CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer
Carcinoembryonic antigen-related cell adhesion molecule 6 （CEACAM6） shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis. Here, we reported that CEACAM6 was up-regulated in gastric cancer （GC） c...
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| Veröffentlicht in: | Acta biochimica et biophysica Sinica 2014-04, Vol.46 (4), p.283-290 |
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| container_title | Acta biochimica et biophysica Sinica |
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| creator | Zhang, Yunqiang Zang, Mingde Li, Jianfang Ji, Jun Zhang, Jianian Liu, Xiaolei Qu, Ying Su, Liping Li, Chen Yu, Yinyan Zhu, Zhenggang Liu, Bingya Yan, Min |
| description | Carcinoembryonic antigen-related cell adhesion molecule 6 （CEACAM6） shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis. Here, we reported that CEACAM6 was up-regulated in gastric cancer （GC） cell lines and tumor tissues. Overexpression of CEACAM6 in MKN-45 and SGC-7901 GC cells promoted migration and invasion in vitro and metastasis in athymic mice, whereas migration and invasion of MKN-28 and SNU-16 GC cells were suppressed by knockdown of CEACAM6. We also observed that steroid receptor coactivator （C-SRC） phosphorylation was increased when CEACAM6 was over-expressed in SGC-7901 cells. Taken together, these results suggested that CEACAM6 functions as an oncoprotein in GC and may be an important metastatic biomarker and therapeutic target. |
| doi_str_mv | 10.1093/abbs/gmu001 |
| format | Article |
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Here, we reported that CEACAM6 was up-regulated in gastric cancer （GC） cell lines and tumor tissues. Overexpression of CEACAM6 in MKN-45 and SGC-7901 GC cells promoted migration and invasion in vitro and metastasis in athymic mice, whereas migration and invasion of MKN-28 and SNU-16 GC cells were suppressed by knockdown of CEACAM6. We also observed that steroid receptor coactivator （C-SRC） phosphorylation was increased when CEACAM6 was over-expressed in SGC-7901 cells. Taken together, these results suggested that CEACAM6 functions as an oncoprotein in GC and may be an important metastatic biomarker and therapeutic target.</description><identifier>ISSN: 1672-9145</identifier><identifier>EISSN: 1745-7270</identifier><identifier>DOI: 10.1093/abbs/gmu001</identifier><identifier>PMID: 24492534</identifier><language>eng</language><publisher>China</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Animals ; Antigens, CD - genetics ; Antigens, CD - physiology ; Base Sequence ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - physiology ; Female ; Gene Knockdown Techniques ; GPI-Linked Proteins - genetics ; GPI-Linked Proteins - physiology ; Humans ; Male ; Mice ; Middle Aged ; Neoplasm Invasiveness - physiopathology ; Neoplasm Metastasis - physiopathology ; Phosphorylation ; RNA, Small Interfering ; Stomach Neoplasms - pathology ; Up-Regulation ; 侵袭 ; 生物标志物 ; 癌胚抗原 ; 细胞粘附分子 ; 肿瘤组织 ; 胃癌细胞 ; 迁移 ; 过度表达</subject><ispartof>Acta biochimica et biophysica Sinica, 2014-04, Vol.46 (4), p.283-290</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-c45b574f77c01a4097b610e1fc0fd47b3fd5ca982df57c8efaedcdd28f977e6c3</citedby><cites>FETCH-LOGICAL-c418t-c45b574f77c01a4097b610e1fc0fd47b3fd5ca982df57c8efaedcdd28f977e6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/90160X/90160X.jpg</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24492534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yunqiang</creatorcontrib><creatorcontrib>Zang, Mingde</creatorcontrib><creatorcontrib>Li, Jianfang</creatorcontrib><creatorcontrib>Ji, Jun</creatorcontrib><creatorcontrib>Zhang, Jianian</creatorcontrib><creatorcontrib>Liu, Xiaolei</creatorcontrib><creatorcontrib>Qu, Ying</creatorcontrib><creatorcontrib>Su, Liping</creatorcontrib><creatorcontrib>Li, Chen</creatorcontrib><creatorcontrib>Yu, Yinyan</creatorcontrib><creatorcontrib>Zhu, Zhenggang</creatorcontrib><creatorcontrib>Liu, Bingya</creatorcontrib><creatorcontrib>Yan, Min</creatorcontrib><title>CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer</title><title>Acta biochimica et biophysica Sinica</title><addtitle>Acta Biochimica et Biophysica Sinica</addtitle><description>Carcinoembryonic antigen-related cell adhesion molecule 6 （CEACAM6） shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis. Here, we reported that CEACAM6 was up-regulated in gastric cancer （GC） cell lines and tumor tissues. Overexpression of CEACAM6 in MKN-45 and SGC-7901 GC cells promoted migration and invasion in vitro and metastasis in athymic mice, whereas migration and invasion of MKN-28 and SNU-16 GC cells were suppressed by knockdown of CEACAM6. We also observed that steroid receptor coactivator （C-SRC） phosphorylation was increased when CEACAM6 was over-expressed in SGC-7901 cells. Taken together, these results suggested that CEACAM6 functions as an oncoprotein in GC and may be an important metastatic biomarker and therapeutic target.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - physiology</subject><subject>Base Sequence</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>Female</subject><subject>Gene Knockdown Techniques</subject><subject>GPI-Linked Proteins - genetics</subject><subject>GPI-Linked Proteins - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - physiopathology</subject><subject>Neoplasm Metastasis - physiopathology</subject><subject>Phosphorylation</subject><subject>RNA, Small Interfering</subject><subject>Stomach Neoplasms - pathology</subject><subject>Up-Regulation</subject><subject>侵袭</subject><subject>生物标志物</subject><subject>癌胚抗原</subject><subject>细胞粘附分子</subject><subject>肿瘤组织</subject><subject>胃癌细胞</subject><subject>迁移</subject><subject>过度表达</subject><issn>1672-9145</issn><issn>1745-7270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kN1LwzAUxYMoTqdPvkt8E7QuaZOmeRxlfsDEF30uaT5qZEm3pBX8783cHFzuPXB_HA4HgCuMHjDixUy0bZx1bkQIH4EzzAjNWM7QcdIlyzOOCZ2A8xi_ECrKEqNTMMkJ4TktyBlY1ot5PX8t4Tr0rh90hMPo-gCd7YIYbO_vofXfIv4p4RV0ehAxjY3pAbukg5VQCi91uAAnRqyivtzfKfh4XLzXz9ny7emlni8zSXA1pE1byohhTCIsCOKsTbE0NhIZRVhbGEWl4FWuDGWy0kZoJZXKK8MZ06UspuB255tCb0Ydh8bZKPVqJbzux9hginHBecloQu92qAx9jEGbZh2sE-GnwajZ1tds62t29SX6em88tk6rA_vfVwJu9nafve821ncHhvAKU4RI8QvCU3f7</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Zhang, Yunqiang</creator><creator>Zang, Mingde</creator><creator>Li, Jianfang</creator><creator>Ji, Jun</creator><creator>Zhang, Jianian</creator><creator>Liu, Xiaolei</creator><creator>Qu, Ying</creator><creator>Su, Liping</creator><creator>Li, Chen</creator><creator>Yu, Yinyan</creator><creator>Zhu, Zhenggang</creator><creator>Liu, Bingya</creator><creator>Yan, Min</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer</title><author>Zhang, Yunqiang ; Zang, Mingde ; Li, Jianfang ; Ji, Jun ; Zhang, Jianian ; Liu, Xiaolei ; Qu, Ying ; Su, Liping ; Li, Chen ; Yu, Yinyan ; Zhu, Zhenggang ; Liu, Bingya ; Yan, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-c45b574f77c01a4097b610e1fc0fd47b3fd5ca982df57c8efaedcdd28f977e6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - physiology</topic><topic>Base Sequence</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Adhesion Molecules - physiology</topic><topic>Female</topic><topic>Gene Knockdown Techniques</topic><topic>GPI-Linked Proteins - genetics</topic><topic>GPI-Linked Proteins - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - physiopathology</topic><topic>Neoplasm Metastasis - physiopathology</topic><topic>Phosphorylation</topic><topic>RNA, Small Interfering</topic><topic>Stomach Neoplasms - pathology</topic><topic>Up-Regulation</topic><topic>侵袭</topic><topic>生物标志物</topic><topic>癌胚抗原</topic><topic>细胞粘附分子</topic><topic>肿瘤组织</topic><topic>胃癌细胞</topic><topic>迁移</topic><topic>过度表达</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yunqiang</creatorcontrib><creatorcontrib>Zang, Mingde</creatorcontrib><creatorcontrib>Li, Jianfang</creatorcontrib><creatorcontrib>Ji, Jun</creatorcontrib><creatorcontrib>Zhang, Jianian</creatorcontrib><creatorcontrib>Liu, Xiaolei</creatorcontrib><creatorcontrib>Qu, Ying</creatorcontrib><creatorcontrib>Su, Liping</creatorcontrib><creatorcontrib>Li, Chen</creatorcontrib><creatorcontrib>Yu, Yinyan</creatorcontrib><creatorcontrib>Zhu, Zhenggang</creatorcontrib><creatorcontrib>Liu, Bingya</creatorcontrib><creatorcontrib>Yan, Min</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biochimica et biophysica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yunqiang</au><au>Zang, Mingde</au><au>Li, Jianfang</au><au>Ji, Jun</au><au>Zhang, Jianian</au><au>Liu, Xiaolei</au><au>Qu, Ying</au><au>Su, Liping</au><au>Li, Chen</au><au>Yu, Yinyan</au><au>Zhu, Zhenggang</au><au>Liu, Bingya</au><au>Yan, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer</atitle><jtitle>Acta biochimica et biophysica Sinica</jtitle><addtitle>Acta Biochimica et Biophysica Sinica</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>46</volume><issue>4</issue><spage>283</spage><epage>290</epage><pages>283-290</pages><issn>1672-9145</issn><eissn>1745-7270</eissn><abstract>Carcinoembryonic antigen-related cell adhesion molecule 6 （CEACAM6） shows increased expression in a wide variety of human cancers, and its over-expression is associated with enhanced migration, invasion, and in vivo metastasis. Here, we reported that CEACAM6 was up-regulated in gastric cancer （GC） cell lines and tumor tissues. Overexpression of CEACAM6 in MKN-45 and SGC-7901 GC cells promoted migration and invasion in vitro and metastasis in athymic mice, whereas migration and invasion of MKN-28 and SNU-16 GC cells were suppressed by knockdown of CEACAM6. We also observed that steroid receptor coactivator （C-SRC） phosphorylation was increased when CEACAM6 was over-expressed in SGC-7901 cells. Taken together, these results suggested that CEACAM6 functions as an oncoprotein in GC and may be an important metastatic biomarker and therapeutic target.</abstract><cop>China</cop><pmid>24492534</pmid><doi>10.1093/abbs/gmu001</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Animals Antigens, CD - genetics Antigens, CD - physiology Base Sequence Cell Adhesion Molecules - genetics Cell Adhesion Molecules - physiology Female Gene Knockdown Techniques GPI-Linked Proteins - genetics GPI-Linked Proteins - physiology Humans Male Mice Middle Aged Neoplasm Invasiveness - physiopathology Neoplasm Metastasis - physiopathology Phosphorylation RNA, Small Interfering Stomach Neoplasms - pathology Up-Regulation 侵袭 生物标志物 癌胚抗原 细胞粘附分子 肿瘤组织 胃癌细胞 迁移 过度表达 |
| title | CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer |
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