Can Treatment of Nocturia Increase Testosterone Level in Men With Late Onset Hypogonadism?
Objective To assess the effect of desmopressin on serum testosterone level in men with nocturia and late onset hypogonadism. Methods We prospectively enrolled men with nocturia and symptoms of late onset hypogonadism. Desmopressin (0.1 mg) was administered once daily to patients for 12 weeks, and we...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2014-04, Vol.83 (4), p.837-842 |
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| container_title | Urology (Ridgewood, N.J.) |
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| creator | Kim, Jong Wook Chae, Ji Yun Kim, Jin Wook Yoon, Cheol Yong Oh, Mi Mi Park, Hong Seok Kim, Je Jong Moon, Du Geon |
| description | Objective To assess the effect of desmopressin on serum testosterone level in men with nocturia and late onset hypogonadism. Methods We prospectively enrolled men with nocturia and symptoms of late onset hypogonadism. Desmopressin (0.1 mg) was administered once daily to patients for 12 weeks, and we then compared serum testosterone levels, electrolytes, frequency volume chart indices, and changes in the International Prostate Symptom Score (IPSS), International Index of Erectile Function, and Aging Male's Symptom scales before and after treatment. Patients with a history of cardiovascular disease or hyponatremia, those using hypnotics, and those who had primary hypogonadism or hypogonadotrophic hypogonadism were excluded from the study. Results Sixty-two men (mean age, 68.4 years) completed pre- and post-treatment questionnaires and underwent laboratory testing. At the end of the study, the testosterone levels in men with low testosterone levels ( |
| doi_str_mv | 10.1016/j.urology.2013.12.060 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1512224428</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0090429514000533</els_id><sourcerecordid>1512224428</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-803b0b883b546abd96d3ae1bfbf02523c34069fde21defa093fa0ae21ceb92f53</originalsourceid><addsrcrecordid>eNpFkV2L1DAUhoMo7rj6E5TcCN60nnx1mxtFBnUXRvfCEcGbkKana8Y2mU3ahfn3ZphRbxISnjcnPC8hLxnUDFjzdlcvKY7x7lBzYKJmvIYGHpEVU_yq0lqrx2QFoKGSXKsL8iznHQA0TXP1lFxw2bQglVyRn2sb6DahnScMM40D_RrdvCRv6U1w5T4j3WKeY54xxYB0gw84Uh_oFwz0h59_0Y2dkd6GjDO9PuzjXQy293l6_5w8GeyY8cV5vyTfP33crq-rze3nm_WHTeWElnPVguiga1vRKdnYrtdNLyyybugG4IoLJyQ0euiRsx4HC1qUxZaTw07zQYlL8ub07j7F-6X81Uw-OxxHGzAu2TDFOOdS8rag6oS6FHNOOJh98pNNB8PAHLWanTlrNUethnFTtJbcq_OIpZuw_5f667EAr8-Azc6OQ7LB-fyfayVTGnjh3p04LEIePCbjRh98ifzGA-ZdXFIorgwzuUw2344NHgtkspSnhBB_ALjzmEk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1512224428</pqid></control><display><type>article</type><title>Can Treatment of Nocturia Increase Testosterone Level in Men With Late Onset Hypogonadism?</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Kim, Jong Wook ; Chae, Ji Yun ; Kim, Jin Wook ; Yoon, Cheol Yong ; Oh, Mi Mi ; Park, Hong Seok ; Kim, Je Jong ; Moon, Du Geon</creator><creatorcontrib>Kim, Jong Wook ; Chae, Ji Yun ; Kim, Jin Wook ; Yoon, Cheol Yong ; Oh, Mi Mi ; Park, Hong Seok ; Kim, Je Jong ; Moon, Du Geon</creatorcontrib><description>Objective To assess the effect of desmopressin on serum testosterone level in men with nocturia and late onset hypogonadism. Methods We prospectively enrolled men with nocturia and symptoms of late onset hypogonadism. Desmopressin (0.1 mg) was administered once daily to patients for 12 weeks, and we then compared serum testosterone levels, electrolytes, frequency volume chart indices, and changes in the International Prostate Symptom Score (IPSS), International Index of Erectile Function, and Aging Male's Symptom scales before and after treatment. Patients with a history of cardiovascular disease or hyponatremia, those using hypnotics, and those who had primary hypogonadism or hypogonadotrophic hypogonadism were excluded from the study. Results Sixty-two men (mean age, 68.4 years) completed pre- and post-treatment questionnaires and underwent laboratory testing. At the end of the study, the testosterone levels in men with low testosterone levels (<3.5 ng/mL) increased after the 12-week desmopressin treatment (2.85 ± 0.58 to 3.97 ± 1.44 ng/mL; P = .001). Mean scores had decreased from 17.7 to 13.9 (IPSS), 3.8 to 3.2 (IPSS-Quality of Life), and 33.7 to 31.1 (Aging Male's Symptom). On the frequency volume chart, nocturnal urine volume, nocturnal polyuria index, actual number of nocturia events, nocturia index, and nocturnal bladder capacity index were significantly decreased. Conclusion Desmopressin improved nocturia and other urinary symptoms. Moreover, serum testosterone levels increased significantly in men with low testosterone levels after 12-week desmopressin treatment.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/j.urology.2013.12.060</identifier><identifier>PMID: 24680454</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Aged ; Aging ; Biological and medical sciences ; Deamino Arginine Vasopressin - therapeutic use ; Electrolytes - metabolism ; Humans ; Hypogonadism - blood ; Hypogonadism - complications ; Hypogonadism - drug therapy ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nocturia - complications ; Nocturia - drug therapy ; Penile Erection ; Prospective Studies ; Quality of Life ; Surveys and Questionnaires ; Testosterone - blood ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland ; Urology</subject><ispartof>Urology (Ridgewood, N.J.), 2014-04, Vol.83 (4), p.837-842</ispartof><rights>Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-803b0b883b546abd96d3ae1bfbf02523c34069fde21defa093fa0ae21ceb92f53</citedby><cites>FETCH-LOGICAL-c394t-803b0b883b546abd96d3ae1bfbf02523c34069fde21defa093fa0ae21ceb92f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28415902$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24680454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jong Wook</creatorcontrib><creatorcontrib>Chae, Ji Yun</creatorcontrib><creatorcontrib>Kim, Jin Wook</creatorcontrib><creatorcontrib>Yoon, Cheol Yong</creatorcontrib><creatorcontrib>Oh, Mi Mi</creatorcontrib><creatorcontrib>Park, Hong Seok</creatorcontrib><creatorcontrib>Kim, Je Jong</creatorcontrib><creatorcontrib>Moon, Du Geon</creatorcontrib><title>Can Treatment of Nocturia Increase Testosterone Level in Men With Late Onset Hypogonadism?</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>Objective To assess the effect of desmopressin on serum testosterone level in men with nocturia and late onset hypogonadism. Methods We prospectively enrolled men with nocturia and symptoms of late onset hypogonadism. Desmopressin (0.1 mg) was administered once daily to patients for 12 weeks, and we then compared serum testosterone levels, electrolytes, frequency volume chart indices, and changes in the International Prostate Symptom Score (IPSS), International Index of Erectile Function, and Aging Male's Symptom scales before and after treatment. Patients with a history of cardiovascular disease or hyponatremia, those using hypnotics, and those who had primary hypogonadism or hypogonadotrophic hypogonadism were excluded from the study. Results Sixty-two men (mean age, 68.4 years) completed pre- and post-treatment questionnaires and underwent laboratory testing. At the end of the study, the testosterone levels in men with low testosterone levels (<3.5 ng/mL) increased after the 12-week desmopressin treatment (2.85 ± 0.58 to 3.97 ± 1.44 ng/mL; P = .001). Mean scores had decreased from 17.7 to 13.9 (IPSS), 3.8 to 3.2 (IPSS-Quality of Life), and 33.7 to 31.1 (Aging Male's Symptom). On the frequency volume chart, nocturnal urine volume, nocturnal polyuria index, actual number of nocturia events, nocturia index, and nocturnal bladder capacity index were significantly decreased. Conclusion Desmopressin improved nocturia and other urinary symptoms. Moreover, serum testosterone levels increased significantly in men with low testosterone levels after 12-week desmopressin treatment.</description><subject>Aged</subject><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Deamino Arginine Vasopressin - therapeutic use</subject><subject>Electrolytes - metabolism</subject><subject>Humans</subject><subject>Hypogonadism - blood</subject><subject>Hypogonadism - complications</subject><subject>Hypogonadism - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nocturia - complications</subject><subject>Nocturia - drug therapy</subject><subject>Penile Erection</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Surveys and Questionnaires</subject><subject>Testosterone - blood</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><subject>Urology</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkV2L1DAUhoMo7rj6E5TcCN60nnx1mxtFBnUXRvfCEcGbkKana8Y2mU3ahfn3ZphRbxISnjcnPC8hLxnUDFjzdlcvKY7x7lBzYKJmvIYGHpEVU_yq0lqrx2QFoKGSXKsL8iznHQA0TXP1lFxw2bQglVyRn2sb6DahnScMM40D_RrdvCRv6U1w5T4j3WKeY54xxYB0gw84Uh_oFwz0h59_0Y2dkd6GjDO9PuzjXQy293l6_5w8GeyY8cV5vyTfP33crq-rze3nm_WHTeWElnPVguiga1vRKdnYrtdNLyyybugG4IoLJyQ0euiRsx4HC1qUxZaTw07zQYlL8ub07j7F-6X81Uw-OxxHGzAu2TDFOOdS8rag6oS6FHNOOJh98pNNB8PAHLWanTlrNUethnFTtJbcq_OIpZuw_5f667EAr8-Azc6OQ7LB-fyfayVTGnjh3p04LEIePCbjRh98ifzGA-ZdXFIorgwzuUw2344NHgtkspSnhBB_ALjzmEk</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Kim, Jong Wook</creator><creator>Chae, Ji Yun</creator><creator>Kim, Jin Wook</creator><creator>Yoon, Cheol Yong</creator><creator>Oh, Mi Mi</creator><creator>Park, Hong Seok</creator><creator>Kim, Je Jong</creator><creator>Moon, Du Geon</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Can Treatment of Nocturia Increase Testosterone Level in Men With Late Onset Hypogonadism?</title><author>Kim, Jong Wook ; Chae, Ji Yun ; Kim, Jin Wook ; Yoon, Cheol Yong ; Oh, Mi Mi ; Park, Hong Seok ; Kim, Je Jong ; Moon, Du Geon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-803b0b883b546abd96d3ae1bfbf02523c34069fde21defa093fa0ae21ceb92f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Deamino Arginine Vasopressin - therapeutic use</topic><topic>Electrolytes - metabolism</topic><topic>Humans</topic><topic>Hypogonadism - blood</topic><topic>Hypogonadism - complications</topic><topic>Hypogonadism - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nocturia - complications</topic><topic>Nocturia - drug therapy</topic><topic>Penile Erection</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Surveys and Questionnaires</topic><topic>Testosterone - blood</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jong Wook</creatorcontrib><creatorcontrib>Chae, Ji Yun</creatorcontrib><creatorcontrib>Kim, Jin Wook</creatorcontrib><creatorcontrib>Yoon, Cheol Yong</creatorcontrib><creatorcontrib>Oh, Mi Mi</creatorcontrib><creatorcontrib>Park, Hong Seok</creatorcontrib><creatorcontrib>Kim, Je Jong</creatorcontrib><creatorcontrib>Moon, Du Geon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jong Wook</au><au>Chae, Ji Yun</au><au>Kim, Jin Wook</au><au>Yoon, Cheol Yong</au><au>Oh, Mi Mi</au><au>Park, Hong Seok</au><au>Kim, Je Jong</au><au>Moon, Du Geon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can Treatment of Nocturia Increase Testosterone Level in Men With Late Onset Hypogonadism?</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>83</volume><issue>4</issue><spage>837</spage><epage>842</epage><pages>837-842</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>Objective To assess the effect of desmopressin on serum testosterone level in men with nocturia and late onset hypogonadism. Methods We prospectively enrolled men with nocturia and symptoms of late onset hypogonadism. Desmopressin (0.1 mg) was administered once daily to patients for 12 weeks, and we then compared serum testosterone levels, electrolytes, frequency volume chart indices, and changes in the International Prostate Symptom Score (IPSS), International Index of Erectile Function, and Aging Male's Symptom scales before and after treatment. Patients with a history of cardiovascular disease or hyponatremia, those using hypnotics, and those who had primary hypogonadism or hypogonadotrophic hypogonadism were excluded from the study. Results Sixty-two men (mean age, 68.4 years) completed pre- and post-treatment questionnaires and underwent laboratory testing. At the end of the study, the testosterone levels in men with low testosterone levels (<3.5 ng/mL) increased after the 12-week desmopressin treatment (2.85 ± 0.58 to 3.97 ± 1.44 ng/mL; P = .001). Mean scores had decreased from 17.7 to 13.9 (IPSS), 3.8 to 3.2 (IPSS-Quality of Life), and 33.7 to 31.1 (Aging Male's Symptom). On the frequency volume chart, nocturnal urine volume, nocturnal polyuria index, actual number of nocturia events, nocturia index, and nocturnal bladder capacity index were significantly decreased. Conclusion Desmopressin improved nocturia and other urinary symptoms. Moreover, serum testosterone levels increased significantly in men with low testosterone levels after 12-week desmopressin treatment.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>24680454</pmid><doi>10.1016/j.urology.2013.12.060</doi><tpages>6</tpages></addata></record> |
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| ispartof | Urology (Ridgewood, N.J.), 2014-04, Vol.83 (4), p.837-842 |
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| subjects | Aged Aging Biological and medical sciences Deamino Arginine Vasopressin - therapeutic use Electrolytes - metabolism Humans Hypogonadism - blood Hypogonadism - complications Hypogonadism - drug therapy Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nocturia - complications Nocturia - drug therapy Penile Erection Prospective Studies Quality of Life Surveys and Questionnaires Testosterone - blood Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Urology |
| title | Can Treatment of Nocturia Increase Testosterone Level in Men With Late Onset Hypogonadism? |
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