Pulsed LLLT improves tendon healing in rats: a biochemical, organizational, and functional evaluation
In the last decades, the tendon injuries have increased substantially. Previous results suggested that low-level laser treatment (LLLT) promotes synthesis of extracellular matrix and improves the functional properties of the tendon. The aim of this study was to evaluate the effects of different prot...
Gespeichert in:
| Veröffentlicht in: | Lasers in medical science 2014-03, Vol.29 (2), p.805-811 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 811 |
|---|---|
| container_issue | 2 |
| container_start_page | 805 |
| container_title | Lasers in medical science |
| container_volume | 29 |
| creator | Guerra, Flávia Da Ré Vieira, Cristiano Pedrozo dos Santos de Almeida, Marcos Oliveira, Letícia Prado Claro, Ana Carolina Ferreira Simões, Gustavo Ferreira de Oliveira, Alexandre Leite Rodrigues Pimentel, Edson Rosa |
| description | In the last decades, the tendon injuries have increased substantially. Previous results suggested that low-level laser treatment (LLLT) promotes synthesis of extracellular matrix and improves the functional properties of the tendon. The aim of this study was to evaluate the effects of different protocols of LLLT on partially tenotomized tendons. Adult male rats were divided into the following: G1—intact, G2—injured, G3—injured + LLLT (4 J/cm
2
continuous), G4—injured + LLLT (4 J/cm
2
at 20 Hz). G2, G3, and G4 were euthanized 8 days after injury. G5—injured, G6—injured + LLLT (4 J/cm
2
continuous), and G7—injured + LLL (4 J/cm
2
at 20 Hz until the seventh day and 2 kHz from 8 to 14 days). G5, G6, and G7 were euthanized on the 15th day. Glycosaminoglycan (GAG) level was quantified by dimethylmethylene blue method and analyzed on agarose gel. Toluidine blue (TB) stain was used to observe metachromasy. CatWalk system was used to evaluate gait recovery. Collagen organization was analyzed by polarization microscopy. The GAG level increased in all transected groups, except G5. In G6 and G7, there was a significant increase in GAG in relation to G5. In G3 and G4, the presence of dermatan sulfate band was more prominent than G2. TB stains showed intense metachromasy in the treated groups. Birefringence analysis showed improvement in collagen organization in G7. The gait was significantly improved in G7. In conclusion, pulsed LLLT leads to increased organization of collagen bundles and improved gait recovery. |
| doi_str_mv | 10.1007/s10103-013-1406-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1512332059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3245784751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-430cf8c2eba689f91d660cf202a8d13e5021e95a11cdb7d1872e238679ff371d3</originalsourceid><addsrcrecordid>eNp1kctq3TAQhkVoSU7SPEA3RdBNF3EzI9my3V0IvYEhWaSQndCRxicKtpxKdqB9-urEaSmFrsRovvnn8jP2GuE9AtTnCQFBFoCywBJUIQ7YBktZFQrK2xdsA0I1RdMKPGLHKd0DYK1QHrIjIdtG1NhuGF0vQyLHu6674X58iNMjJT5TcFPgd2QGH3bcBx7NnD5ww7d-snc0emuGMz7FnQn-p5n9FPaxCY73S7BrzOnRDMtT8hV72Zvc5_T5PWHfPn28ufxSdFefv15edIUtoZqLUoLtGytoa1TT9i06pfKPAGEah5IqEEhtZRCt29YOm1qQkI2q276XNTp5wt6tunmP7wulWY8-WRoGE2haksYKhZQCqjajb_9B76cl5rH3FNQolaqqTOFK2TilFKnXD9GPJv7QCHrvgV490NkDvfdAi1zz5ll52Y7k_lT8PnoGxAqknAo7in-1_q_qL7wjkMs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1507136655</pqid></control><display><type>article</type><title>Pulsed LLLT improves tendon healing in rats: a biochemical, organizational, and functional evaluation</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Guerra, Flávia Da Ré ; Vieira, Cristiano Pedrozo ; dos Santos de Almeida, Marcos ; Oliveira, Letícia Prado ; Claro, Ana Carolina Ferreira ; Simões, Gustavo Ferreira ; de Oliveira, Alexandre Leite Rodrigues ; Pimentel, Edson Rosa</creator><creatorcontrib>Guerra, Flávia Da Ré ; Vieira, Cristiano Pedrozo ; dos Santos de Almeida, Marcos ; Oliveira, Letícia Prado ; Claro, Ana Carolina Ferreira ; Simões, Gustavo Ferreira ; de Oliveira, Alexandre Leite Rodrigues ; Pimentel, Edson Rosa</creatorcontrib><description>In the last decades, the tendon injuries have increased substantially. Previous results suggested that low-level laser treatment (LLLT) promotes synthesis of extracellular matrix and improves the functional properties of the tendon. The aim of this study was to evaluate the effects of different protocols of LLLT on partially tenotomized tendons. Adult male rats were divided into the following: G1—intact, G2—injured, G3—injured + LLLT (4 J/cm
2
continuous), G4—injured + LLLT (4 J/cm
2
at 20 Hz). G2, G3, and G4 were euthanized 8 days after injury. G5—injured, G6—injured + LLLT (4 J/cm
2
continuous), and G7—injured + LLL (4 J/cm
2
at 20 Hz until the seventh day and 2 kHz from 8 to 14 days). G5, G6, and G7 were euthanized on the 15th day. Glycosaminoglycan (GAG) level was quantified by dimethylmethylene blue method and analyzed on agarose gel. Toluidine blue (TB) stain was used to observe metachromasy. CatWalk system was used to evaluate gait recovery. Collagen organization was analyzed by polarization microscopy. The GAG level increased in all transected groups, except G5. In G6 and G7, there was a significant increase in GAG in relation to G5. In G3 and G4, the presence of dermatan sulfate band was more prominent than G2. TB stains showed intense metachromasy in the treated groups. Birefringence analysis showed improvement in collagen organization in G7. The gait was significantly improved in G7. In conclusion, pulsed LLLT leads to increased organization of collagen bundles and improved gait recovery.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-013-1406-2</identifier><identifier>PMID: 23982719</identifier><identifier>CODEN: LMSCEZ</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Achilles Tendon - injuries ; Animals ; Biochemistry ; Collagen ; Dentistry ; Glycosaminoglycans - metabolism ; Laser surgery ; Lasers ; Low-Level Light Therapy - instrumentation ; Low-Level Light Therapy - methods ; Male ; Medicine ; Medicine & Public Health ; Microscopy, Polarization ; Optical Devices ; Optics ; Original Article ; Photonics ; Quantum Optics ; Rats, Wistar ; Rehabilitation ; Rodents ; Tendon Injuries - metabolism ; Tendon Injuries - physiopathology ; Tendon Injuries - radiotherapy ; Tendons ; Wound Healing - radiation effects</subject><ispartof>Lasers in medical science, 2014-03, Vol.29 (2), p.805-811</ispartof><rights>Springer-Verlag London 2013</rights><rights>Springer-Verlag London 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-430cf8c2eba689f91d660cf202a8d13e5021e95a11cdb7d1872e238679ff371d3</citedby><cites>FETCH-LOGICAL-c405t-430cf8c2eba689f91d660cf202a8d13e5021e95a11cdb7d1872e238679ff371d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-013-1406-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-013-1406-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23982719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guerra, Flávia Da Ré</creatorcontrib><creatorcontrib>Vieira, Cristiano Pedrozo</creatorcontrib><creatorcontrib>dos Santos de Almeida, Marcos</creatorcontrib><creatorcontrib>Oliveira, Letícia Prado</creatorcontrib><creatorcontrib>Claro, Ana Carolina Ferreira</creatorcontrib><creatorcontrib>Simões, Gustavo Ferreira</creatorcontrib><creatorcontrib>de Oliveira, Alexandre Leite Rodrigues</creatorcontrib><creatorcontrib>Pimentel, Edson Rosa</creatorcontrib><title>Pulsed LLLT improves tendon healing in rats: a biochemical, organizational, and functional evaluation</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>In the last decades, the tendon injuries have increased substantially. Previous results suggested that low-level laser treatment (LLLT) promotes synthesis of extracellular matrix and improves the functional properties of the tendon. The aim of this study was to evaluate the effects of different protocols of LLLT on partially tenotomized tendons. Adult male rats were divided into the following: G1—intact, G2—injured, G3—injured + LLLT (4 J/cm
2
continuous), G4—injured + LLLT (4 J/cm
2
at 20 Hz). G2, G3, and G4 were euthanized 8 days after injury. G5—injured, G6—injured + LLLT (4 J/cm
2
continuous), and G7—injured + LLL (4 J/cm
2
at 20 Hz until the seventh day and 2 kHz from 8 to 14 days). G5, G6, and G7 were euthanized on the 15th day. Glycosaminoglycan (GAG) level was quantified by dimethylmethylene blue method and analyzed on agarose gel. Toluidine blue (TB) stain was used to observe metachromasy. CatWalk system was used to evaluate gait recovery. Collagen organization was analyzed by polarization microscopy. The GAG level increased in all transected groups, except G5. In G6 and G7, there was a significant increase in GAG in relation to G5. In G3 and G4, the presence of dermatan sulfate band was more prominent than G2. TB stains showed intense metachromasy in the treated groups. Birefringence analysis showed improvement in collagen organization in G7. The gait was significantly improved in G7. In conclusion, pulsed LLLT leads to increased organization of collagen bundles and improved gait recovery.</description><subject>Achilles Tendon - injuries</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Collagen</subject><subject>Dentistry</subject><subject>Glycosaminoglycans - metabolism</subject><subject>Laser surgery</subject><subject>Lasers</subject><subject>Low-Level Light Therapy - instrumentation</subject><subject>Low-Level Light Therapy - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microscopy, Polarization</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Photonics</subject><subject>Quantum Optics</subject><subject>Rats, Wistar</subject><subject>Rehabilitation</subject><subject>Rodents</subject><subject>Tendon Injuries - metabolism</subject><subject>Tendon Injuries - physiopathology</subject><subject>Tendon Injuries - radiotherapy</subject><subject>Tendons</subject><subject>Wound Healing - radiation effects</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctq3TAQhkVoSU7SPEA3RdBNF3EzI9my3V0IvYEhWaSQndCRxicKtpxKdqB9-urEaSmFrsRovvnn8jP2GuE9AtTnCQFBFoCywBJUIQ7YBktZFQrK2xdsA0I1RdMKPGLHKd0DYK1QHrIjIdtG1NhuGF0vQyLHu6674X58iNMjJT5TcFPgd2QGH3bcBx7NnD5ww7d-snc0emuGMz7FnQn-p5n9FPaxCY73S7BrzOnRDMtT8hV72Zvc5_T5PWHfPn28ufxSdFefv15edIUtoZqLUoLtGytoa1TT9i06pfKPAGEah5IqEEhtZRCt29YOm1qQkI2q276XNTp5wt6tunmP7wulWY8-WRoGE2haksYKhZQCqjajb_9B76cl5rH3FNQolaqqTOFK2TilFKnXD9GPJv7QCHrvgV490NkDvfdAi1zz5ll52Y7k_lT8PnoGxAqknAo7in-1_q_qL7wjkMs</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Guerra, Flávia Da Ré</creator><creator>Vieira, Cristiano Pedrozo</creator><creator>dos Santos de Almeida, Marcos</creator><creator>Oliveira, Letícia Prado</creator><creator>Claro, Ana Carolina Ferreira</creator><creator>Simões, Gustavo Ferreira</creator><creator>de Oliveira, Alexandre Leite Rodrigues</creator><creator>Pimentel, Edson Rosa</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20140301</creationdate><title>Pulsed LLLT improves tendon healing in rats: a biochemical, organizational, and functional evaluation</title><author>Guerra, Flávia Da Ré ; Vieira, Cristiano Pedrozo ; dos Santos de Almeida, Marcos ; Oliveira, Letícia Prado ; Claro, Ana Carolina Ferreira ; Simões, Gustavo Ferreira ; de Oliveira, Alexandre Leite Rodrigues ; Pimentel, Edson Rosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-430cf8c2eba689f91d660cf202a8d13e5021e95a11cdb7d1872e238679ff371d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Achilles Tendon - injuries</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Collagen</topic><topic>Dentistry</topic><topic>Glycosaminoglycans - metabolism</topic><topic>Laser surgery</topic><topic>Lasers</topic><topic>Low-Level Light Therapy - instrumentation</topic><topic>Low-Level Light Therapy - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microscopy, Polarization</topic><topic>Optical Devices</topic><topic>Optics</topic><topic>Original Article</topic><topic>Photonics</topic><topic>Quantum Optics</topic><topic>Rats, Wistar</topic><topic>Rehabilitation</topic><topic>Rodents</topic><topic>Tendon Injuries - metabolism</topic><topic>Tendon Injuries - physiopathology</topic><topic>Tendon Injuries - radiotherapy</topic><topic>Tendons</topic><topic>Wound Healing - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guerra, Flávia Da Ré</creatorcontrib><creatorcontrib>Vieira, Cristiano Pedrozo</creatorcontrib><creatorcontrib>dos Santos de Almeida, Marcos</creatorcontrib><creatorcontrib>Oliveira, Letícia Prado</creatorcontrib><creatorcontrib>Claro, Ana Carolina Ferreira</creatorcontrib><creatorcontrib>Simões, Gustavo Ferreira</creatorcontrib><creatorcontrib>de Oliveira, Alexandre Leite Rodrigues</creatorcontrib><creatorcontrib>Pimentel, Edson Rosa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guerra, Flávia Da Ré</au><au>Vieira, Cristiano Pedrozo</au><au>dos Santos de Almeida, Marcos</au><au>Oliveira, Letícia Prado</au><au>Claro, Ana Carolina Ferreira</au><au>Simões, Gustavo Ferreira</au><au>de Oliveira, Alexandre Leite Rodrigues</au><au>Pimentel, Edson Rosa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulsed LLLT improves tendon healing in rats: a biochemical, organizational, and functional evaluation</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>29</volume><issue>2</issue><spage>805</spage><epage>811</epage><pages>805-811</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><coden>LMSCEZ</coden><abstract>In the last decades, the tendon injuries have increased substantially. Previous results suggested that low-level laser treatment (LLLT) promotes synthesis of extracellular matrix and improves the functional properties of the tendon. The aim of this study was to evaluate the effects of different protocols of LLLT on partially tenotomized tendons. Adult male rats were divided into the following: G1—intact, G2—injured, G3—injured + LLLT (4 J/cm
2
continuous), G4—injured + LLLT (4 J/cm
2
at 20 Hz). G2, G3, and G4 were euthanized 8 days after injury. G5—injured, G6—injured + LLLT (4 J/cm
2
continuous), and G7—injured + LLL (4 J/cm
2
at 20 Hz until the seventh day and 2 kHz from 8 to 14 days). G5, G6, and G7 were euthanized on the 15th day. Glycosaminoglycan (GAG) level was quantified by dimethylmethylene blue method and analyzed on agarose gel. Toluidine blue (TB) stain was used to observe metachromasy. CatWalk system was used to evaluate gait recovery. Collagen organization was analyzed by polarization microscopy. The GAG level increased in all transected groups, except G5. In G6 and G7, there was a significant increase in GAG in relation to G5. In G3 and G4, the presence of dermatan sulfate band was more prominent than G2. TB stains showed intense metachromasy in the treated groups. Birefringence analysis showed improvement in collagen organization in G7. The gait was significantly improved in G7. In conclusion, pulsed LLLT leads to increased organization of collagen bundles and improved gait recovery.</abstract><cop>London</cop><pub>Springer London</pub><pmid>23982719</pmid><doi>10.1007/s10103-013-1406-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-8921 |
| ispartof | Lasers in medical science, 2014-03, Vol.29 (2), p.805-811 |
| issn | 0268-8921 1435-604X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1512332059 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Achilles Tendon - injuries Animals Biochemistry Collagen Dentistry Glycosaminoglycans - metabolism Laser surgery Lasers Low-Level Light Therapy - instrumentation Low-Level Light Therapy - methods Male Medicine Medicine & Public Health Microscopy, Polarization Optical Devices Optics Original Article Photonics Quantum Optics Rats, Wistar Rehabilitation Rodents Tendon Injuries - metabolism Tendon Injuries - physiopathology Tendon Injuries - radiotherapy Tendons Wound Healing - radiation effects |
| title | Pulsed LLLT improves tendon healing in rats: a biochemical, organizational, and functional evaluation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T16%3A14%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pulsed%20LLLT%20improves%20tendon%20healing%20in%20rats:%20a%20biochemical,%20organizational,%20and%20functional%20evaluation&rft.jtitle=Lasers%20in%20medical%20science&rft.au=Guerra,%20Fl%C3%A1via%20Da%20R%C3%A9&rft.date=2014-03-01&rft.volume=29&rft.issue=2&rft.spage=805&rft.epage=811&rft.pages=805-811&rft.issn=0268-8921&rft.eissn=1435-604X&rft.coden=LMSCEZ&rft_id=info:doi/10.1007/s10103-013-1406-2&rft_dat=%3Cproquest_cross%3E3245784751%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1507136655&rft_id=info:pmid/23982719&rfr_iscdi=true |