Prostate cancer detection with real-time elastography using a bi-plane transducer: comparison with step section radical prostatectomy pathology
Purpose To evaluate elastography using a bi-plane transducer for localizing prostate cancer (PCa) in patients scheduled for radical prostatectomy (RP), in comparison with step section pathological analysis. Methods Fifty-six consecutive PCa patients underwent real-time elastography examination with...
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| Veröffentlicht in: | World journal of urology 2014-04, Vol.32 (2), p.329-333 |
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| creator | Zhu, Yunkai Chen, Yaqing Qi, Tingyue Jiang, Jun Qi, Jun Yu, Yongjiang Yao, Xiaohong Guan, Wenbin |
| description | Purpose
To evaluate elastography using a bi-plane transducer for localizing prostate cancer (PCa) in patients scheduled for radical prostatectomy (RP), in comparison with step section pathological analysis.
Methods
Fifty-six consecutive PCa patients underwent real-time elastography examination with a bi-plane transducer before RP. Transverse elastographic images were obtained from the apex to the base by slightly compressing and releasing the prostate tissue using the probe. The diagnostic performance of elastography was evaluated in correlation with step section RP histopathology.
Results
In 56 PCa patients, gray-scale ultrasonography detected at least one lesion in 36 patients, whereas elastography detected at least one lesion in 53 patients (
P
= 0.001). The overall sensitivity, specificity and accuracy of elastography in depicting tumor lesions were 67.6, 89.5 and 82.7 %, respectively. The detection rate of a PCa lesion with elastography was best in the left posterior region, followed by the right posterior region. Elastography was more sensitive in detecting PCa lesions with higher Gleason scores, diameter >5 mm and extracapsular extension.
Conclusions
The additional use of elastography with the bi-plane transducer can improve PCa detection rate by providing more information about tissue stiffness within the prostate gland. |
| doi_str_mv | 10.1007/s00345-012-0922-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1509414092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1509414092</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-5e8981bd199ec7e1e880795a967da6eaca5303fd0a4e5ba50567347e906d8ebe3</originalsourceid><addsrcrecordid>eNp1kcuKFDEUhoMoTtv6AG4k4MZNNNdK4k4GdQYGdKHr4lTqdHcNVZUySSH9FL6yabpHRHCVRb7znctPyEvB3wrO7bvMudKGcSEZ91Iy8YhshFaKOSubx2TDrdRMe6euyLOc7zkXtuHmKbmS0jnTGLchv76mmAsUpAHmgIn2WDCUIc7051AONCGMrAwTUhwhl7hPsByOdM3DvKdAu4EtI8xIS4I592s1vKchTgukIT84csGF5os1QT8EGOly6RtKnI50gXKIY9wfn5MnOxgzvri8W_L908dv1zfs7svn2-sPdywoKwsz6LwTXS-8x2BRoHPcegO-sT00CAGM4mrXc9BoOjDcNFZpi543vcMO1Za8OXvrHD9WzKWdhhxwPC0T19wKw70Wup61oq__Qe_jmuY63YlyXmpVb74l4kyFulhOuGuXNEyQjq3g7Smt9pxWW9NqT2m1ota8upjXbsL-T8VDPBWQZyDXr3mP6a_W_7X-Bmg0osU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1508924343</pqid></control><display><type>article</type><title>Prostate cancer detection with real-time elastography using a bi-plane transducer: comparison with step section radical prostatectomy pathology</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zhu, Yunkai ; Chen, Yaqing ; Qi, Tingyue ; Jiang, Jun ; Qi, Jun ; Yu, Yongjiang ; Yao, Xiaohong ; Guan, Wenbin</creator><creatorcontrib>Zhu, Yunkai ; Chen, Yaqing ; Qi, Tingyue ; Jiang, Jun ; Qi, Jun ; Yu, Yongjiang ; Yao, Xiaohong ; Guan, Wenbin</creatorcontrib><description>Purpose
To evaluate elastography using a bi-plane transducer for localizing prostate cancer (PCa) in patients scheduled for radical prostatectomy (RP), in comparison with step section pathological analysis.
Methods
Fifty-six consecutive PCa patients underwent real-time elastography examination with a bi-plane transducer before RP. Transverse elastographic images were obtained from the apex to the base by slightly compressing and releasing the prostate tissue using the probe. The diagnostic performance of elastography was evaluated in correlation with step section RP histopathology.
Results
In 56 PCa patients, gray-scale ultrasonography detected at least one lesion in 36 patients, whereas elastography detected at least one lesion in 53 patients (
P
= 0.001). The overall sensitivity, specificity and accuracy of elastography in depicting tumor lesions were 67.6, 89.5 and 82.7 %, respectively. The detection rate of a PCa lesion with elastography was best in the left posterior region, followed by the right posterior region. Elastography was more sensitive in detecting PCa lesions with higher Gleason scores, diameter >5 mm and extracapsular extension.
Conclusions
The additional use of elastography with the bi-plane transducer can improve PCa detection rate by providing more information about tissue stiffness within the prostate gland.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-012-0922-1</identifier><identifier>PMID: 22885658</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - pathology ; Aged ; Cohort Studies ; Elasticity Imaging Techniques - instrumentation ; Elasticity Imaging Techniques - methods ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Grading ; Nephrology ; Oncology ; Original Article ; Prostate - diagnostic imaging ; Prostate - pathology ; Prostatectomy ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - diagnostic imaging ; Prostatic Neoplasms - pathology ; Retrospective Studies ; Sensitivity and Specificity ; Transducers ; Urology</subject><ispartof>World journal of urology, 2014-04, Vol.32 (2), p.329-333</ispartof><rights>Springer-Verlag 2012</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-5e8981bd199ec7e1e880795a967da6eaca5303fd0a4e5ba50567347e906d8ebe3</citedby><cites>FETCH-LOGICAL-c372t-5e8981bd199ec7e1e880795a967da6eaca5303fd0a4e5ba50567347e906d8ebe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-012-0922-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-012-0922-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22885658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Yunkai</creatorcontrib><creatorcontrib>Chen, Yaqing</creatorcontrib><creatorcontrib>Qi, Tingyue</creatorcontrib><creatorcontrib>Jiang, Jun</creatorcontrib><creatorcontrib>Qi, Jun</creatorcontrib><creatorcontrib>Yu, Yongjiang</creatorcontrib><creatorcontrib>Yao, Xiaohong</creatorcontrib><creatorcontrib>Guan, Wenbin</creatorcontrib><title>Prostate cancer detection with real-time elastography using a bi-plane transducer: comparison with step section radical prostatectomy pathology</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Purpose
To evaluate elastography using a bi-plane transducer for localizing prostate cancer (PCa) in patients scheduled for radical prostatectomy (RP), in comparison with step section pathological analysis.
Methods
Fifty-six consecutive PCa patients underwent real-time elastography examination with a bi-plane transducer before RP. Transverse elastographic images were obtained from the apex to the base by slightly compressing and releasing the prostate tissue using the probe. The diagnostic performance of elastography was evaluated in correlation with step section RP histopathology.
Results
In 56 PCa patients, gray-scale ultrasonography detected at least one lesion in 36 patients, whereas elastography detected at least one lesion in 53 patients (
P
= 0.001). The overall sensitivity, specificity and accuracy of elastography in depicting tumor lesions were 67.6, 89.5 and 82.7 %, respectively. The detection rate of a PCa lesion with elastography was best in the left posterior region, followed by the right posterior region. Elastography was more sensitive in detecting PCa lesions with higher Gleason scores, diameter >5 mm and extracapsular extension.
Conclusions
The additional use of elastography with the bi-plane transducer can improve PCa detection rate by providing more information about tissue stiffness within the prostate gland.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Cohort Studies</subject><subject>Elasticity Imaging Techniques - instrumentation</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prostate - diagnostic imaging</subject><subject>Prostate - pathology</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Transducers</subject><subject>Urology</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kcuKFDEUhoMoTtv6AG4k4MZNNNdK4k4GdQYGdKHr4lTqdHcNVZUySSH9FL6yabpHRHCVRb7znctPyEvB3wrO7bvMudKGcSEZ91Iy8YhshFaKOSubx2TDrdRMe6euyLOc7zkXtuHmKbmS0jnTGLchv76mmAsUpAHmgIn2WDCUIc7051AONCGMrAwTUhwhl7hPsByOdM3DvKdAu4EtI8xIS4I592s1vKchTgukIT84csGF5os1QT8EGOly6RtKnI50gXKIY9wfn5MnOxgzvri8W_L908dv1zfs7svn2-sPdywoKwsz6LwTXS-8x2BRoHPcegO-sT00CAGM4mrXc9BoOjDcNFZpi543vcMO1Za8OXvrHD9WzKWdhhxwPC0T19wKw70Wup61oq__Qe_jmuY63YlyXmpVb74l4kyFulhOuGuXNEyQjq3g7Smt9pxWW9NqT2m1ota8upjXbsL-T8VDPBWQZyDXr3mP6a_W_7X-Bmg0osU</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Zhu, Yunkai</creator><creator>Chen, Yaqing</creator><creator>Qi, Tingyue</creator><creator>Jiang, Jun</creator><creator>Qi, Jun</creator><creator>Yu, Yongjiang</creator><creator>Yao, Xiaohong</creator><creator>Guan, Wenbin</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Prostate cancer detection with real-time elastography using a bi-plane transducer: comparison with step section radical prostatectomy pathology</title><author>Zhu, Yunkai ; Chen, Yaqing ; Qi, Tingyue ; Jiang, Jun ; Qi, Jun ; Yu, Yongjiang ; Yao, Xiaohong ; Guan, Wenbin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-5e8981bd199ec7e1e880795a967da6eaca5303fd0a4e5ba50567347e906d8ebe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Cohort Studies</topic><topic>Elasticity Imaging Techniques - instrumentation</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Nephrology</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prostate - diagnostic imaging</topic><topic>Prostate - pathology</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - diagnostic imaging</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Transducers</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Yunkai</creatorcontrib><creatorcontrib>Chen, Yaqing</creatorcontrib><creatorcontrib>Qi, Tingyue</creatorcontrib><creatorcontrib>Jiang, Jun</creatorcontrib><creatorcontrib>Qi, Jun</creatorcontrib><creatorcontrib>Yu, Yongjiang</creatorcontrib><creatorcontrib>Yao, Xiaohong</creatorcontrib><creatorcontrib>Guan, Wenbin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Yunkai</au><au>Chen, Yaqing</au><au>Qi, Tingyue</au><au>Jiang, Jun</au><au>Qi, Jun</au><au>Yu, Yongjiang</au><au>Yao, Xiaohong</au><au>Guan, Wenbin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostate cancer detection with real-time elastography using a bi-plane transducer: comparison with step section radical prostatectomy pathology</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>32</volume><issue>2</issue><spage>329</spage><epage>333</epage><pages>329-333</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Purpose
To evaluate elastography using a bi-plane transducer for localizing prostate cancer (PCa) in patients scheduled for radical prostatectomy (RP), in comparison with step section pathological analysis.
Methods
Fifty-six consecutive PCa patients underwent real-time elastography examination with a bi-plane transducer before RP. Transverse elastographic images were obtained from the apex to the base by slightly compressing and releasing the prostate tissue using the probe. The diagnostic performance of elastography was evaluated in correlation with step section RP histopathology.
Results
In 56 PCa patients, gray-scale ultrasonography detected at least one lesion in 36 patients, whereas elastography detected at least one lesion in 53 patients (
P
= 0.001). The overall sensitivity, specificity and accuracy of elastography in depicting tumor lesions were 67.6, 89.5 and 82.7 %, respectively. The detection rate of a PCa lesion with elastography was best in the left posterior region, followed by the right posterior region. Elastography was more sensitive in detecting PCa lesions with higher Gleason scores, diameter >5 mm and extracapsular extension.
Conclusions
The additional use of elastography with the bi-plane transducer can improve PCa detection rate by providing more information about tissue stiffness within the prostate gland.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>22885658</pmid><doi>10.1007/s00345-012-0922-1</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0724-4983 |
| ispartof | World journal of urology, 2014-04, Vol.32 (2), p.329-333 |
| issn | 0724-4983 1433-8726 |
| language | eng |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - diagnostic imaging Adenocarcinoma - pathology Aged Cohort Studies Elasticity Imaging Techniques - instrumentation Elasticity Imaging Techniques - methods Humans Male Medicine Medicine & Public Health Middle Aged Neoplasm Grading Nephrology Oncology Original Article Prostate - diagnostic imaging Prostate - pathology Prostatectomy Prostatic Neoplasms - diagnosis Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - pathology Retrospective Studies Sensitivity and Specificity Transducers Urology |
| title | Prostate cancer detection with real-time elastography using a bi-plane transducer: comparison with step section radical prostatectomy pathology |
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