Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients
End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST ge...
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| Veröffentlicht in: | Clinical biochemistry 2014-04, Vol.47 (6), p.398-403 |
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| creator | Vekic, Jelena Zeljkovic, Aleksandra Jelic-Ivanovic, Zorana Damjanovic, Tatjana Suvakov, Sonja Matic, Marija Savic-Radojevic, Ana Simic, Tatjana Spasojevic-Kalimanovska, Vesna Gojkovic, Tamara Spasic, Slavica Dimkovic, Nada |
| description | End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST gene polymorphism and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses in ESRD.
GSTM1, T1, and P1 genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism in 160 patients undergoing hemodialysis. LDL and HDL subclasses were separated by gradient gel electrophoresis and biochemical parameters were measured by routine laboratory methods.
GSTM1-positive patients had higher proportion of small, dense LDL III particles than those with GSTM1-null genotype (P |
| doi_str_mv | 10.1016/j.clinbiochem.2013.11.011 |
| format | Article |
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GSTM1, T1, and P1 genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism in 160 patients undergoing hemodialysis. LDL and HDL subclasses were separated by gradient gel electrophoresis and biochemical parameters were measured by routine laboratory methods.
GSTM1-positive patients had higher proportion of small, dense LDL III particles than those with GSTM1-null genotype (P<0.05). Similarly, GSTP1-Ile/Ile patients had higher proportion of LDL III (P<0.05), but more HDL 2b and less HDL 3a particles than GSTP1-Ile/Val and Val/Val carriers (P<0.05). LDL subclass distribution in smokers with GSTM1-null genotype was shifted towards smaller particles, as compared to GSTM1-positive and GSTM1-null non-smokers. Smokers with GSTP1-Ile/Val and Val/Val genotypes had smaller LDL size than their non-smoking counterparts (P<0.05). Both smokers and non-smokers with GSTP1 Ile/Ile genotype had more LDL III particles than non-smokers carrying Val allele. Non-smokers with GSTP1 Ile/Ile genotype had more HDL 2b subclasses than non-smokers with GSTP1-Ile/Val and Val/Val (P<0.05), but less HDL 3a particles than smokers with GSTP1-Ile/Val and Val/Val genotypes (P<0.05). GSTT1 gene polymorphism had no effect on lipoprotein subclass distributions.
Our results demonstrate significant associations between low activity GST genotypes and proatherogenic lipoprotein particles in hemodialysis patients which might further increase their cardiovascular disease risk.
•ESRD is characterized by profound dyslipidemia and enhanced oxidative stress.•GST gene polymorphism modulates enzymatic activity and influences CVD risk.•GST gene polymorphism affects lipoprotein subclass distribution in ESRD.•Observed associations are further aggravated by gene-smoking interactions.]]></description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2013.11.011</identifier><identifier>PMID: 24291050</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cardiovascular disease risk ; Dense LDL ; End-stage renal disease ; Female ; Genetic Association Studies ; Glutathione S-Transferase pi - genetics ; Glutathione Transferase - genetics ; Glutathione-S-transferase polymorphism ; HDL subclasses ; Humans ; Lipoproteins - classification ; Lipoproteins, HDL ; Lipoproteins, LDL ; Male ; Middle Aged ; Polymorphism, Genetic ; Renal Dialysis ; Small ; Smoking - genetics</subject><ispartof>Clinical biochemistry, 2014-04, Vol.47 (6), p.398-403</ispartof><rights>2013 The Canadian Society of Clinical Chemists</rights><rights>Copyright © 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-46a62a1f500bef113b86df757c957faa7967cd461258b93de337a26ffea93f2a3</citedby><cites>FETCH-LOGICAL-c377t-46a62a1f500bef113b86df757c957faa7967cd461258b93de337a26ffea93f2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinbiochem.2013.11.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24291050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vekic, Jelena</creatorcontrib><creatorcontrib>Zeljkovic, Aleksandra</creatorcontrib><creatorcontrib>Jelic-Ivanovic, Zorana</creatorcontrib><creatorcontrib>Damjanovic, Tatjana</creatorcontrib><creatorcontrib>Suvakov, Sonja</creatorcontrib><creatorcontrib>Matic, Marija</creatorcontrib><creatorcontrib>Savic-Radojevic, Ana</creatorcontrib><creatorcontrib>Simic, Tatjana</creatorcontrib><creatorcontrib>Spasojevic-Kalimanovska, Vesna</creatorcontrib><creatorcontrib>Gojkovic, Tamara</creatorcontrib><creatorcontrib>Spasic, Slavica</creatorcontrib><creatorcontrib>Dimkovic, Nada</creatorcontrib><title>Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description><![CDATA[End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST gene polymorphism and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses in ESRD.
GSTM1, T1, and P1 genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism in 160 patients undergoing hemodialysis. LDL and HDL subclasses were separated by gradient gel electrophoresis and biochemical parameters were measured by routine laboratory methods.
GSTM1-positive patients had higher proportion of small, dense LDL III particles than those with GSTM1-null genotype (P<0.05). Similarly, GSTP1-Ile/Ile patients had higher proportion of LDL III (P<0.05), but more HDL 2b and less HDL 3a particles than GSTP1-Ile/Val and Val/Val carriers (P<0.05). LDL subclass distribution in smokers with GSTM1-null genotype was shifted towards smaller particles, as compared to GSTM1-positive and GSTM1-null non-smokers. Smokers with GSTP1-Ile/Val and Val/Val genotypes had smaller LDL size than their non-smoking counterparts (P<0.05). Both smokers and non-smokers with GSTP1 Ile/Ile genotype had more LDL III particles than non-smokers carrying Val allele. Non-smokers with GSTP1 Ile/Ile genotype had more HDL 2b subclasses than non-smokers with GSTP1-Ile/Val and Val/Val (P<0.05), but less HDL 3a particles than smokers with GSTP1-Ile/Val and Val/Val genotypes (P<0.05). GSTT1 gene polymorphism had no effect on lipoprotein subclass distributions.
Our results demonstrate significant associations between low activity GST genotypes and proatherogenic lipoprotein particles in hemodialysis patients which might further increase their cardiovascular disease risk.
•ESRD is characterized by profound dyslipidemia and enhanced oxidative stress.•GST gene polymorphism modulates enzymatic activity and influences CVD risk.•GST gene polymorphism affects lipoprotein subclass distribution in ESRD.•Observed associations are further aggravated by gene-smoking interactions.]]></description><subject>Cardiovascular disease risk</subject><subject>Dense LDL</subject><subject>End-stage renal disease</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Glutathione S-Transferase pi - genetics</subject><subject>Glutathione Transferase - genetics</subject><subject>Glutathione-S-transferase polymorphism</subject><subject>HDL subclasses</subject><subject>Humans</subject><subject>Lipoproteins - classification</subject><subject>Lipoproteins, HDL</subject><subject>Lipoproteins, LDL</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Renal Dialysis</subject><subject>Small</subject><subject>Smoking - genetics</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv1DAQha0KRLeFv1CZG5cEj72JN8dqRQGpEofC2XKccderJA4eB2n_fV1tQRx7Gj3pvXkzH2MfQdQgoP18rN0Y5j5Ed8CplgJUDVALgAu2gZ1WleyUesM2Qoiu6kCKS3ZFdCxSbnftO3Ypt7ID0YgNm2-Jogs2hzjz6PnjuGabD0Vh9VDlZGfymCwhf8QZ-RLH0xTTcgg0cTsPfAxLXFLMGGZOa-9GS4TEiyqnxSHY8USB-FIKcM70nr31diT88DKv2a-7Lz_336r7H1-_72_vK6e0ztW2ta204BshevQAqt-1g9eNdl2jvbW6a7Ubti3IZtd3akCltJWt92g75aVV1-zTeW-57feKlM0UyOE42hnjSgYakLJQAl2s3dnqUiRK6M2SwmTTyYAwz7jN0fyH2zzjNgCm4C7Zm5eatZ9w-Jf8y7cY9mcDlmf_BEyGXAHhcAgJXTZDDK-oeQKqOJod</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Vekic, Jelena</creator><creator>Zeljkovic, Aleksandra</creator><creator>Jelic-Ivanovic, Zorana</creator><creator>Damjanovic, Tatjana</creator><creator>Suvakov, Sonja</creator><creator>Matic, Marija</creator><creator>Savic-Radojevic, Ana</creator><creator>Simic, Tatjana</creator><creator>Spasojevic-Kalimanovska, Vesna</creator><creator>Gojkovic, Tamara</creator><creator>Spasic, Slavica</creator><creator>Dimkovic, Nada</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients</title><author>Vekic, Jelena ; Zeljkovic, Aleksandra ; Jelic-Ivanovic, Zorana ; Damjanovic, Tatjana ; Suvakov, Sonja ; Matic, Marija ; Savic-Radojevic, Ana ; Simic, Tatjana ; Spasojevic-Kalimanovska, Vesna ; Gojkovic, Tamara ; Spasic, Slavica ; Dimkovic, Nada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-46a62a1f500bef113b86df757c957faa7967cd461258b93de337a26ffea93f2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cardiovascular disease risk</topic><topic>Dense LDL</topic><topic>End-stage renal disease</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Glutathione S-Transferase pi - genetics</topic><topic>Glutathione Transferase - genetics</topic><topic>Glutathione-S-transferase polymorphism</topic><topic>HDL subclasses</topic><topic>Humans</topic><topic>Lipoproteins - classification</topic><topic>Lipoproteins, HDL</topic><topic>Lipoproteins, LDL</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Renal Dialysis</topic><topic>Small</topic><topic>Smoking - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vekic, Jelena</creatorcontrib><creatorcontrib>Zeljkovic, Aleksandra</creatorcontrib><creatorcontrib>Jelic-Ivanovic, Zorana</creatorcontrib><creatorcontrib>Damjanovic, Tatjana</creatorcontrib><creatorcontrib>Suvakov, Sonja</creatorcontrib><creatorcontrib>Matic, Marija</creatorcontrib><creatorcontrib>Savic-Radojevic, Ana</creatorcontrib><creatorcontrib>Simic, Tatjana</creatorcontrib><creatorcontrib>Spasojevic-Kalimanovska, Vesna</creatorcontrib><creatorcontrib>Gojkovic, Tamara</creatorcontrib><creatorcontrib>Spasic, Slavica</creatorcontrib><creatorcontrib>Dimkovic, Nada</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vekic, Jelena</au><au>Zeljkovic, Aleksandra</au><au>Jelic-Ivanovic, Zorana</au><au>Damjanovic, Tatjana</au><au>Suvakov, Sonja</au><au>Matic, Marija</au><au>Savic-Radojevic, Ana</au><au>Simic, Tatjana</au><au>Spasojevic-Kalimanovska, Vesna</au><au>Gojkovic, Tamara</au><au>Spasic, Slavica</au><au>Dimkovic, Nada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>47</volume><issue>6</issue><spage>398</spage><epage>403</epage><pages>398-403</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract><![CDATA[End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST gene polymorphism and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses in ESRD.
GSTM1, T1, and P1 genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism in 160 patients undergoing hemodialysis. LDL and HDL subclasses were separated by gradient gel electrophoresis and biochemical parameters were measured by routine laboratory methods.
GSTM1-positive patients had higher proportion of small, dense LDL III particles than those with GSTM1-null genotype (P<0.05). Similarly, GSTP1-Ile/Ile patients had higher proportion of LDL III (P<0.05), but more HDL 2b and less HDL 3a particles than GSTP1-Ile/Val and Val/Val carriers (P<0.05). LDL subclass distribution in smokers with GSTM1-null genotype was shifted towards smaller particles, as compared to GSTM1-positive and GSTM1-null non-smokers. Smokers with GSTP1-Ile/Val and Val/Val genotypes had smaller LDL size than their non-smoking counterparts (P<0.05). Both smokers and non-smokers with GSTP1 Ile/Ile genotype had more LDL III particles than non-smokers carrying Val allele. Non-smokers with GSTP1 Ile/Ile genotype had more HDL 2b subclasses than non-smokers with GSTP1-Ile/Val and Val/Val (P<0.05), but less HDL 3a particles than smokers with GSTP1-Ile/Val and Val/Val genotypes (P<0.05). GSTT1 gene polymorphism had no effect on lipoprotein subclass distributions.
Our results demonstrate significant associations between low activity GST genotypes and proatherogenic lipoprotein particles in hemodialysis patients which might further increase their cardiovascular disease risk.
•ESRD is characterized by profound dyslipidemia and enhanced oxidative stress.•GST gene polymorphism modulates enzymatic activity and influences CVD risk.•GST gene polymorphism affects lipoprotein subclass distribution in ESRD.•Observed associations are further aggravated by gene-smoking interactions.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24291050</pmid><doi>10.1016/j.clinbiochem.2013.11.011</doi><tpages>6</tpages></addata></record> |
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| subjects | Cardiovascular disease risk Dense LDL End-stage renal disease Female Genetic Association Studies Glutathione S-Transferase pi - genetics Glutathione Transferase - genetics Glutathione-S-transferase polymorphism HDL subclasses Humans Lipoproteins - classification Lipoproteins, HDL Lipoproteins, LDL Male Middle Aged Polymorphism, Genetic Renal Dialysis Small Smoking - genetics |
| title | Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients |
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