Intestinal organoids as tissue surrogates for toxicological and pharmacological studies

Recently developed cell culture protocols have allowed for the derivation of multi-cellular structures dubbed intestinal “organoids” from embryonic stem cells (ESCs), induced pluripotent stem cells (IPSCs), and adult intestinal stem cells (ISCs). These structures resemble in vivo intestinal crypts,...

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Veröffentlicht in:	Biochemical pharmacology 2013-06, Vol.85 (12), p.1721-1726
Hauptverfasser:	Kuratnik, Anton, Giardina, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Animals cell culture colorectal neoplasms Drug-Related Side Effects and Adverse Reactions - pathology Embryonic stem cells Gastrointestinal Diseases - pathology Gastrointestinal Diseases - surgery High throughput screening Humans Induced pluripotent cells induced pluripotent stem cells Induced Pluripotent Stem Cells - transplantation intestinal crypts Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - transplantation Intestinal organoids Intestinal stem cells mice Organoids - cytology Organoids - drug effects Organoids - transplantation pharmacology screening Stem Cell Transplantation - methods tissue repair
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