Glycation of Apolipoprotein C1 Impairs Its CETP Inhibitory Property: Pathophysiological Relevance in Patients With Type 1 and Type 2 Diabetes

OBJECTIVE Apolipoprotein (apo)C1 is a potent physiological inhibitor of cholesteryl ester transfer protein (CETP). ApoC1 operates through its ability to modify the electrostatic charge at the lipoprotein surface. We aimed to determine whether the inhibitory ability of apoC1 is still effective in viv...

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Veröffentlicht in:	Diabetes care 2014-04, Vol.37 (4), p.1148-1156
Hauptverfasser:	BOUILLET, Benjamin, GAUTIER, Thomas, BLACHE, Denis, DE BARROS, Jean-Paul Pais, DUVILLARD, Laurence, PETIT, Jean-Michel, LAGROST, Laurent, VERGES, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apolipoprotein C-I - metabolism Biological and medical sciences Cholesterol Ester Transfer Proteins - antagonists & inhibitors Cholesterol Ester Transfer Proteins - blood Control Correlation analysis Diabetes Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetes therapy Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glucose - metabolism Humans Male Medical sciences Metabolic diseases Middle Aged Physiological aspects Proteins Type 2 diabetes
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