Lipoxin A4 modulates adaptive immunity by decreasing memory B‐cell responses via an ALX/FPR2‐dependent mechanism

Specialized proresolving mediators are endogenous bioactive lipid molecules that play a fundamental role in the regulation of inflammation and its resolution. Lipoxins and other specialized proresolving mediators have been identified in important immunological tissues including bone marrow, spleen,...

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Veröffentlicht in:	European journal of immunology 2014-02, Vol.44 (2), p.357-369
Hauptverfasser:	Ramon, Sesquile, Bancos, Simona, Serhan, Charles N., Phipps, Richard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - immunology Adaptor Proteins, Signal Transducing - immunology Animals Antibodies Antibodies - immunology B cells B-Lymphocytes - immunology Cell Proliferation Cells, Cultured Down-Regulation - immunology Human Humans Immunoglobulin G - immunology Immunoglobulin M - immunology Immunologic Memory - immunology Inflammation - immunology Lipoxin Lipoxins - immunology Lymphocyte Activation - immunology Memory responses Mice Mice, Inbred C57BL Protein Transport - immunology Receptors, Formyl Peptide - immunology Receptors, Lipoxin - immunology Signal Transduction - immunology Up-Regulation - immunology
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