Nickel antigen induces IL-2 secretion and IL-2 receptor expression mainly on CD4 super(+) T cells, but no measurable gamma interferon secretion in peripheral blood mononuclear cell cultures in delayed type hypersensitivity to nickel

Nickel antigen induces IL-2 secretion and IL-2 receptor expression mainly on CD4 super(+) T cells, but no measurable gamma interferon secretion in peripheral blood mononuclear cell cultures in delayed type hypersensitivity to nickel

Nickel sulphate antigen-induced peripheral blood lymphocyte activation in vitro was characterized by lymphokine measurement (IL-2, IFN- gamma ) and phenotyping of the IL-2 responsive cells. Mononuclear cells from nickel-sensitive patients synthesized more DNA, produced more IL-2 and had more IL-2 re...

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Veröffentlicht in:Clinical and experimental immunology 1988-01, Vol.74 (3), p.387-391
Hauptverfasser: Karttunen, R, Silvennoinen-Kassinen, S, Juutinen, K, Andersson, G, Ekre, H-PT, Karvonen, J
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container_end_page 391
container_issue 3
container_start_page 387
container_title Clinical and experimental immunology
container_volume 74
creator Karttunen, R
Silvennoinen-Kassinen, S
Juutinen, K
Andersson, G
Ekre, H-PT
Karvonen, J
description Nickel sulphate antigen-induced peripheral blood lymphocyte activation in vitro was characterized by lymphokine measurement (IL-2, IFN- gamma ) and phenotyping of the IL-2 responsive cells. Mononuclear cells from nickel-sensitive patients synthesized more DNA, produced more IL-2 and had more IL-2 receptor positive cells in response to nickel than did those of the control subjects. On the other hand no IFN- gamma was detectable in the nickel supernatants, while PPD, used as the control antigen, induced pronounced quantities of IFN- gamma with an equal amount of DNA synthesis. In conclusion, nickel-induced peripheral blood mononuclear cell activation in vitro differs from microbial antigen-induced activation with respect to its modest or non-existent IFN- gamma response.
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title Nickel antigen induces IL-2 secretion and IL-2 receptor expression mainly on CD4 super(+) T cells, but no measurable gamma interferon secretion in peripheral blood mononuclear cell cultures in delayed type hypersensitivity to nickel
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