Targeted and ultrasound-triggered drug delivery using liposomes co-modified with cancer cell-targeting aptamers and a thermosensitive polymer

•Liposomes were modified with thermosensitive polymer poly(NIPMAM-co-NIPAM).•Thermosensitive polymer (TSP)-modified liposomes became sensitive to ultrasound.•Liposomes were modified with aptamer for platelet-derived growth factor receptors.•Aptamer (APT)-modified liposomes selectively bound to human...

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Veröffentlicht in:	Ultrasonics sonochemistry 2014-07, Vol.21 (4), p.1482-1488
Hauptverfasser:	Ninomiya, Kazuaki, Yamashita, Takahiro, Kawabata, Shinya, Shimizu, Nobuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Aptamers Aptamers, Nucleotide - metabolism Breast Neoplasms - pathology Cavitation Cell Line, Tumor Chemistry Colloidal state and disperse state DNA, Single-Stranded - metabolism Doxorubicin - administration & dosage Doxorubicin - chemistry Doxorubicin - pharmacology Drug delivery Drug Delivery Systems - methods Exact sciences and technology General and physical chemistry Humans Liposomes Membranes Physical chemistry of induced reactions (with radiations, particles and ultrasonics) Temperature Temperature-sensitive liposomes Thermosensitive polymer Ultrasonic chemistry Ultrasonics Ultrasound
Online-Zugang:	Volltext
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