Is Osteopontin Involved in Cutaneous Fibroblast Activation? Its Hypothetical Role in Scleroderma Pathogenesis

Osteopontin (OPN) is an extracellular matrix protein implicated in bone remodeling, but it presents also pro-inflammatory and pro-fibrotic properties. OPN expression also occurs upon exposure of cells to classical mediators of acute inflammation such as tumor necrosis growth factor alpha (TNF-α) and...

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Veröffentlicht in:	International journal of immunopathology and pharmacology 2014-01, Vol.27 (1), p.97-102
Hauptverfasser:	Corallo, C., Volpi, N., Franci, D., Montella, A., Biagioli, M., Mariotti, G., D'Onofrio, F., Gonnelli, S., Nuti, R., Giordano, N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Bleomycin - pharmacology Blotting, Western Case-Control Studies Cell Differentiation Cells, Cultured Endothelin-1 - pharmacology Enzyme-Linked Immunosorbent Assay Female Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Humans Immunohistochemistry Middle Aged Osteopontin - blood Osteopontin - metabolism Scleroderma, Systemic - blood Scleroderma, Systemic - etiology Scleroderma, Systemic - metabolism Scleroderma, Systemic - pathology Transforming Growth Factor beta - pharmacology
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