Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function

Protein degradation by the ubiquitin-proteasome system in neurons depends on the correct delivery of the proteasome complex. In neurodegenerative diseases, aggregation and accumulation of proteins in axons link transport defects with degradation impairments; however, the transport properties of prot...

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Veröffentlicht in:	Journal of cell science 2014-04, Vol.127 (Pt 7), p.1537-1549
Hauptverfasser:	Otero, Maria G, Alloatti, Matías, Cromberg, Lucas E, Almenar-Queralt, Angels, Encalada, Sandra E, Pozo Devoto, Victorio M, Bruno, Luciana, Goldstein, Lawrence S B, Falzone, Tomás L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonal Transport - physiology Axons - metabolism Biological Transport Cells, Cultured Hippocampus - cytology Intracellular Membranes - metabolism Mice Mice, Inbred C57BL Proteasome Endopeptidase Complex - metabolism Sciatic Nerve - cytology Synaptic Vesicles - metabolism Synaptosomes - metabolism
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