Amygdala kindling disrupts trace and delay fear conditioning with parallel changes in Fos protein expression throughout the limbic brain
Highlights • We studied the effect of short- and long-term kindling on fear learning and memory. • Kindling disrupted conditioned fear in a stimulation- and task-specific manner. • Kindling also decreased Fos expression in several brain regions. • Kindling-induced disruptions in conditioned fear wer...
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| Veröffentlicht in: | Neuroscience 2014-04, Vol.265, p.158-171 |
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| container_title | Neuroscience |
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| creator | Botterill, J.J Fournier, N.M Guskjolen, A.J Lussier, A.L Marks, W.N Kalynchuk, L.E |
| description | Highlights • We studied the effect of short- and long-term kindling on fear learning and memory. • Kindling disrupted conditioned fear in a stimulation- and task-specific manner. • Kindling also decreased Fos expression in several brain regions. • Kindling-induced disruptions in conditioned fear were correlated with dampened Fos expression. • Kindling promotes functional changes within the hippocampus and amygdala. |
| doi_str_mv | 10.1016/j.neuroscience.2014.01.040 |
| format | Article |
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Psychology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; hippocampus ; kindling ; Kindling, Neurologic - physiology ; Limbic System - metabolism ; Limbic System - physiopathology ; Male ; Medical sciences ; memory ; Nervous system (semeiology, syndromes) ; Neurology ; Proto-Oncogene Proteins c-fos - metabolism ; Rats ; Rats, Long-Evans ; temporal lobe epilepsy ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2014-04, Vol.265, p.158-171</ispartof><rights>IBRO</rights><rights>2014 IBRO</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 IBRO. Published by Elsevier Ltd. 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Psychology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>hippocampus</subject><subject>kindling</subject><subject>Kindling, Neurologic - physiology</subject><subject>Limbic System - metabolism</subject><subject>Limbic System - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>memory</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>temporal lobe epilepsy</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksuKFDEUhoMoTjv6ChIEwU2VudXNhTCMMyoMuFDBXUglp7rTk0qVSUqn38DHNkW3F1yZTc7iO7f_Pwg9o6SkhNYv96WHJUxRW_AaSkaoKAktiSD30Ia2DS-aSoj7aEM4qQtRMXaGHsW4J_lVgj9EZ0yItu7qaoN-XIyHrVFO4VvrjbN-i42NYZlTxCkoDVh5gw04dcADqID15I1NdvIr-t2mHZ5VUM6Bw3qn_BYith5fTxHPYUqQY7ibA8SYU3DahWnZ7qYl5RCws2NvNe6Dsv4xejAoF-HJ6T9Hn6-vPl2-K24-vH1_eXFTaFFXqWCdqHReg3Z937bVIChvuOnqWkDVDV3Hm54SPgA0YBjtQPW8GShrgQwMmOL8HL041s3jfV0gJjnaqME55WFaoqQVZYwJ1jUZfXVEdRY7BhjkHOyowkFSIlcn5F7-7YRcnZCEyuxETn566rP0I5jfqb-kz8DzE6CiVm4Iymsb_3CtYE1NV-7NkYOsyjcLQZ7aGRtAJ2km-3_zvP6njM5u29z5Fg4Q99MSfNZdUhmZJPLjejvr6VCRr6amX_hPtLzFYQ</recordid><startdate>20140418</startdate><enddate>20140418</enddate><creator>Botterill, J.J</creator><creator>Fournier, N.M</creator><creator>Guskjolen, A.J</creator><creator>Lussier, A.L</creator><creator>Marks, W.N</creator><creator>Kalynchuk, L.E</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140418</creationdate><title>Amygdala kindling disrupts trace and delay fear conditioning with parallel changes in Fos protein expression throughout the limbic brain</title><author>Botterill, J.J ; Fournier, N.M ; Guskjolen, A.J ; Lussier, A.L ; Marks, W.N ; Kalynchuk, L.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-2945c00519bb885f41373d9664e59f9937b103fee7ed219eab37f128e0f2e2a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>amygdala</topic><topic>Amygdala - metabolism</topic><topic>Amygdala - physiopathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Conditioning, Classical - physiology</topic><topic>Electric Stimulation</topic><topic>Fear - physiology</topic><topic>fear conditioning</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. 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| subjects | amygdala Amygdala - metabolism Amygdala - physiopathology Animals Biological and medical sciences Brain - metabolism Conditioning, Classical - physiology Electric Stimulation Fear - physiology fear conditioning Fundamental and applied biological sciences. Psychology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hippocampus kindling Kindling, Neurologic - physiology Limbic System - metabolism Limbic System - physiopathology Male Medical sciences memory Nervous system (semeiology, syndromes) Neurology Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Long-Evans temporal lobe epilepsy Vertebrates: nervous system and sense organs |
| title | Amygdala kindling disrupts trace and delay fear conditioning with parallel changes in Fos protein expression throughout the limbic brain |
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