Altered response to the selective serotonin reuptake inhibitor escitalopram in mice heterozygous for the serotonin transporter: an electrophysiological and neurochemical study

A serotonin (5-HT) transporter (5-HTT; SERT) polymorphism has been associated with depressive states and poor responses to selective serotonin reuptake inhibitors (SSRIs). Given the similar attenuation of SERT activity in SERT+/− mice and in humans with short allele(s) of SERT in its promoter region...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The international journal of neuropsychopharmacology 2012-04, Vol.15 (3), p.349-361
Hauptverfasser:	Guiard, Bruno P., Mansari, Mostafa El, Murphy, Dennis L., Blier, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - physiology Central Nervous System Agents - pharmacology Citalopram - pharmacology Dorsal Raphe Nucleus - drug effects Dorsal Raphe Nucleus - physiology Extracellular Space - metabolism Hippocampus - drug effects Hippocampus - physiology Male Mice, Transgenic Neurons - drug effects Neurons - physiology Piperazines - pharmacology Potassium Chloride - pharmacology Pyramidal Cells - drug effects Pyramidal Cells - physiology Pyridines - pharmacology Receptor, Serotonin, 5-HT1A - metabolism Serotonergic Neurons - drug effects Serotonergic Neurons - physiology Serotonin - metabolism Serotonin 5-HT1 Receptor Antagonists - pharmacology Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin Uptake Inhibitors - pharmacology Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!