Differentiation of Human Epidermal Neural Crest Stem Cells (hEPI-NCSC) into Virtually Homogenous Populations of Dopaminergic Neurons

Here we provide a protocol for the directed differentiation of hEPI-NCSC into midbrain dopaminergic neurons, which degenerate in Parkinson’s disease. hEPI-NCSC are neural crest-derived multipotent stem cells that persist into adulthood in the bulge of hair follicles. The experimental design is disti...

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Veröffentlicht in:	Stem cell reviews 2014-04, Vol.10 (2), p.316-326
Hauptverfasser:	Narytnyk, Alla, Verdon, Bernard, Loughney, Andrew, Sweeney, Michele, Clewes, Oliver, Taggart, Michael J., Sieber-Blum, Maya
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedical Engineering and Bioengineering Cell Biology Cell Culture Techniques Cell Differentiation Cells, Cultured Dopaminergic Neurons - cytology Dopaminergic Neurons - metabolism Epidermal Cells Humans Life Sciences Neural Crest - cytology Neural Stem Cells - physiology Regenerative Medicine/Tissue Engineering Stem Cells Substantia Nigra - cytology
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