Elevated serum levels of lysophosphatidic acid in patients with multiple sclerosis

Abstract A plethora of studies have shown that lysophosphatidic acid (LPA) is involved both in inflammation and T cell apoptosis evasion. The aim of this study was to measure the concentrations of LPA in serum of patients with multiple sclerosis (MS). Twenty MS patients along with 20 age–sex matched healthy individuals were recruited for this investigation. By employment of ELISA method, we demonstrated that MS patients had higher levels of LPA in serum than control group ( P = 0.006). This study is the first report of LPA elevation in MS disease.