Increased fibrinogen, d-dimer and galectin-3 levels in patients with migraine
There are limited studies evaluating the fibrinogen levels in patients with migraine. It remains unknown whether the levels of the haematological marker of thromboembolism, d -dimer, and the levels of galectin-3, which plays an important role in inflammation as a proinflammatory mediator, change dur...
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| Veröffentlicht in: | Neurological sciences 2014-04, Vol.35 (4), p.545-549 |
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| creator | Yucel, Yavuz Tanriverdi, Halis Arıkanoglu, Adalet Varol, Sefer Kaplan, Ibrahim Akil, Esref Celepkolu, Tahsin Uzar, Ertugrul |
| description | There are limited studies evaluating the fibrinogen levels in patients with migraine. It remains unknown whether the levels of the haematological marker of thromboembolism,
d
-dimer, and the levels of galectin-3, which plays an important role in inflammation as a proinflammatory mediator, change during the attacks in patients with migraine. The present study aims to compare galectin-3, fibrinogen and
d
-dimer levels in patients with migraine during the attacks and interictal periods, and to compare galectin-3, fibrinogen and
d
-dimer levels between patients with migraine and healthy controls to investigate the role of these parameters in the pathogenesis of migraine. Fifty-nine patients with migraine and 30 age-gender matched healthy control subjects were enrolled in the study. Blood galectin-3, fibrinogen and
d
-dimer levels were measured in patients with migraine. Patients with migraine had higher levels of galectin-3, fibrinogen and
d
-dimer compared to the healthy controls (
p
0.05). Migraine patients had higher
d
-dimer levels during the attacks compared to the patients in the interictal period in the migraine group (
p
= 0.05). In conclusion, we found increased levels of fibrinogen,
d
-dimer and galectin-3 in patients with migraine compared to the healthy control group. Furthermore, we showed increased galectin-3 levels in patients with migraine, and higher
d
-dimer levels during migraine attacks compared to the interictal periods for the first time. These findings may be associated with the hypercoagulability and neurogenic inflammation during migraine headaches. |
| doi_str_mv | 10.1007/s10072-013-1542-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1512325843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1508424759</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-d634e30b1d015d0d38ded9ffa24ae043a90f7f342848b66728848fe98a60c3ca3</originalsourceid><addsrcrecordid>eNqNkU1LJDEQhsOy4ujoD9jLEtiLB6OVj-6kjzKoK4x40XPIdKpnI93p2aRnxX9vNzMuy4LgpaogT71FeAj5xuGCA-jLPFXBgEvGCyWY-EKOeFEBk0qbr_uZG61m5DjnZwDgistDMhMKCs25PiL3d7FO6DJ62oRVCrFfYzynnvnQYaIuerp2LdZDiEzSFv9gm2mIdOOGgHHI9CUMv2gX1smFiCfkoHFtxtN9n5Onm-vHxU-2fLi9W1wtWT0eHpgvpUIJK-6BFx68NB591TROKIegpKug0Y1UwiizKkstzDg0WBlXQi1rJ-fkbJe7Sf3vLebBdiHX2LYuYr_NlhdcSFEYJT-BglFC6aIa0R__oc_9NsXxIxOlS6WUmAL5jqpTn3PCxm5S6Fx6tRzsJMTutNhRi520WDHufN8nb1cd-r8b7x5GQOyAPD7FNaZ_Tn-Y-gY_5ZVU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1507644423</pqid></control><display><type>article</type><title>Increased fibrinogen, d-dimer and galectin-3 levels in patients with migraine</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Yucel, Yavuz ; Tanriverdi, Halis ; Arıkanoglu, Adalet ; Varol, Sefer ; Kaplan, Ibrahim ; Akil, Esref ; Celepkolu, Tahsin ; Uzar, Ertugrul</creator><creatorcontrib>Yucel, Yavuz ; Tanriverdi, Halis ; Arıkanoglu, Adalet ; Varol, Sefer ; Kaplan, Ibrahim ; Akil, Esref ; Celepkolu, Tahsin ; Uzar, Ertugrul</creatorcontrib><description>There are limited studies evaluating the fibrinogen levels in patients with migraine. It remains unknown whether the levels of the haematological marker of thromboembolism,
d
-dimer, and the levels of galectin-3, which plays an important role in inflammation as a proinflammatory mediator, change during the attacks in patients with migraine. The present study aims to compare galectin-3, fibrinogen and
d
-dimer levels in patients with migraine during the attacks and interictal periods, and to compare galectin-3, fibrinogen and
d
-dimer levels between patients with migraine and healthy controls to investigate the role of these parameters in the pathogenesis of migraine. Fifty-nine patients with migraine and 30 age-gender matched healthy control subjects were enrolled in the study. Blood galectin-3, fibrinogen and
d
-dimer levels were measured in patients with migraine. Patients with migraine had higher levels of galectin-3, fibrinogen and
d
-dimer compared to the healthy controls (
p
< 0.05). No statistically significant difference was found between galectin-3 and fibrinogen levels during the attacks and interictal period in the migraine group (
p
> 0.05). Migraine patients had higher
d
-dimer levels during the attacks compared to the patients in the interictal period in the migraine group (
p
= 0.05). In conclusion, we found increased levels of fibrinogen,
d
-dimer and galectin-3 in patients with migraine compared to the healthy control group. Furthermore, we showed increased galectin-3 levels in patients with migraine, and higher
d
-dimer levels during migraine attacks compared to the interictal periods for the first time. These findings may be associated with the hypercoagulability and neurogenic inflammation during migraine headaches.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-013-1542-2</identifier><identifier>PMID: 24057117</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adult ; Blood ; Female ; Fibrin Fibrinogen Degradation Products - analysis ; Fibrinogen - analysis ; Galectin 3 - blood ; Humans ; Male ; Medicine ; Medicine & Public Health ; Migraine ; Migraine Disorders - blood ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Original Article ; Psychiatry</subject><ispartof>Neurological sciences, 2014-04, Vol.35 (4), p.545-549</ispartof><rights>Springer-Verlag Italia 2013</rights><rights>Springer-Verlag Italia 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-d634e30b1d015d0d38ded9ffa24ae043a90f7f342848b66728848fe98a60c3ca3</citedby><cites>FETCH-LOGICAL-c405t-d634e30b1d015d0d38ded9ffa24ae043a90f7f342848b66728848fe98a60c3ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-013-1542-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-013-1542-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24057117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yucel, Yavuz</creatorcontrib><creatorcontrib>Tanriverdi, Halis</creatorcontrib><creatorcontrib>Arıkanoglu, Adalet</creatorcontrib><creatorcontrib>Varol, Sefer</creatorcontrib><creatorcontrib>Kaplan, Ibrahim</creatorcontrib><creatorcontrib>Akil, Esref</creatorcontrib><creatorcontrib>Celepkolu, Tahsin</creatorcontrib><creatorcontrib>Uzar, Ertugrul</creatorcontrib><title>Increased fibrinogen, d-dimer and galectin-3 levels in patients with migraine</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>There are limited studies evaluating the fibrinogen levels in patients with migraine. It remains unknown whether the levels of the haematological marker of thromboembolism,
d
-dimer, and the levels of galectin-3, which plays an important role in inflammation as a proinflammatory mediator, change during the attacks in patients with migraine. The present study aims to compare galectin-3, fibrinogen and
d
-dimer levels in patients with migraine during the attacks and interictal periods, and to compare galectin-3, fibrinogen and
d
-dimer levels between patients with migraine and healthy controls to investigate the role of these parameters in the pathogenesis of migraine. Fifty-nine patients with migraine and 30 age-gender matched healthy control subjects were enrolled in the study. Blood galectin-3, fibrinogen and
d
-dimer levels were measured in patients with migraine. Patients with migraine had higher levels of galectin-3, fibrinogen and
d
-dimer compared to the healthy controls (
p
< 0.05). No statistically significant difference was found between galectin-3 and fibrinogen levels during the attacks and interictal period in the migraine group (
p
> 0.05). Migraine patients had higher
d
-dimer levels during the attacks compared to the patients in the interictal period in the migraine group (
p
= 0.05). In conclusion, we found increased levels of fibrinogen,
d
-dimer and galectin-3 in patients with migraine compared to the healthy control group. Furthermore, we showed increased galectin-3 levels in patients with migraine, and higher
d
-dimer levels during migraine attacks compared to the interictal periods for the first time. These findings may be associated with the hypercoagulability and neurogenic inflammation during migraine headaches.</description><subject>Adult</subject><subject>Blood</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Fibrinogen - analysis</subject><subject>Galectin 3 - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Migraine</subject><subject>Migraine Disorders - blood</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Psychiatry</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1LJDEQhsOy4ujoD9jLEtiLB6OVj-6kjzKoK4x40XPIdKpnI93p2aRnxX9vNzMuy4LgpaogT71FeAj5xuGCA-jLPFXBgEvGCyWY-EKOeFEBk0qbr_uZG61m5DjnZwDgistDMhMKCs25PiL3d7FO6DJ62oRVCrFfYzynnvnQYaIuerp2LdZDiEzSFv9gm2mIdOOGgHHI9CUMv2gX1smFiCfkoHFtxtN9n5Onm-vHxU-2fLi9W1wtWT0eHpgvpUIJK-6BFx68NB591TROKIegpKug0Y1UwiizKkstzDg0WBlXQi1rJ-fkbJe7Sf3vLebBdiHX2LYuYr_NlhdcSFEYJT-BglFC6aIa0R__oc_9NsXxIxOlS6WUmAL5jqpTn3PCxm5S6Fx6tRzsJMTutNhRi520WDHufN8nb1cd-r8b7x5GQOyAPD7FNaZ_Tn-Y-gY_5ZVU</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Yucel, Yavuz</creator><creator>Tanriverdi, Halis</creator><creator>Arıkanoglu, Adalet</creator><creator>Varol, Sefer</creator><creator>Kaplan, Ibrahim</creator><creator>Akil, Esref</creator><creator>Celepkolu, Tahsin</creator><creator>Uzar, Ertugrul</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Increased fibrinogen, d-dimer and galectin-3 levels in patients with migraine</title><author>Yucel, Yavuz ; Tanriverdi, Halis ; Arıkanoglu, Adalet ; Varol, Sefer ; Kaplan, Ibrahim ; Akil, Esref ; Celepkolu, Tahsin ; Uzar, Ertugrul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-d634e30b1d015d0d38ded9ffa24ae043a90f7f342848b66728848fe98a60c3ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Blood</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Fibrinogen - analysis</topic><topic>Galectin 3 - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Migraine</topic><topic>Migraine Disorders - blood</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yucel, Yavuz</creatorcontrib><creatorcontrib>Tanriverdi, Halis</creatorcontrib><creatorcontrib>Arıkanoglu, Adalet</creatorcontrib><creatorcontrib>Varol, Sefer</creatorcontrib><creatorcontrib>Kaplan, Ibrahim</creatorcontrib><creatorcontrib>Akil, Esref</creatorcontrib><creatorcontrib>Celepkolu, Tahsin</creatorcontrib><creatorcontrib>Uzar, Ertugrul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yucel, Yavuz</au><au>Tanriverdi, Halis</au><au>Arıkanoglu, Adalet</au><au>Varol, Sefer</au><au>Kaplan, Ibrahim</au><au>Akil, Esref</au><au>Celepkolu, Tahsin</au><au>Uzar, Ertugrul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased fibrinogen, d-dimer and galectin-3 levels in patients with migraine</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>35</volume><issue>4</issue><spage>545</spage><epage>549</epage><pages>545-549</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>There are limited studies evaluating the fibrinogen levels in patients with migraine. It remains unknown whether the levels of the haematological marker of thromboembolism,
d
-dimer, and the levels of galectin-3, which plays an important role in inflammation as a proinflammatory mediator, change during the attacks in patients with migraine. The present study aims to compare galectin-3, fibrinogen and
d
-dimer levels in patients with migraine during the attacks and interictal periods, and to compare galectin-3, fibrinogen and
d
-dimer levels between patients with migraine and healthy controls to investigate the role of these parameters in the pathogenesis of migraine. Fifty-nine patients with migraine and 30 age-gender matched healthy control subjects were enrolled in the study. Blood galectin-3, fibrinogen and
d
-dimer levels were measured in patients with migraine. Patients with migraine had higher levels of galectin-3, fibrinogen and
d
-dimer compared to the healthy controls (
p
< 0.05). No statistically significant difference was found between galectin-3 and fibrinogen levels during the attacks and interictal period in the migraine group (
p
> 0.05). Migraine patients had higher
d
-dimer levels during the attacks compared to the patients in the interictal period in the migraine group (
p
= 0.05). In conclusion, we found increased levels of fibrinogen,
d
-dimer and galectin-3 in patients with migraine compared to the healthy control group. Furthermore, we showed increased galectin-3 levels in patients with migraine, and higher
d
-dimer levels during migraine attacks compared to the interictal periods for the first time. These findings may be associated with the hypercoagulability and neurogenic inflammation during migraine headaches.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>24057117</pmid><doi>10.1007/s10072-013-1542-2</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neurological sciences, 2014-04, Vol.35 (4), p.545-549 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Blood Female Fibrin Fibrinogen Degradation Products - analysis Fibrinogen - analysis Galectin 3 - blood Humans Male Medicine Medicine & Public Health Migraine Migraine Disorders - blood Neurology Neuroradiology Neurosciences Neurosurgery Original Article Psychiatry |
| title | Increased fibrinogen, d-dimer and galectin-3 levels in patients with migraine |
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