Is ex vivo microdissection testicular sperm extraction indicated for infertile men undergoing radical orchiectomy for testicular cancer? Case report and literature review
Objective To report a case of an infertile man with nonobstructive azoospermia who underwent simultaneous radical orchiectomy for testicular cancer and testicular sperm extraction (TESE) for preservation of fertility. Design Case report and literature review. Setting University teaching hospital. Pa...
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| Veröffentlicht in: | Fertility and sterility 2014-04, Vol.101 (4), p.956-959 |
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| container_title | Fertility and sterility |
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| creator | Haddad, Nicholas, M.Sc Al-Rabeeah, Khalid, M.D Onerheim, Ronald, M.D Zini, Armand, M.D |
| description | Objective To report a case of an infertile man with nonobstructive azoospermia who underwent simultaneous radical orchiectomy for testicular cancer and testicular sperm extraction (TESE) for preservation of fertility. Design Case report and literature review. Setting University teaching hospital. Patient(s) A couple being treated for infertility. Intervention(s) Radical orchiectomy with simultaneous TESE. Main Outcome Measure(s) Sperm retrieval, histologic evaluation of archived testicular pathology slides. Result(s) We retrieved 20 spermatozoa from the multiple random TESE samples obtained at radical orchiectomy. Histologic evaluation of the archived testicular pathology slides revealed that the testis contained several foci of active spermatogenesis, suggesting that a significantly greater number of spermatozoa would likely have been retrieved had a microdissection TESE been performed instead of the multiple TESEs. Conclusion(s) We propose that microdissection TESE should be considered the preferred sperm retrieval technique at the time of radical orchiectomy in men with coexistent nonobstructive azoospermia and testicular cancer. |
| doi_str_mv | 10.1016/j.fertnstert.2013.12.052 |
| format | Article |
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Case report and literature review</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Haddad, Nicholas, M.Sc ; Al-Rabeeah, Khalid, M.D ; Onerheim, Ronald, M.D ; Zini, Armand, M.D</creator><creatorcontrib>Haddad, Nicholas, M.Sc ; Al-Rabeeah, Khalid, M.D ; Onerheim, Ronald, M.D ; Zini, Armand, M.D</creatorcontrib><description>Objective To report a case of an infertile man with nonobstructive azoospermia who underwent simultaneous radical orchiectomy for testicular cancer and testicular sperm extraction (TESE) for preservation of fertility. Design Case report and literature review. Setting University teaching hospital. Patient(s) A couple being treated for infertility. Intervention(s) Radical orchiectomy with simultaneous TESE. Main Outcome Measure(s) Sperm retrieval, histologic evaluation of archived testicular pathology slides. Result(s) We retrieved 20 spermatozoa from the multiple random TESE samples obtained at radical orchiectomy. Histologic evaluation of the archived testicular pathology slides revealed that the testis contained several foci of active spermatogenesis, suggesting that a significantly greater number of spermatozoa would likely have been retrieved had a microdissection TESE been performed instead of the multiple TESEs. Conclusion(s) We propose that microdissection TESE should be considered the preferred sperm retrieval technique at the time of radical orchiectomy in men with coexistent nonobstructive azoospermia and testicular cancer.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2013.12.052</identifier><identifier>PMID: 24529661</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Cryopreservation ; Humans ; Infertility, Male - etiology ; Infertility, Male - pathology ; Infertility, Male - rehabilitation ; Internal Medicine ; Male ; Microdissection - methods ; microTESE ; nonobstructive azoospermia ; Obstetrics and Gynecology ; Orchiectomy - adverse effects ; Orchiectomy - methods ; Sperm Retrieval ; TESE ; testicular cancer ; Testicular Neoplasms - complications ; Testicular Neoplasms - surgery ; Treatment Outcome</subject><ispartof>Fertility and sterility, 2014-04, Vol.101 (4), p.956-959</ispartof><rights>2014</rights><rights>Copyright © 2014. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-eba5ee4f7a949a8cd4dc73fae0bc246399eb2d48b64629063ebaa3889e908a1d3</citedby><cites>FETCH-LOGICAL-c479t-eba5ee4f7a949a8cd4dc73fae0bc246399eb2d48b64629063ebaa3889e908a1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2013.12.052$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24529661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haddad, Nicholas, M.Sc</creatorcontrib><creatorcontrib>Al-Rabeeah, Khalid, M.D</creatorcontrib><creatorcontrib>Onerheim, Ronald, M.D</creatorcontrib><creatorcontrib>Zini, Armand, M.D</creatorcontrib><title>Is ex vivo microdissection testicular sperm extraction indicated for infertile men undergoing radical orchiectomy for testicular cancer? Case report and literature review</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To report a case of an infertile man with nonobstructive azoospermia who underwent simultaneous radical orchiectomy for testicular cancer and testicular sperm extraction (TESE) for preservation of fertility. Design Case report and literature review. Setting University teaching hospital. Patient(s) A couple being treated for infertility. Intervention(s) Radical orchiectomy with simultaneous TESE. Main Outcome Measure(s) Sperm retrieval, histologic evaluation of archived testicular pathology slides. Result(s) We retrieved 20 spermatozoa from the multiple random TESE samples obtained at radical orchiectomy. Histologic evaluation of the archived testicular pathology slides revealed that the testis contained several foci of active spermatogenesis, suggesting that a significantly greater number of spermatozoa would likely have been retrieved had a microdissection TESE been performed instead of the multiple TESEs. Conclusion(s) We propose that microdissection TESE should be considered the preferred sperm retrieval technique at the time of radical orchiectomy in men with coexistent nonobstructive azoospermia and testicular cancer.</description><subject>Adult</subject><subject>Cryopreservation</subject><subject>Humans</subject><subject>Infertility, Male - etiology</subject><subject>Infertility, Male - pathology</subject><subject>Infertility, Male - rehabilitation</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Microdissection - methods</subject><subject>microTESE</subject><subject>nonobstructive azoospermia</subject><subject>Obstetrics and Gynecology</subject><subject>Orchiectomy - adverse effects</subject><subject>Orchiectomy - methods</subject><subject>Sperm Retrieval</subject><subject>TESE</subject><subject>testicular cancer</subject><subject>Testicular Neoplasms - complications</subject><subject>Testicular Neoplasms - surgery</subject><subject>Treatment Outcome</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsuOFCEUJUbj9Iz-gmHppkseVTRsNNrxMckkLtQ1oeDWSFsFLVCt_Tfu_Qu_bCh7fMSVGwhwzrn3ngNCmJKGEiqe7JoBUgm51LVhhPKGsoZ07A5a0a4T6050_C5aEUK7NWGSnaHznHeEEEE37D46Y23HlBB0hb5fZgxff3w7-EPEk7cpOp8z2OJjwAVy8XYeTcJ5D2mqyJLM6c0H560p4PAQUz0tDfkR8AQBz8FBuo4-XONkFtiIY7IffZWN0_En4S9pa4KF9AxvTQacYB9TwSY4PPo6nilzWm4PHr48QPcGM2Z4eLtfoA-vXr7fvllfvX19uX1-tbbtRpU19KYDaIeNUa0y0rrW2Q0fDJDeslZwpaBnrpW9aAVTRPBKMFxKBYpIQx2_QI9PuvsUP8-1UT35bGEcTYA4Z007SiWjUokKlSdoNS7nBIPeJz-ZdNSU6CUqvdN_otJLVJoyXaOq1Ee3VeZ-Aveb-CubCnhxAkCdtc6fdLYeqlfOp-qkdtH_T5Wn_4jY0Yclkk9whLyLcwrVS011rgT9bvkyy4-hnPBWSsZvABDqxpk</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Haddad, Nicholas, M.Sc</creator><creator>Al-Rabeeah, Khalid, M.D</creator><creator>Onerheim, Ronald, M.D</creator><creator>Zini, Armand, M.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Is ex vivo microdissection testicular sperm extraction indicated for infertile men undergoing radical orchiectomy for testicular cancer? Case report and literature review</title><author>Haddad, Nicholas, M.Sc ; Al-Rabeeah, Khalid, M.D ; Onerheim, Ronald, M.D ; Zini, Armand, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-eba5ee4f7a949a8cd4dc73fae0bc246399eb2d48b64629063ebaa3889e908a1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Cryopreservation</topic><topic>Humans</topic><topic>Infertility, Male - etiology</topic><topic>Infertility, Male - pathology</topic><topic>Infertility, Male - rehabilitation</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Microdissection - methods</topic><topic>microTESE</topic><topic>nonobstructive azoospermia</topic><topic>Obstetrics and Gynecology</topic><topic>Orchiectomy - adverse effects</topic><topic>Orchiectomy - methods</topic><topic>Sperm Retrieval</topic><topic>TESE</topic><topic>testicular cancer</topic><topic>Testicular Neoplasms - complications</topic><topic>Testicular Neoplasms - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haddad, Nicholas, M.Sc</creatorcontrib><creatorcontrib>Al-Rabeeah, Khalid, M.D</creatorcontrib><creatorcontrib>Onerheim, Ronald, M.D</creatorcontrib><creatorcontrib>Zini, Armand, M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haddad, Nicholas, M.Sc</au><au>Al-Rabeeah, Khalid, M.D</au><au>Onerheim, Ronald, M.D</au><au>Zini, Armand, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is ex vivo microdissection testicular sperm extraction indicated for infertile men undergoing radical orchiectomy for testicular cancer? Case report and literature review</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>101</volume><issue>4</issue><spage>956</spage><epage>959</epage><pages>956-959</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>Objective To report a case of an infertile man with nonobstructive azoospermia who underwent simultaneous radical orchiectomy for testicular cancer and testicular sperm extraction (TESE) for preservation of fertility. Design Case report and literature review. Setting University teaching hospital. Patient(s) A couple being treated for infertility. Intervention(s) Radical orchiectomy with simultaneous TESE. Main Outcome Measure(s) Sperm retrieval, histologic evaluation of archived testicular pathology slides. Result(s) We retrieved 20 spermatozoa from the multiple random TESE samples obtained at radical orchiectomy. Histologic evaluation of the archived testicular pathology slides revealed that the testis contained several foci of active spermatogenesis, suggesting that a significantly greater number of spermatozoa would likely have been retrieved had a microdissection TESE been performed instead of the multiple TESEs. Conclusion(s) We propose that microdissection TESE should be considered the preferred sperm retrieval technique at the time of radical orchiectomy in men with coexistent nonobstructive azoospermia and testicular cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24529661</pmid><doi>10.1016/j.fertnstert.2013.12.052</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Cryopreservation Humans Infertility, Male - etiology Infertility, Male - pathology Infertility, Male - rehabilitation Internal Medicine Male Microdissection - methods microTESE nonobstructive azoospermia Obstetrics and Gynecology Orchiectomy - adverse effects Orchiectomy - methods Sperm Retrieval TESE testicular cancer Testicular Neoplasms - complications Testicular Neoplasms - surgery Treatment Outcome |
| title | Is ex vivo microdissection testicular sperm extraction indicated for infertile men undergoing radical orchiectomy for testicular cancer? Case report and literature review |
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