Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

Background & Aims Hepatitis B and D viruses (HBV and HDV) are human pathogens with restricted host ranges and high selectivity for hepatocytes; the HBV L-envelope protein interacts specifically with a receptor on these cells. We aimed to identify this receptor and analyze whether it is the recen...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2014-04, Vol.146 (4), p.1070-1083.e6
Hauptverfasser:	Ni, Yi, Lempp, Florian A, Mehrle, Stefan, Nkongolo, Shirin, Kaufman, Christina, Fälth, Maria, Stindt, Jan, Königer, Christian, Nassal, Michael, Kubitz, Ralf, Sültmann, Holger, Urban, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Computational Biology Gastroenterology and Hepatology Gene Expression Profiling - methods Hep G2 Cells Hepatitis B virus - physiology Hepatitis Delta Virus - physiology Hepatocytes - metabolism Hepatocytes - virology Host-Pathogen Interactions Humans Ligands Lipopeptides - metabolism Mice Myrcludex B Oligonucleotide Array Sequence Analysis Organic Anion Transporters, Sodium-Dependent - genetics Organic Anion Transporters, Sodium-Dependent - metabolism Protein Interaction Domains and Motifs Protein Interaction Mapping Rats RNA Interference Species Specificity Symporters - genetics Symporters - metabolism Taurocholic Acid - metabolism Time Factors Transfection Viral Envelope Proteins - metabolism Virology Virus Attachment Virus Entry Virus Internalization
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