Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in rabbit
Beta-cryptoxanthin (b-Cr) is a pro-vitamin A and one of the major carotenoids that can be commonly found in mammalian serum and tissues. Foods rich in certain fatty acids are known to be effective to gain a healthy immune system. In the present study, we evaluated the effect of b-Cr on rabbit humora...
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| Veröffentlicht in: | Veterinary research communications 2014-03, Vol.38 (1), p.59-62 |
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| creator | Ghodratizadeh, Soroush Kanbak, Güngör Beyramzadeh, Mojtaba Dikmen, Zeliha Gunnur Memarzadeh, Salar Habibian, Reza |
| description | Beta-cryptoxanthin (b-Cr) is a pro-vitamin A and one of the major carotenoids that can be commonly found in mammalian serum and tissues. Foods rich in certain fatty acids are known to be effective to gain a healthy immune system. In the present study, we evaluated the effect of b-Cr on rabbit humoral and cellular immune responses to have a better vision about the mechanism of effect of carotenoids on immune system. Twenty rabbits were randomly divided into five groups (4 per group): Groups consisted of: 1) control group (normal saline; 2) b-Cr (control); 3) vaccine control; 4) 5 mg/kg b-Cr o.p. + vaccine; 5) 10 mg/kg b-Cr o.p. + vaccine. Blood samples were obtained from the marginal ear artery at three time points: days 0, 14 and 21 of the study. Blood CD4+ and CD8+ lymphocytes and Serum Immunoglobulin and Cytokines content were evaluated. Results show that b-Cr administration increased the blood CD4+ lymphocytes count (P > 0.01). Serum IgG, IgM and IgA levels increased (P > 0.05) following b-Cr administration. b-Cr treatment increased serum IL-4 levels (P > 0.05). According to presented results, b-Cr may increase the humoral immunity in mammals. So, it would possible has a potentially beneficial effect on health and on prevention of the immunity related diseases. |
| doi_str_mv | 10.1007/s11259-013-9584-8 |
| format | Article |
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Foods rich in certain fatty acids are known to be effective to gain a healthy immune system. In the present study, we evaluated the effect of b-Cr on rabbit humoral and cellular immune responses to have a better vision about the mechanism of effect of carotenoids on immune system. Twenty rabbits were randomly divided into five groups (4 per group): Groups consisted of: 1) control group (normal saline; 2) b-Cr (control); 3) vaccine control; 4) 5 mg/kg b-Cr o.p. + vaccine; 5) 10 mg/kg b-Cr o.p. + vaccine. Blood samples were obtained from the marginal ear artery at three time points: days 0, 14 and 21 of the study. Blood CD4+ and CD8+ lymphocytes and Serum Immunoglobulin and Cytokines content were evaluated. Results show that b-Cr administration increased the blood CD4+ lymphocytes count (P > 0.01). Serum IgG, IgM and IgA levels increased (P > 0.05) following b-Cr administration. b-Cr treatment increased serum IL-4 levels (P > 0.05). According to presented results, b-Cr may increase the humoral immunity in mammals. So, it would possible has a potentially beneficial effect on health and on prevention of the immunity related diseases.</description><identifier>ISSN: 0165-7380</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1007/s11259-013-9584-8</identifier><identifier>PMID: 24307458</identifier><language>eng</language><publisher>Dordrecht: Springer-Verlag</publisher><subject>Animals ; beta-cryptoxanthin ; Biomedical and Life Sciences ; CD4-positive T-lymphocytes ; CD4-Positive T-Lymphocytes - drug effects ; CD8-positive T-lymphocytes ; CD8-Positive T-Lymphocytes - drug effects ; cell-mediated immunity ; Cryptoxanthins ; ears ; fatty acids ; foods ; humoral immunity ; Immunity, Cellular - drug effects ; Immunity, Humoral - drug effects ; immunoglobulin A ; immunoglobulin G ; immunoglobulin M ; Immunoglobulins - blood ; Interferon-gamma - blood ; interleukin-4 ; Interleukin-4 - blood ; Life Sciences ; lymphocyte count ; Male ; Myxoma virus - immunology ; Original Article ; rabbits ; Rabbits - immunology ; Random Allocation ; Veterinary Medicine/Veterinary Science ; Viral Vaccines - immunology ; Xanthophylls - pharmacology ; Zoology</subject><ispartof>Veterinary research communications, 2014-03, Vol.38 (1), p.59-62</ispartof><rights>Springer Science+Business Media Dordrecht 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-40acda64811e28061a7f4b96a5e7a46b404675091a89e1405d96a1a21956e0553</citedby><cites>FETCH-LOGICAL-c401t-40acda64811e28061a7f4b96a5e7a46b404675091a89e1405d96a1a21956e0553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11259-013-9584-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11259-013-9584-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24307458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghodratizadeh, Soroush</creatorcontrib><creatorcontrib>Kanbak, Güngör</creatorcontrib><creatorcontrib>Beyramzadeh, Mojtaba</creatorcontrib><creatorcontrib>Dikmen, Zeliha Gunnur</creatorcontrib><creatorcontrib>Memarzadeh, Salar</creatorcontrib><creatorcontrib>Habibian, Reza</creatorcontrib><title>Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in rabbit</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><addtitle>Vet Res Commun</addtitle><description>Beta-cryptoxanthin (b-Cr) is a pro-vitamin A and one of the major carotenoids that can be commonly found in mammalian serum and tissues. Foods rich in certain fatty acids are known to be effective to gain a healthy immune system. In the present study, we evaluated the effect of b-Cr on rabbit humoral and cellular immune responses to have a better vision about the mechanism of effect of carotenoids on immune system. Twenty rabbits were randomly divided into five groups (4 per group): Groups consisted of: 1) control group (normal saline; 2) b-Cr (control); 3) vaccine control; 4) 5 mg/kg b-Cr o.p. + vaccine; 5) 10 mg/kg b-Cr o.p. + vaccine. Blood samples were obtained from the marginal ear artery at three time points: days 0, 14 and 21 of the study. Blood CD4+ and CD8+ lymphocytes and Serum Immunoglobulin and Cytokines content were evaluated. Results show that b-Cr administration increased the blood CD4+ lymphocytes count (P > 0.01). Serum IgG, IgM and IgA levels increased (P > 0.05) following b-Cr administration. b-Cr treatment increased serum IL-4 levels (P > 0.05). According to presented results, b-Cr may increase the humoral immunity in mammals. So, it would possible has a potentially beneficial effect on health and on prevention of the immunity related diseases.</description><subject>Animals</subject><subject>beta-cryptoxanthin</subject><subject>Biomedical and Life Sciences</subject><subject>CD4-positive T-lymphocytes</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>CD8-positive T-lymphocytes</subject><subject>CD8-Positive T-Lymphocytes - drug effects</subject><subject>cell-mediated immunity</subject><subject>Cryptoxanthins</subject><subject>ears</subject><subject>fatty acids</subject><subject>foods</subject><subject>humoral immunity</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunity, Humoral - drug effects</subject><subject>immunoglobulin A</subject><subject>immunoglobulin G</subject><subject>immunoglobulin M</subject><subject>Immunoglobulins - blood</subject><subject>Interferon-gamma - blood</subject><subject>interleukin-4</subject><subject>Interleukin-4 - blood</subject><subject>Life Sciences</subject><subject>lymphocyte count</subject><subject>Male</subject><subject>Myxoma virus - immunology</subject><subject>Original Article</subject><subject>rabbits</subject><subject>Rabbits - immunology</subject><subject>Random Allocation</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>Viral Vaccines - immunology</subject><subject>Xanthophylls - pharmacology</subject><subject>Zoology</subject><issn>0165-7380</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1TAQhS0EorctD8AGvGQTmPG_l6gqUKkSi1J1aTmJ06ZK7IudSO1r8SB9JnyVwhKxmsX5ztHoI-QtwkcE0J8KIpO2AeSNlUY05gXZodS80UKol2QHqGSjuYEjclzKPQBYA_w1OWKCgxbS7MjN-TCEbqFpoJ3PaQkxjT19-tV0-XG_pAcfl7sx0hRpF6ZpnXymPvb0bp1T9hMd53mNgeZQ9imWQCuafduOyyl5NfiphDfP94Rcfzn_cfatufz-9eLs82XTCcClEeC73ithEAMzoNDrQbRWeRm0F6oVIJSWYNEbG1CA7GuGnqGVKoCU_IR82Hb3Of1cQ1ncPJbDqz6GtBaHEhlnXCn8DxRAGas4VBQ3tMuplBwGt8_j7POjQ3AH9W5T76p6d1DvTO28e55f2zn0fxt_XFeAbUCpUbwN2d2nNcdq55-r77fS4JPzt3ks7vqKQVUBgGCZ5r8BL56XIw</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Ghodratizadeh, Soroush</creator><creator>Kanbak, Güngör</creator><creator>Beyramzadeh, Mojtaba</creator><creator>Dikmen, Zeliha Gunnur</creator><creator>Memarzadeh, Salar</creator><creator>Habibian, Reza</creator><general>Springer-Verlag</general><general>Springer Netherlands</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20140301</creationdate><title>Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in rabbit</title><author>Ghodratizadeh, Soroush ; Kanbak, Güngör ; Beyramzadeh, Mojtaba ; Dikmen, Zeliha Gunnur ; Memarzadeh, Salar ; Habibian, Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-40acda64811e28061a7f4b96a5e7a46b404675091a89e1405d96a1a21956e0553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>beta-cryptoxanthin</topic><topic>Biomedical and Life Sciences</topic><topic>CD4-positive T-lymphocytes</topic><topic>CD4-Positive T-Lymphocytes - drug effects</topic><topic>CD8-positive T-lymphocytes</topic><topic>CD8-Positive T-Lymphocytes - drug effects</topic><topic>cell-mediated immunity</topic><topic>Cryptoxanthins</topic><topic>ears</topic><topic>fatty acids</topic><topic>foods</topic><topic>humoral immunity</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunity, Humoral - drug effects</topic><topic>immunoglobulin A</topic><topic>immunoglobulin G</topic><topic>immunoglobulin M</topic><topic>Immunoglobulins - blood</topic><topic>Interferon-gamma - blood</topic><topic>interleukin-4</topic><topic>Interleukin-4 - blood</topic><topic>Life Sciences</topic><topic>lymphocyte count</topic><topic>Male</topic><topic>Myxoma virus - immunology</topic><topic>Original Article</topic><topic>rabbits</topic><topic>Rabbits - immunology</topic><topic>Random Allocation</topic><topic>Veterinary Medicine/Veterinary Science</topic><topic>Viral Vaccines - immunology</topic><topic>Xanthophylls - pharmacology</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghodratizadeh, Soroush</creatorcontrib><creatorcontrib>Kanbak, Güngör</creatorcontrib><creatorcontrib>Beyramzadeh, Mojtaba</creatorcontrib><creatorcontrib>Dikmen, Zeliha Gunnur</creatorcontrib><creatorcontrib>Memarzadeh, Salar</creatorcontrib><creatorcontrib>Habibian, Reza</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Veterinary research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghodratizadeh, Soroush</au><au>Kanbak, Güngör</au><au>Beyramzadeh, Mojtaba</au><au>Dikmen, Zeliha Gunnur</au><au>Memarzadeh, Salar</au><au>Habibian, Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in rabbit</atitle><jtitle>Veterinary research communications</jtitle><stitle>Vet Res Commun</stitle><addtitle>Vet Res Commun</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>38</volume><issue>1</issue><spage>59</spage><epage>62</epage><pages>59-62</pages><issn>0165-7380</issn><eissn>1573-7446</eissn><abstract>Beta-cryptoxanthin (b-Cr) is a pro-vitamin A and one of the major carotenoids that can be commonly found in mammalian serum and tissues. Foods rich in certain fatty acids are known to be effective to gain a healthy immune system. In the present study, we evaluated the effect of b-Cr on rabbit humoral and cellular immune responses to have a better vision about the mechanism of effect of carotenoids on immune system. Twenty rabbits were randomly divided into five groups (4 per group): Groups consisted of: 1) control group (normal saline; 2) b-Cr (control); 3) vaccine control; 4) 5 mg/kg b-Cr o.p. + vaccine; 5) 10 mg/kg b-Cr o.p. + vaccine. Blood samples were obtained from the marginal ear artery at three time points: days 0, 14 and 21 of the study. Blood CD4+ and CD8+ lymphocytes and Serum Immunoglobulin and Cytokines content were evaluated. Results show that b-Cr administration increased the blood CD4+ lymphocytes count (P > 0.01). Serum IgG, IgM and IgA levels increased (P > 0.05) following b-Cr administration. b-Cr treatment increased serum IL-4 levels (P > 0.05). According to presented results, b-Cr may increase the humoral immunity in mammals. So, it would possible has a potentially beneficial effect on health and on prevention of the immunity related diseases.</abstract><cop>Dordrecht</cop><pub>Springer-Verlag</pub><pmid>24307458</pmid><doi>10.1007/s11259-013-9584-8</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals beta-cryptoxanthin Biomedical and Life Sciences CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - drug effects CD8-positive T-lymphocytes CD8-Positive T-Lymphocytes - drug effects cell-mediated immunity Cryptoxanthins ears fatty acids foods humoral immunity Immunity, Cellular - drug effects Immunity, Humoral - drug effects immunoglobulin A immunoglobulin G immunoglobulin M Immunoglobulins - blood Interferon-gamma - blood interleukin-4 Interleukin-4 - blood Life Sciences lymphocyte count Male Myxoma virus - immunology Original Article rabbits Rabbits - immunology Random Allocation Veterinary Medicine/Veterinary Science Viral Vaccines - immunology Xanthophylls - pharmacology Zoology |
| title | Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in rabbit |
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