Blood autoantibodies against tumor-associated antigens as biomarkers in early detection of colorectal cancer
Abstract Multiple studies have shown that cancer patients produce detectable autoantibodies against certain tumor-associated antigens, which might be promising blood biomarkers for early detection of colorectal cancer (CRC). We aimed to provide an overview of published studies on blood autoantibody...
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| Veröffentlicht in: | Cancer letters 2014-05, Vol.346 (2), p.178-187 |
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| creator | Chen, Hongda Werner, Simone Tao, Sha Zörnig, Inka Brenner, Hermann |
| description | Abstract Multiple studies have shown that cancer patients produce detectable autoantibodies against certain tumor-associated antigens, which might be promising blood biomarkers for early detection of colorectal cancer (CRC). We aimed to provide an overview of published studies on blood autoantibody markers for early detection of CRC and to summarize their diagnostic performance. A systematic literature search was performed in PubMed, ISI Web of Knowledge and EMBASE to find relevant studies published until 23 July 2013. Relevant information, such as study population characteristics, autoantibodies studied, analytical methods and diagnostic performance characteristics was independently extracted by two reviewers. Overall, 67 studies evaluating 109 autoantibody markers were included. Most individual markers showed low sensitivity (below 25%) for detecting CRC, along with high specificity close to 100%. Occasionally reported higher sensitivities for specific antibodies are yet to be replicated in independent studies. Generally, more promising results were seen for combinations of multiple autoantibody markers. But again, these promising results are yet to be replicated in other samples. In conclusion, autoantibody signatures may become a promising approach to noninvasive CRC screening. Optimized marker panels are yet to be developed, and promising results require validation in large screening populations. |
| doi_str_mv | 10.1016/j.canlet.2014.01.007 |
| format | Article |
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We aimed to provide an overview of published studies on blood autoantibody markers for early detection of CRC and to summarize their diagnostic performance. A systematic literature search was performed in PubMed, ISI Web of Knowledge and EMBASE to find relevant studies published until 23 July 2013. Relevant information, such as study population characteristics, autoantibodies studied, analytical methods and diagnostic performance characteristics was independently extracted by two reviewers. Overall, 67 studies evaluating 109 autoantibody markers were included. Most individual markers showed low sensitivity (below 25%) for detecting CRC, along with high specificity close to 100%. Occasionally reported higher sensitivities for specific antibodies are yet to be replicated in independent studies. Generally, more promising results were seen for combinations of multiple autoantibody markers. But again, these promising results are yet to be replicated in other samples. In conclusion, autoantibody signatures may become a promising approach to noninvasive CRC screening. Optimized marker panels are yet to be developed, and promising results require validation in large screening populations.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2014.01.007</identifier><identifier>PMID: 24462820</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Antibodies, Neoplasm - blood ; Antibodies, Neoplasm - immunology ; Antibody Specificity ; Antigens, Neoplasm - immunology ; Autoantibodies ; Autoantibodies - blood ; Autoantibodies - immunology ; Biomarker ; Biomarkers ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - immunology ; Blood ; Colorectal cancer ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - immunology ; Confidence intervals ; Early detection ; Early Detection of Cancer - methods ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunoassay ; Medical screening ; Proteins ; Studies ; Systematic review</subject><ispartof>Cancer letters, 2014-05, Vol.346 (2), p.178-187</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2014 Elsevier Ireland Ltd</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited May 1, 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-a529357eea2351f860034be006234fb64fdbaafc3b080af7ab00ea03832707533</citedby><cites>FETCH-LOGICAL-c511t-a529357eea2351f860034be006234fb64fdbaafc3b080af7ab00ea03832707533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383514000330$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24462820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Hongda</creatorcontrib><creatorcontrib>Werner, Simone</creatorcontrib><creatorcontrib>Tao, Sha</creatorcontrib><creatorcontrib>Zörnig, Inka</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><title>Blood autoantibodies against tumor-associated antigens as biomarkers in early detection of colorectal cancer</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Abstract Multiple studies have shown that cancer patients produce detectable autoantibodies against certain tumor-associated antigens, which might be promising blood biomarkers for early detection of colorectal cancer (CRC). We aimed to provide an overview of published studies on blood autoantibody markers for early detection of CRC and to summarize their diagnostic performance. A systematic literature search was performed in PubMed, ISI Web of Knowledge and EMBASE to find relevant studies published until 23 July 2013. Relevant information, such as study population characteristics, autoantibodies studied, analytical methods and diagnostic performance characteristics was independently extracted by two reviewers. Overall, 67 studies evaluating 109 autoantibody markers were included. Most individual markers showed low sensitivity (below 25%) for detecting CRC, along with high specificity close to 100%. Occasionally reported higher sensitivities for specific antibodies are yet to be replicated in independent studies. Generally, more promising results were seen for combinations of multiple autoantibody markers. But again, these promising results are yet to be replicated in other samples. In conclusion, autoantibody signatures may become a promising approach to noninvasive CRC screening. Optimized marker panels are yet to be developed, and promising results require validation in large screening populations.</description><subject>Antibodies, Neoplasm - blood</subject><subject>Antibodies, Neoplasm - immunology</subject><subject>Antibody Specificity</subject><subject>Antigens, Neoplasm - immunology</subject><subject>Autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Autoantibodies - immunology</subject><subject>Biomarker</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - immunology</subject><subject>Blood</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - immunology</subject><subject>Confidence intervals</subject><subject>Early detection</subject><subject>Early Detection of Cancer - methods</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Medical screening</subject><subject>Proteins</subject><subject>Studies</subject><subject>Systematic review</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-LFDEQxYMo7uzqNxBp8OKlx8q_Ts9FcBddhQUP6jlUp6uXzGY6a5IW5tubZlaFvXgKBb-q1HuvGHvFYcuBd-_2W4dzoLIVwNUW-BbAPGEb3hvRml0PT9kGJKhW9lKfsfOc9wCgldHP2ZlQqhO9gA0LlyHGscGlRJyLH-LoKTd4i37OpSnLIaYWc47OY6HKVeaW5krkZvDxgOmOUm783BCmcGxGKuSKj3MTp8bFEFMtMTR1VUfpBXs2Ycj08uG9YD8-ffx-9bm9-Xr95erDTes056VFLXZSGyIUUvOp7wCkGgigE1JNQ6emcUCcnBygB5wMDgCEUIUKA0ZLecHenubep_hzoVzswWdHIeBMccmW6-og52InKvrmEbqPS5rrdpXSpoNeGqiUOlEuxZwTTfY--Sr-aDnYNQ27t6c07JqGBW5rGrXt9cPwZTjQ-Lfpj_0VeH8CqLrxy1Oy2XmqVo1-Nc6O0f_vh8cDXPCzdxju6Ej5nxabhQX7bb2I9SC4qscgJcjfELqyLw</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Chen, Hongda</creator><creator>Werner, Simone</creator><creator>Tao, Sha</creator><creator>Zörnig, Inka</creator><creator>Brenner, Hermann</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20140501</creationdate><title>Blood autoantibodies against tumor-associated antigens as biomarkers in early detection of colorectal cancer</title><author>Chen, Hongda ; Werner, Simone ; Tao, Sha ; Zörnig, Inka ; Brenner, Hermann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-a529357eea2351f860034be006234fb64fdbaafc3b080af7ab00ea03832707533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antibodies, Neoplasm - blood</topic><topic>Antibodies, Neoplasm - immunology</topic><topic>Antibody Specificity</topic><topic>Antigens, Neoplasm - immunology</topic><topic>Autoantibodies</topic><topic>Autoantibodies - blood</topic><topic>Autoantibodies - immunology</topic><topic>Biomarker</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - immunology</topic><topic>Blood</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - immunology</topic><topic>Confidence intervals</topic><topic>Early detection</topic><topic>Early Detection of Cancer - methods</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Medical screening</topic><topic>Proteins</topic><topic>Studies</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Hongda</creatorcontrib><creatorcontrib>Werner, Simone</creatorcontrib><creatorcontrib>Tao, Sha</creatorcontrib><creatorcontrib>Zörnig, Inka</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Hongda</au><au>Werner, Simone</au><au>Tao, Sha</au><au>Zörnig, Inka</au><au>Brenner, Hermann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood autoantibodies against tumor-associated antigens as biomarkers in early detection of colorectal cancer</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>346</volume><issue>2</issue><spage>178</spage><epage>187</epage><pages>178-187</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Abstract Multiple studies have shown that cancer patients produce detectable autoantibodies against certain tumor-associated antigens, which might be promising blood biomarkers for early detection of colorectal cancer (CRC). We aimed to provide an overview of published studies on blood autoantibody markers for early detection of CRC and to summarize their diagnostic performance. A systematic literature search was performed in PubMed, ISI Web of Knowledge and EMBASE to find relevant studies published until 23 July 2013. Relevant information, such as study population characteristics, autoantibodies studied, analytical methods and diagnostic performance characteristics was independently extracted by two reviewers. Overall, 67 studies evaluating 109 autoantibody markers were included. Most individual markers showed low sensitivity (below 25%) for detecting CRC, along with high specificity close to 100%. Occasionally reported higher sensitivities for specific antibodies are yet to be replicated in independent studies. Generally, more promising results were seen for combinations of multiple autoantibody markers. But again, these promising results are yet to be replicated in other samples. In conclusion, autoantibody signatures may become a promising approach to noninvasive CRC screening. Optimized marker panels are yet to be developed, and promising results require validation in large screening populations.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>24462820</pmid><doi>10.1016/j.canlet.2014.01.007</doi><tpages>10</tpages></addata></record> |
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| subjects | Antibodies, Neoplasm - blood Antibodies, Neoplasm - immunology Antibody Specificity Antigens, Neoplasm - immunology Autoantibodies Autoantibodies - blood Autoantibodies - immunology Biomarker Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - immunology Blood Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - diagnosis Colorectal Neoplasms - immunology Confidence intervals Early detection Early Detection of Cancer - methods Hematology, Oncology and Palliative Medicine Humans Immunoassay Medical screening Proteins Studies Systematic review |
| title | Blood autoantibodies against tumor-associated antigens as biomarkers in early detection of colorectal cancer |
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