Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in atypical vascular lesions, primary or radiation-induced mammary angiosarcomas, and primary angiosarcomas of other sites

Summary Breast cancer patients who receive radiation therapy or develop chronic lymphedema following axillary dissection can develop secondary mammary angiosarcomas (ASs) and, additionally, atypical vascular lesions (AVLs) in the former group. Recently, MYC amplification by fluorescence in situ hybr...

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Veröffentlicht in:	Human pathology 2014-04, Vol.45 (4), p.709-716
Hauptverfasser:	Ginter, Paula S., MD, Mosquera, Juan Miguel, MD, MSc, MacDonald, Theresa Y., BS, D'Alfonso, Timothy M., MD, Rubin, Mark A., MD, Shin, Sandra J., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Atypical vascular lesion Breast - pathology Breast - radiation effects Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - metabolism Female Gene Amplification Genes, myc - genetics Hemangiosarcoma - diagnosis Hemangiosarcoma - genetics Hemangiosarcoma - metabolism Humans Immunohistochemistry In Situ Hybridization, Fluorescence Middle Aged MYC Neoplasms, Radiation-Induced - diagnosis Neoplasms, Radiation-Induced - genetics Neoplasms, Radiation-Induced - metabolism Pathology Radiation Radiotherapy - adverse effects Secondary angiosarcoma Tissue Array Analysis Young Adult
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