Human rhinovirus and disease severity in children
To evaluate retrospectively human rhinovirus (HRV) infections in children up to 5 years old and factors involved in disease severity. Nasopharyngeal aspirates from 434 children presenting a broad range of respiratory infection symptoms and severity degrees were tested for presence of HRV and 8 other...
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| Veröffentlicht in: | Pediatrics (Evanston) 2014-02, Vol.133 (2), p.e312-e321 |
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| creator | Costa, Lourenço Faria Queiróz, Divina Aparecida Oliveira Lopes da Silveira, Hélio Bernardino Neto, Morun de Paula, Nayhanne Tizzo Oliveira, Thelma Fátima Mattos Silva Tolardo, Aline Lavado Yokosawa, Jonny |
| description | To evaluate retrospectively human rhinovirus (HRV) infections in children up to 5 years old and factors involved in disease severity.
Nasopharyngeal aspirates from 434 children presenting a broad range of respiratory infection symptoms and severity degrees were tested for presence of HRV and 8 other respiratory viruses. Presence of host risk factors was also assessed.
HRV was detected in 181 (41.7%) samples, in 107 of them as the only agent and in 74 as coinfections, mostly with respiratory syncytial virus (RSV; 43.2%). Moderate to severe symptoms were observed in 28.9% (31/107) single infections and in 51.3% (38/74) coinfections (P = .004). Multivariate analyses showed association of coinfections with lower respiratory tract symptoms and some parameters of disease severity, such as hospitalization. In coinfections, RSV was the most important virus associated with severe disease. Prematurity, cardiomyopathies, and noninfectious respiratory diseases were comorbidities that also were associated with disease severity (P = .007).
Our study showed that HRV was a common pathogen of respiratory disease in children and was also involved in severe cases, causing symptoms of the lower respiratory tract. Severe disease in HRV infections were caused mainly by presence of RSV in coinfections, prematurity, congenital heart disease, and noninfectious respiratory disease. |
| doi_str_mv | 10.1542/peds.2013-2216 |
| format | Article |
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Nasopharyngeal aspirates from 434 children presenting a broad range of respiratory infection symptoms and severity degrees were tested for presence of HRV and 8 other respiratory viruses. Presence of host risk factors was also assessed.
HRV was detected in 181 (41.7%) samples, in 107 of them as the only agent and in 74 as coinfections, mostly with respiratory syncytial virus (RSV; 43.2%). Moderate to severe symptoms were observed in 28.9% (31/107) single infections and in 51.3% (38/74) coinfections (P = .004). Multivariate analyses showed association of coinfections with lower respiratory tract symptoms and some parameters of disease severity, such as hospitalization. In coinfections, RSV was the most important virus associated with severe disease. Prematurity, cardiomyopathies, and noninfectious respiratory diseases were comorbidities that also were associated with disease severity (P = .007).
Our study showed that HRV was a common pathogen of respiratory disease in children and was also involved in severe cases, causing symptoms of the lower respiratory tract. Severe disease in HRV infections were caused mainly by presence of RSV in coinfections, prematurity, congenital heart disease, and noninfectious respiratory disease.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2013-2216</identifier><identifier>PMID: 24420808</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Child, Preschool ; Children ; Children & youth ; Female ; Health aspects ; Human rhinovirus ; Humans ; Infant ; Influence ; Male ; Multivariate analysis ; Pediatrics ; Picornaviridae Infections - diagnosis ; Respiratory diseases ; Respiratory syncytial virus ; Respiratory tract infections ; Respiratory Tract Infections - diagnosis ; Respiratory Tract Infections - virology ; Retrospective Studies ; Rhinovirus - isolation & purification ; Rhinoviruses ; Risk Factors ; Severity of Illness Index ; Viral infections</subject><ispartof>Pediatrics (Evanston), 2014-02, Vol.133 (2), p.e312-e321</ispartof><rights>Copyright American Academy of Pediatrics Feb 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-e0d89bedcc9c1b13df867e207e6f6a438f9aa61727fb811f55667da6212d88be3</citedby><cites>FETCH-LOGICAL-c394t-e0d89bedcc9c1b13df867e207e6f6a438f9aa61727fb811f55667da6212d88be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24420808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costa, Lourenço Faria</creatorcontrib><creatorcontrib>Queiróz, Divina Aparecida Oliveira</creatorcontrib><creatorcontrib>Lopes da Silveira, Hélio</creatorcontrib><creatorcontrib>Bernardino Neto, Morun</creatorcontrib><creatorcontrib>de Paula, Nayhanne Tizzo</creatorcontrib><creatorcontrib>Oliveira, Thelma Fátima Mattos Silva</creatorcontrib><creatorcontrib>Tolardo, Aline Lavado</creatorcontrib><creatorcontrib>Yokosawa, Jonny</creatorcontrib><title>Human rhinovirus and disease severity in children</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>To evaluate retrospectively human rhinovirus (HRV) infections in children up to 5 years old and factors involved in disease severity.
Nasopharyngeal aspirates from 434 children presenting a broad range of respiratory infection symptoms and severity degrees were tested for presence of HRV and 8 other respiratory viruses. Presence of host risk factors was also assessed.
HRV was detected in 181 (41.7%) samples, in 107 of them as the only agent and in 74 as coinfections, mostly with respiratory syncytial virus (RSV; 43.2%). Moderate to severe symptoms were observed in 28.9% (31/107) single infections and in 51.3% (38/74) coinfections (P = .004). Multivariate analyses showed association of coinfections with lower respiratory tract symptoms and some parameters of disease severity, such as hospitalization. In coinfections, RSV was the most important virus associated with severe disease. Prematurity, cardiomyopathies, and noninfectious respiratory diseases were comorbidities that also were associated with disease severity (P = .007).
Our study showed that HRV was a common pathogen of respiratory disease in children and was also involved in severe cases, causing symptoms of the lower respiratory tract. Severe disease in HRV infections were caused mainly by presence of RSV in coinfections, prematurity, congenital heart disease, and noninfectious respiratory disease.</description><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Female</subject><subject>Health aspects</subject><subject>Human rhinovirus</subject><subject>Humans</subject><subject>Infant</subject><subject>Influence</subject><subject>Male</subject><subject>Multivariate analysis</subject><subject>Pediatrics</subject><subject>Picornaviridae Infections - diagnosis</subject><subject>Respiratory diseases</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory tract infections</subject><subject>Respiratory Tract Infections - diagnosis</subject><subject>Respiratory Tract Infections - virology</subject><subject>Retrospective Studies</subject><subject>Rhinovirus - isolation & purification</subject><subject>Rhinoviruses</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Viral infections</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0b9P3DAUwHELFZWDdmWsInXpkuM9_4ozohMtlZBY2tly7BcwyjlXO0Hlv2-iowxdOnn5-NlPX8YuEbaoJL86UChbDihqzlGfsA1Ca2rJG_WObQAE1hJAnbHzUp4AQKqGv2dnXEoOBsyG4e28d6nKjzGNzzHPpXIpVCEWcoWqQs-U4_RSxVT5xziETOkDO-3dUOjj63nBfn69-bG7re_uv33fXd_VXrRyqgmCaTsK3rceOxShN7ohDg3pXjspTN86p7HhTd8ZxF4prZvgNEcejOlIXLAvx7mHPP6aqUx2H4unYXCJxrlYVMgFFxrM_6lspYDlzZV-_oc-jXNOyyKrUq1uUItF1Uf14AayMfkxTfR78uMw0APZZc_dvb0WDegWQeHit0fv81hKpt4ecty7_GIR7NrJrp3s2smunZYLn16_MXd7Cm_8bxjxBy11i1o</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Costa, Lourenço Faria</creator><creator>Queiróz, Divina Aparecida Oliveira</creator><creator>Lopes da Silveira, Hélio</creator><creator>Bernardino Neto, Morun</creator><creator>de Paula, Nayhanne Tizzo</creator><creator>Oliveira, Thelma Fátima Mattos Silva</creator><creator>Tolardo, Aline Lavado</creator><creator>Yokosawa, Jonny</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>201402</creationdate><title>Human rhinovirus and disease severity in children</title><author>Costa, Lourenço Faria ; Queiróz, Divina Aparecida Oliveira ; Lopes da Silveira, Hélio ; Bernardino Neto, Morun ; de Paula, Nayhanne Tizzo ; Oliveira, Thelma Fátima Mattos Silva ; Tolardo, Aline Lavado ; Yokosawa, Jonny</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-e0d89bedcc9c1b13df867e207e6f6a438f9aa61727fb811f55667da6212d88be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Female</topic><topic>Health aspects</topic><topic>Human rhinovirus</topic><topic>Humans</topic><topic>Infant</topic><topic>Influence</topic><topic>Male</topic><topic>Multivariate analysis</topic><topic>Pediatrics</topic><topic>Picornaviridae Infections - diagnosis</topic><topic>Respiratory diseases</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory tract infections</topic><topic>Respiratory Tract Infections - diagnosis</topic><topic>Respiratory Tract Infections - virology</topic><topic>Retrospective Studies</topic><topic>Rhinovirus - isolation & purification</topic><topic>Rhinoviruses</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costa, Lourenço Faria</creatorcontrib><creatorcontrib>Queiróz, Divina Aparecida Oliveira</creatorcontrib><creatorcontrib>Lopes da Silveira, Hélio</creatorcontrib><creatorcontrib>Bernardino Neto, Morun</creatorcontrib><creatorcontrib>de Paula, Nayhanne Tizzo</creatorcontrib><creatorcontrib>Oliveira, Thelma Fátima Mattos Silva</creatorcontrib><creatorcontrib>Tolardo, Aline Lavado</creatorcontrib><creatorcontrib>Yokosawa, Jonny</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costa, Lourenço Faria</au><au>Queiróz, Divina Aparecida Oliveira</au><au>Lopes da Silveira, Hélio</au><au>Bernardino Neto, Morun</au><au>de Paula, Nayhanne Tizzo</au><au>Oliveira, Thelma Fátima Mattos Silva</au><au>Tolardo, Aline Lavado</au><au>Yokosawa, Jonny</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human rhinovirus and disease severity in children</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2014-02</date><risdate>2014</risdate><volume>133</volume><issue>2</issue><spage>e312</spage><epage>e321</epage><pages>e312-e321</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>To evaluate retrospectively human rhinovirus (HRV) infections in children up to 5 years old and factors involved in disease severity.
Nasopharyngeal aspirates from 434 children presenting a broad range of respiratory infection symptoms and severity degrees were tested for presence of HRV and 8 other respiratory viruses. Presence of host risk factors was also assessed.
HRV was detected in 181 (41.7%) samples, in 107 of them as the only agent and in 74 as coinfections, mostly with respiratory syncytial virus (RSV; 43.2%). Moderate to severe symptoms were observed in 28.9% (31/107) single infections and in 51.3% (38/74) coinfections (P = .004). Multivariate analyses showed association of coinfections with lower respiratory tract symptoms and some parameters of disease severity, such as hospitalization. In coinfections, RSV was the most important virus associated with severe disease. Prematurity, cardiomyopathies, and noninfectious respiratory diseases were comorbidities that also were associated with disease severity (P = .007).
Our study showed that HRV was a common pathogen of respiratory disease in children and was also involved in severe cases, causing symptoms of the lower respiratory tract. Severe disease in HRV infections were caused mainly by presence of RSV in coinfections, prematurity, congenital heart disease, and noninfectious respiratory disease.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>24420808</pmid><doi>10.1542/peds.2013-2216</doi></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Child, Preschool Children Children & youth Female Health aspects Human rhinovirus Humans Infant Influence Male Multivariate analysis Pediatrics Picornaviridae Infections - diagnosis Respiratory diseases Respiratory syncytial virus Respiratory tract infections Respiratory Tract Infections - diagnosis Respiratory Tract Infections - virology Retrospective Studies Rhinovirus - isolation & purification Rhinoviruses Risk Factors Severity of Illness Index Viral infections |
| title | Human rhinovirus and disease severity in children |
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