FETOTOXIC POTENTIAL OF GENERAL ANAESTHESIA IN RELATION TO PREGNANCY

FETOTOXIC POTENTIAL OF GENERAL ANAESTHESIA IN RELATION TO PREGNANCY

Fifty-three infants with neural tube defects and 97 with other major congenital abnormalities have been reviewed. In only one case did the mother receive an anaesthetic before or during pregnancy and this anaesthetic is unlikely to have played any part in the outcome. The anaesthetic history was rec...

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Veröffentlicht in:British journal of anaesthesia : BJA 1987-04, Vol.59 (4), p.449-454
Hauptverfasser: KONIECZKO, K.M., CHAPPLE, J.C., NUNN, J.F.
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities, Drug-Induced - etiology
Adult
Anesthesia, General - adverse effects
Anesthetics - adverse effects
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Female
Humans
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Neural Tube Defects - chemically induced
Pharmacology. Drug treatments
Pregnancy - drug effects
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container_end_page 454
container_issue 4
container_start_page 449
container_title British journal of anaesthesia : BJA
container_volume 59
creator KONIECZKO, K.M.
CHAPPLE, J.C.
NUNN, J.F.
description Fifty-three infants with neural tube defects and 97 with other major congenital abnormalities have been reviewed. In only one case did the mother receive an anaesthetic before or during pregnancy and this anaesthetic is unlikely to have played any part in the outcome. The anaesthetic history was recorded for 471 mothers who booked consecutively for their confinements. Seventy-two women received 76 anaesthetics, 70 before the last menstrual period and six during pregnancy. The corrected annual incidence of anaesthesia was about 20% (14% related to fertility). There were no fetal abnormalities, but two miscarriages in the women anaesthetized during pregnancy. There was one abnormal baby delivered to a women anaesthetized more than 12 weeks before the last menstrual period.
doi_str_mv 10.1093/bja/59.4.449
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subjects Abnormalities, Drug-Induced - etiology
Adult
Anesthesia, General - adverse effects
Anesthetics - adverse effects
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Female
Humans
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Neural Tube Defects - chemically induced
Pharmacology. Drug treatments
Pregnancy - drug effects
title FETOTOXIC POTENTIAL OF GENERAL ANAESTHESIA IN RELATION TO PREGNANCY
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