Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review)

Endometriosis is a complex disease influenced by genetic, epigenetic and environmental factors. The aim of the present study was to describe genomic instability, genetic polymorphisms and their haplotype, epigenetic alterations associated with predisposition to endometriosis, and the key factors ass...

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Veröffentlicht in:	Molecular medicine reports 2014-05, Vol.9 (5), p.1483-1505
Hauptverfasser:	KOBAYASHI, HIROSHI, IMANAKA, SHOGO, NAKAMURA, HARUKI, TSUJI, AYUMI
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antioxidants Apoptosis Cancer Care and treatment Cell cycle Cell division Cell Transformation, Neoplastic - genetics Copy number Cyclin-dependent kinases Cytokines Deoxyribonucleic acid Development and progression DNA DNA methylation DNA, Mitochondrial Endometriosis Endometriosis - epidemiology Endometriosis - genetics environment Environmental changes Environmental factors Epidermal growth factor Epigenesis, Genetic epigenetic Epigenetic inheritance Epigenetics Female Gene expression Gene regulation Genes genetic Genetic Variation Genomic Instability Genomics Haplotypes Health aspects Heterozygosity Humans Inflammation Iron Kinases Loss of heterozygosity Menstruation Mitochondrial DNA Mutation Oxidative stress Polymorphism, Single Nucleotide Proteins Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Tumors
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