PRADIMICIN, A NOVEL CLASS OF POTENT ANTIFUNGAL ANTIBIOTICS

PRADIMICIN, A NOVEL CLASS OF POTENT ANTIFUNGAL ANTIBIOTICS

An actinomycete strain No. P157-2 that had been isolated from a soil sample collected in Fiji Island was found to produce novel antibiotics, pradimicins A and B. Pradimicin A, the major component showed moderate in vitro activity against a wide variety of fungi and yeasts including clinically import...

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Veröffentlicht in:Journal of antibiotics 1988/11/25, Vol.41(11), pp.1701-1704
Hauptverfasser: OKI, TOSHIKAZU, KONISHI, MASATAKA, TOMATSU, Kozo, TOMITA, KOJI, SAITOH, KYO-ICHIRO, TSUNAKAWA, MLTSUAKI, NISHIO, MAKI, MIYAKI, TAKEO, KAWAGUCHI, HIROSHI
Format: Artikel
Sprache:eng
Schlagworte:
Actinomadura hibisca
antifungal agents
pradimicin
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Beschreibung
Zusammenfassung:An actinomycete strain No. P157-2 that had been isolated from a soil sample collected in Fiji Island was found to produce novel antibiotics, pradimicins A and B. Pradimicin A, the major component showed moderate in vitro activity against a wide variety of fungi and yeasts including clinically important pathogens. This communication presents production, isolation, chemical and biological properties and structures of pradimicins A and B. Based on the taxonomic studies performed, strain P157-2 is classified as a heretofore undescribed species of the genus Actinomadura and named Actinomadura hibisca sp. nov.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.41.1701