Discovery of chemotherapy‐associated ovarian cancer antigens by interrogating memory T cells

According to the immunogenic cell death hypothesis, clinical chemotherapy treatments may result in CD8+ and CD4+ T‐cell responses against tumor cells. To discover chemotherapy‐associated antigens (CAAs), T cells derived from ovarian cancer (OC) patients (who had been treated with appropriate chemoth...

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Veröffentlicht in:	International Journal of Cancer. Journal International Du Cancer 2014-04, Vol.134 (8), p.1823-1834
Hauptverfasser:	Paroli, Marino, Bellati, Filippo, Videtta, Melissa, Focaccetti, Chiara, Mancone, Carmine, Donato, Tiziana, Antonilli, Morena, Perniola, Giorgia, Accapezzato, Daniele, Napoletano, Chiara, Nuti, Marianna, Bartolazzi, Armando, Panici, Pierluigi Benedetti, Tripodi, Marco, Palombo, Fabio, Barnaba, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens Antigens, Neoplasm - immunology Apoptosis Apoptosis - immunology Biological and medical sciences Cancer Cancer therapies CD8-Positive T-Lymphocytes - immunology Cell Survival Chemotherapy chemotherapy associated antigens Dendritic Cells - immunology Female Female genital diseases Gynecology. Andrology. Obstetrics Human health and pathology Humans Hypotheses Immunologic Memory - immunology Immunology Interferon-gamma - biosynthesis Interleukin-17 - biosynthesis Life Sciences Lymphocytes Medical research Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - immunology Proteins Questioning reverse immunology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization T cell receptors Th1 cells Th1 Cells - immunology Th17 cells tumor biomarkers Tumor Cells, Cultured Tumors
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