Is empiric therapy with fluconazole appropriate for esophageal candidiasis?
We studied the prevalence of fluconazole resistance in esophageal candidiasis. Patients with suspected esophageal candidiasis during gastroscopy underwent culture of white plaques. Minimum inhibitory concentration (MIC) >64 μg/mL of fluconazole for Candida was indicative of resistance. Sensitivit...
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| Veröffentlicht in: | Indian journal of gastroenterology 2014-03, Vol.33 (2), p.165-168 |
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| container_title | Indian journal of gastroenterology |
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| creator | Sajith, Kattiparambil Gangadharan Dutta, Amit Kumar Sahni, Rani Diana Esakimuthu, Saritha Chacko, Ashok |
| description | We studied the prevalence of fluconazole resistance in esophageal candidiasis. Patients with suspected esophageal candidiasis during gastroscopy underwent culture of white plaques. Minimum inhibitory concentration (MIC) >64 μg/mL of fluconazole for Candida was indicative of resistance. Sensitivity of itraconazole was tested in a subset of resistant strains. Sixty-five patients were included. Mean (SD) age was 50.03 (13.5) years and 67.7 % were males. Predisposing factors for candidiasis were found in 42 (64.6 %) patients.
C. albicans
was identified in 64 (97.4 %) patients and
C. glabrata
in one patient. Fluconazole resistance was seen in 38 (59.4 %) patients with
C. albicans
and also in the one patient with
C. glabrata
. All the fluconazole resistant isolates of
C. albicans
had MIC >128 μg/mL suggesting very high resistance. Twelve patients with fluconazole resistance had itraconazole resistance as well. The study shows a high rate of fluconazole resistance in patients with esophageal candidiasis. |
| doi_str_mv | 10.1007/s12664-013-0439-6 |
| format | Article |
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C. albicans
was identified in 64 (97.4 %) patients and
C. glabrata
in one patient. Fluconazole resistance was seen in 38 (59.4 %) patients with
C. albicans
and also in the one patient with
C. glabrata
. All the fluconazole resistant isolates of
C. albicans
had MIC >128 μg/mL suggesting very high resistance. Twelve patients with fluconazole resistance had itraconazole resistance as well. The study shows a high rate of fluconazole resistance in patients with esophageal candidiasis.</description><identifier>ISSN: 0254-8860</identifier><identifier>EISSN: 0975-0711</identifier><identifier>DOI: 10.1007/s12664-013-0439-6</identifier><identifier>PMID: 24424852</identifier><language>eng</language><publisher>India: Springer India</publisher><subject>Adult ; Candida albicans - drug effects ; Candida albicans - isolation & purification ; Candida glabrata - drug effects ; Candida glabrata - isolation & purification ; Candidiasis - drug therapy ; Candidiasis - microbiology ; Drug Resistance, Fungal ; Esophageal Diseases - drug therapy ; Esophageal Diseases - microbiology ; Female ; Fluconazole - pharmacology ; Fluconazole - therapeutic use ; Gastroenterology ; Hepatology ; Humans ; Itraconazole - pharmacology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Short Report</subject><ispartof>Indian journal of gastroenterology, 2014-03, Vol.33 (2), p.165-168</ispartof><rights>Indian Society of Gastroenterology 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c296t-e33207be55b7f46d249bcb31001175069ea61ad40f000f140faaf1d9a604abe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12664-013-0439-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12664-013-0439-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24424852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sajith, Kattiparambil Gangadharan</creatorcontrib><creatorcontrib>Dutta, Amit Kumar</creatorcontrib><creatorcontrib>Sahni, Rani Diana</creatorcontrib><creatorcontrib>Esakimuthu, Saritha</creatorcontrib><creatorcontrib>Chacko, Ashok</creatorcontrib><title>Is empiric therapy with fluconazole appropriate for esophageal candidiasis?</title><title>Indian journal of gastroenterology</title><addtitle>Indian J Gastroenterol</addtitle><addtitle>Indian J Gastroenterol</addtitle><description>We studied the prevalence of fluconazole resistance in esophageal candidiasis. Patients with suspected esophageal candidiasis during gastroscopy underwent culture of white plaques. Minimum inhibitory concentration (MIC) >64 μg/mL of fluconazole for Candida was indicative of resistance. Sensitivity of itraconazole was tested in a subset of resistant strains. Sixty-five patients were included. Mean (SD) age was 50.03 (13.5) years and 67.7 % were males. Predisposing factors for candidiasis were found in 42 (64.6 %) patients.
C. albicans
was identified in 64 (97.4 %) patients and
C. glabrata
in one patient. Fluconazole resistance was seen in 38 (59.4 %) patients with
C. albicans
and also in the one patient with
C. glabrata
. All the fluconazole resistant isolates of
C. albicans
had MIC >128 μg/mL suggesting very high resistance. Twelve patients with fluconazole resistance had itraconazole resistance as well. The study shows a high rate of fluconazole resistance in patients with esophageal candidiasis.</description><subject>Adult</subject><subject>Candida albicans - drug effects</subject><subject>Candida albicans - isolation & purification</subject><subject>Candida glabrata - drug effects</subject><subject>Candida glabrata - isolation & purification</subject><subject>Candidiasis - drug therapy</subject><subject>Candidiasis - microbiology</subject><subject>Drug Resistance, Fungal</subject><subject>Esophageal Diseases - drug therapy</subject><subject>Esophageal Diseases - microbiology</subject><subject>Female</subject><subject>Fluconazole - pharmacology</subject><subject>Fluconazole - therapeutic use</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Itraconazole - pharmacology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Short Report</subject><issn>0254-8860</issn><issn>0975-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEYmPwA7igHLkUnDRN1xNCE19iEhc4R27rbp36RdIKjV9Pqg6OnGzLr1_5fRi7FHAjAOJbJ6TWKgARBqDCJNBHbA5JHAUQC3HsexmpYLnUMGNnzu1gnJPwlM2kUlItIzlnry-OU92Vtsx4vyWL3Z5_lf2WF9WQtQ1-txVx7DrbdrbEnnjRWk6u7ba4Iax4hk1e5iW60t2ds5MCK0cXh7pgH48P76vnYP329LK6XweZTHQfUBhKiFOKojQulM6lStIsDX0iIeIIdEKoBeYKCgAohK-IhcgT1KAwJR0u2PXk67_6HMj1pi5dRlWFDbWDMyISIwC5BC8VkzSzrXOWCuNj1Gj3RoAZGZqJofEMzcjQjPZXB_shrSn_u_iF5gVyEji_ajZkza4dbOMj_-P6A2SHfGs</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Sajith, Kattiparambil Gangadharan</creator><creator>Dutta, Amit Kumar</creator><creator>Sahni, Rani Diana</creator><creator>Esakimuthu, Saritha</creator><creator>Chacko, Ashok</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Is empiric therapy with fluconazole appropriate for esophageal candidiasis?</title><author>Sajith, Kattiparambil Gangadharan ; Dutta, Amit Kumar ; Sahni, Rani Diana ; Esakimuthu, Saritha ; Chacko, Ashok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-e33207be55b7f46d249bcb31001175069ea61ad40f000f140faaf1d9a604abe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Candida albicans - drug effects</topic><topic>Candida albicans - isolation & purification</topic><topic>Candida glabrata - drug effects</topic><topic>Candida glabrata - isolation & purification</topic><topic>Candidiasis - drug therapy</topic><topic>Candidiasis - microbiology</topic><topic>Drug Resistance, Fungal</topic><topic>Esophageal Diseases - drug therapy</topic><topic>Esophageal Diseases - microbiology</topic><topic>Female</topic><topic>Fluconazole - pharmacology</topic><topic>Fluconazole - therapeutic use</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Itraconazole - pharmacology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Short Report</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sajith, Kattiparambil Gangadharan</creatorcontrib><creatorcontrib>Dutta, Amit Kumar</creatorcontrib><creatorcontrib>Sahni, Rani Diana</creatorcontrib><creatorcontrib>Esakimuthu, Saritha</creatorcontrib><creatorcontrib>Chacko, Ashok</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sajith, Kattiparambil Gangadharan</au><au>Dutta, Amit Kumar</au><au>Sahni, Rani Diana</au><au>Esakimuthu, Saritha</au><au>Chacko, Ashok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is empiric therapy with fluconazole appropriate for esophageal candidiasis?</atitle><jtitle>Indian journal of gastroenterology</jtitle><stitle>Indian J Gastroenterol</stitle><addtitle>Indian J Gastroenterol</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>33</volume><issue>2</issue><spage>165</spage><epage>168</epage><pages>165-168</pages><issn>0254-8860</issn><eissn>0975-0711</eissn><abstract>We studied the prevalence of fluconazole resistance in esophageal candidiasis. Patients with suspected esophageal candidiasis during gastroscopy underwent culture of white plaques. Minimum inhibitory concentration (MIC) >64 μg/mL of fluconazole for Candida was indicative of resistance. Sensitivity of itraconazole was tested in a subset of resistant strains. Sixty-five patients were included. Mean (SD) age was 50.03 (13.5) years and 67.7 % were males. Predisposing factors for candidiasis were found in 42 (64.6 %) patients.
C. albicans
was identified in 64 (97.4 %) patients and
C. glabrata
in one patient. Fluconazole resistance was seen in 38 (59.4 %) patients with
C. albicans
and also in the one patient with
C. glabrata
. All the fluconazole resistant isolates of
C. albicans
had MIC >128 μg/mL suggesting very high resistance. Twelve patients with fluconazole resistance had itraconazole resistance as well. The study shows a high rate of fluconazole resistance in patients with esophageal candidiasis.</abstract><cop>India</cop><pub>Springer India</pub><pmid>24424852</pmid><doi>10.1007/s12664-013-0439-6</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Candida albicans - drug effects Candida albicans - isolation & purification Candida glabrata - drug effects Candida glabrata - isolation & purification Candidiasis - drug therapy Candidiasis - microbiology Drug Resistance, Fungal Esophageal Diseases - drug therapy Esophageal Diseases - microbiology Female Fluconazole - pharmacology Fluconazole - therapeutic use Gastroenterology Hepatology Humans Itraconazole - pharmacology Male Medicine Medicine & Public Health Middle Aged Short Report |
| title | Is empiric therapy with fluconazole appropriate for esophageal candidiasis? |
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