Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

GLP-1 is an intestinal hormone with widespread actions on metabolism. Therapies based on GLP-1 are highly effective because they increase glucose-dependent insulin secretion in people with type 2 diabetes, but many reports suggest that GLP-1 has additional beneficial or, in some cases, potentially d...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2014-04, Vol.63 (4), p.1224-1233
Hauptverfasser:	RICHARDS, Paul, PARKER, Helen E, ADRIAENSSENS, Alice E, HODGSON, Joshua M, CORK, Simon C, TRAPP, Stefan, GRIBBLE, Fiona M, REIMANN, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological and medical sciences Cardiomyocytes Central Nervous System - cytology Central Nervous System - metabolism Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gastrointestinal hormones Glucagon-Like Peptide-1 Receptor Glucose Heart Atria - cytology Heart Atria - metabolism Hormones Insulin Islets of Langerhans - cytology Islets of Langerhans - metabolism Medical sciences Metabolism Mice Mice, Transgenic Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Physiological aspects Receptors, Glucagon - biosynthesis Rodents
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