FBW7 increases chemosensitivity in hepatocellular carcinoma cells through suppression of epithelial-mesenchymal transition

BACKGROUND: FBW7 is a tumor suppressor which regulates a network of proteins with central roles in cell division, cell growth and differentiation. This study aimed to evaluate the role of FBW7in chemosensitivity and epithelial-mesenchymal transition (EMT) in different hepatocellular carcinoma (HCC)...

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Veröffentlicht in:	Hepatobiliary & pancreatic diseases international 2014-04, Vol.13 (2), p.184-191
Hauptverfasser:	Yu, Jun, Zhang, Wu, Gao, Feng, Liu, Yuan-Xing, Chen, Zhi-Yun, Cheng, Long-Yu, Xie, Shang-Fen, Zheng, Shu-Sen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Cadherins - metabolism carcinoma Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Movement - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug doxorubicin Doxorubicin - pharmacology drug drug resistance Drug Resistance, Neoplasm Endocrinology & Metabolism epithelial-mesenchymal Epithelial-Mesenchymal Transition F-Box Proteins - genetics F-Box Proteins - metabolism F-Box-WD Repeat-Containing Protein 7 FBW7 Gastroenterology and Hepatology Gene Expression Regulation, Neoplastic hepatocellular hepatocellular carcinoma Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Mutation Neoplasm Invasiveness resistance RNA Interference Transfection transition Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Vimentin - metabolism
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