GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

Glucagon-like peptide 1 (GLP-1) analogs are increasingly being used in the treatment of type 2 diabetes. It is clear that these drugs lower blood glucose through an increase in insulin secretion and a lowering of glucagon secretion; in addition, they lower body weight and systolic blood pressure and...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2014-04, Vol.155 (4), p.1280-1290
Hauptverfasser:	Pyke, Charles, Heller, R. Scott, Kirk, Rikke K, Ørskov, Cathrine, Reedtz-Runge, Steffen, Kaastrup, Peter, Hvelplund, Anders, Bardram, Linda, Calatayud, Dan, Knudsen, Lotte Bjerre
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar cells Analogs Animals Antibodies, Monoclonal - chemistry Arteries Arterioles Beta cells Blood Pressure Body Weight Cardiac muscle Cell Line Cricetinae Diabetes mellitus (non-insulin dependent) Duodenum Duodenum - metabolism Enteric nervous system Epithelial cells Epithelium Exenatide Gastrointestinal system Gastrointestinal tract Glucagon Glucagon - metabolism Glucagon-like peptide 1 Glucagon-Like Peptide 1 - analogs & derivatives Glucagon-Like Peptide 1 - chemistry Glucagon-Like Peptide-1 Receptor Haplorhini Heart Rate Hepatocytes Human tissues Humans Immunohistochemistry Insulin - metabolism Insulin Secretion Ligands Liraglutide Localization Mice Mice, Inbred C57BL Mice, Knockout Mode of action Monkeys Monoclonal antibodies Muscles Myenteric plexus Myocytes Parietal cells Peptides - chemistry Protein Binding Receptors Receptors, Glucagon - metabolism Smooth muscle Thyroid Tissue Distribution Transfection Venoms - chemistry
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