated with thrombotic risk.
Conclusions
RBCT is associated with an increased risk of TE and VTE in SAH patients. A dose-dependent relationship exists between number of units transfused and thrombosis. Age of blood does not appear to play a role.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23423719</pmid><doi>10.1007/s12028-013-9819-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurocritical care, 2014-02, Vol.20 (1), p.84-90 |
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| language | eng |
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| source | MEDLINE; ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Acute Disease Aged Aneurysms Blood Cardiovascular disease Cerebral Infarction - etiology Cerebral Infarction - mortality Clinical Protocols Critical Care Medicine Embolisms Erythrocyte Transfusion - adverse effects Erythrocyte Transfusion - methods Erythrocytes Female Heart attacks Hemoglobin Hemorrhage Hospital Mortality Hospitals Humans Hypertension Intensive Internal Medicine Intracranial Aneurysm - cerebrospinal fluid Intracranial Aneurysm - complications Intracranial Aneurysm - diagnostic imaging Ischemia Leukocytes Male Medicine Medicine & Public Health Middle Aged Mortality Myocardial Infarction - etiology Myocardial Infarction - mortality Neurology Nitric oxide Original Article Radiography Regression analysis Retrospective Studies Risk Stroke Subarachnoid Hemorrhage - etiology Subarachnoid Hemorrhage - mortality Subarachnoid Hemorrhage - therapy Thromboembolism Thrombosis Treatment Outcome Ultrasonic imaging Venous Thromboembolism - etiology Venous Thromboembolism - mortality |
| title | Red Blood Cell Transfusion Increases the Risk of Thrombotic Events in Patients with Subarachnoid Hemorrhage |
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