Induction of apoptosis by total flavonoids from Scutellaria barbata D. Don in human hepatocarcinoma MHCC97-H cells via the mitochondrial pathway

Scutellaria barbata D. Don, a traditional Chinese medicine, reportedly possesses antitumor activity against a variety of tumors. In the present study, we investigated the cytotoxic effect of total flavonoids from S. barbata (TF-SB) on human hepatocarcinoma cells and the underlying molecular mechanis...

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Veröffentlicht in:	Tumor biology 2014-03, Vol.35 (3), p.2549-2559
Hauptverfasser:	Gao, Jie, Lu, Wang-Feng, Dai, Zhi-Jun, Lin, Shuai, Zhao, Yang, Li, Sha, Zhao, Nuan-Nuan, Wang, Xi-Jing, Kang, Hua-Feng, Ma, Xiao-Bin, Zhang, Wang-Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Survival - drug effects Chinese medicine DNA Fragmentation Flavonoids - pharmacology Flow Cytometry Humans Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Membrane Potential, Mitochondrial - drug effects Membrane Potential, Mitochondrial - physiology Mitochondria Mitochondria - drug effects Mitochondria - metabolism Plant Extracts - pharmacology Research Article Reverse Transcriptase Polymerase Chain Reaction
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