Cadmium induced changes in cell organelles: an ultrastructural study using cadmium sensitive and resistant muntjac fibroblast cell lines
A detailed electron microscopy study of cadmium sensitive and resistant muntjac fibroblast cell lines has identified a wide range of intracellular damage following exposure to cadmium. Damaged organelles included cell membrane, mitochondria, Golgi cisternae and tubular network, chromatin, nucleoli,...
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| Veröffentlicht in: | Archives of toxicology 1988, Vol.62 (2-3), p.133-145 |
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| container_issue | 2-3 |
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| container_title | Archives of toxicology |
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| creator | ORD, M. J BOUFFLER, S. D CHIBBER, R |
| description | A detailed electron microscopy study of cadmium sensitive and resistant muntjac fibroblast cell lines has identified a wide range of intracellular damage following exposure to cadmium. Damaged organelles included cell membrane, mitochondria, Golgi cisternae and tubular network, chromatin, nucleoli, microfilaments and ribosomes. Although cell membrane damage was generally the earliest indication of adverse cadmium action, particularly with continuous cadmium exposures, cells could tolerate extensive membrane loss. Mitochondrial distortion and some damage to Golgi was also tolerated. The turning point at which cadmium became lethal was generally marked by a cascade of events which included damage to both nuclear and cytoplasmic components. These results for fibroblasts are discussed and compared with damage reported in other types of cells. |
| doi_str_mv | 10.1007/BF00570131 |
| format | Article |
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These results for fibroblasts are discussed and compared with damage reported in other types of cells.</description><identifier>ISSN: 0340-5761</identifier><identifier>EISSN: 1432-0738</identifier><identifier>DOI: 10.1007/BF00570131</identifier><identifier>PMID: 3196148</identifier><identifier>CODEN: ARTODN</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Cadmium - toxicity ; Cell Line ; Cell Membrane - drug effects ; Cell Nucleus - drug effects ; Chemical and industrial products toxicology. 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J</creatorcontrib><creatorcontrib>BOUFFLER, S. D</creatorcontrib><creatorcontrib>CHIBBER, R</creatorcontrib><title>Cadmium induced changes in cell organelles: an ultrastructural study using cadmium sensitive and resistant muntjac fibroblast cell lines</title><title>Archives of toxicology</title><addtitle>Arch Toxicol</addtitle><description>A detailed electron microscopy study of cadmium sensitive and resistant muntjac fibroblast cell lines has identified a wide range of intracellular damage following exposure to cadmium. Damaged organelles included cell membrane, mitochondria, Golgi cisternae and tubular network, chromatin, nucleoli, microfilaments and ribosomes. Although cell membrane damage was generally the earliest indication of adverse cadmium action, particularly with continuous cadmium exposures, cells could tolerate extensive membrane loss. Mitochondrial distortion and some damage to Golgi was also tolerated. The turning point at which cadmium became lethal was generally marked by a cascade of events which included damage to both nuclear and cytoplasmic components. These results for fibroblasts are discussed and compared with damage reported in other types of cells.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cadmium - toxicity</subject><subject>Cell Line</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Nucleus - drug effects</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cytoskeleton - drug effects</subject><subject>Deer</subject><subject>Fibroblasts</subject><subject>Golgi Apparatus - drug effects</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Mitochondria - drug effects</subject><subject>Organelles - drug effects</subject><subject>Ribosomes - drug effects</subject><subject>Toxicology</subject><issn>0340-5761</issn><issn>1432-0738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFv1TAMxyPENB6DC3ekHBAHpG5x09e03OCJAdIkLuNcpY77yNSmI06Q9g342GR61TjZln_-2_4L8QbUJShlrj5fK7U3CjQ8EztodF0po7vnYqd0o6q9aeGFeMl8pxTUXa_PxbmGvoWm24m_B-sWnxfpg8tITuIvG47EpZZI8yzXeLShJMQfpQ0yzylaTjFjytHOklN2DzKzD0eJmxRTYJ_8HyoDTkZiz8mGJJcc0p1FOfkxruNcZE4rZh-IX4mzyc5Mr7d4IX5ef7k9fKtufnz9fvh0U6HumlTpHhQRTXXtnKN-whEcIrU1QG9U66YaNXZoidC2U6PqDlRflwJbN4621Rfi_Un3Pq6_M3EaFs-PZ5Qv18wD7AFM36kCfjiBGFfmSNNwH_1i48MAani0ffhve4Hfbqp5XMg9oZvPpf9u61tGO0_RBvT8hBkwXd8a_Q8FL44c</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>ORD, M. 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D ; CHIBBER, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-3910eeef22ddde9fcb1dcce62119706df2c3c8caeeca6f40281092ecac6dbba63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cadmium - toxicity</topic><topic>Cell Line</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Nucleus - drug effects</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cytoskeleton - drug effects</topic><topic>Deer</topic><topic>Fibroblasts</topic><topic>Golgi Apparatus - drug effects</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Mitochondria - drug effects</topic><topic>Organelles - drug effects</topic><topic>Ribosomes - drug effects</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ORD, M. J</creatorcontrib><creatorcontrib>BOUFFLER, S. D</creatorcontrib><creatorcontrib>CHIBBER, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Archives of toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ORD, M. J</au><au>BOUFFLER, S. D</au><au>CHIBBER, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cadmium induced changes in cell organelles: an ultrastructural study using cadmium sensitive and resistant muntjac fibroblast cell lines</atitle><jtitle>Archives of toxicology</jtitle><addtitle>Arch Toxicol</addtitle><date>1988</date><risdate>1988</risdate><volume>62</volume><issue>2-3</issue><spage>133</spage><epage>145</epage><pages>133-145</pages><issn>0340-5761</issn><eissn>1432-0738</eissn><coden>ARTODN</coden><abstract>A detailed electron microscopy study of cadmium sensitive and resistant muntjac fibroblast cell lines has identified a wide range of intracellular damage following exposure to cadmium. Damaged organelles included cell membrane, mitochondria, Golgi cisternae and tubular network, chromatin, nucleoli, microfilaments and ribosomes. 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| identifier | ISSN: 0340-5761 |
| ispartof | Archives of toxicology, 1988, Vol.62 (2-3), p.133-145 |
| issn | 0340-5761 1432-0738 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Cadmium - toxicity Cell Line Cell Membrane - drug effects Cell Nucleus - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Cytoskeleton - drug effects Deer Fibroblasts Golgi Apparatus - drug effects Medical sciences Metals and various inorganic compounds Mitochondria - drug effects Organelles - drug effects Ribosomes - drug effects Toxicology |
| title | Cadmium induced changes in cell organelles: an ultrastructural study using cadmium sensitive and resistant muntjac fibroblast cell lines |
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