Cisatracurium pretreatment with tourniquet reduces propofol injection pain: A double-blind randomized controlled trial
Objectives To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine. Methods Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0...
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| Veröffentlicht in: | Journal of international medical research 2014-04, Vol.42 (2), p.360-367 |
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| creator | Kim, Yun-Hee Namgung, Jin Lim, Choon-Hak |
| description | Objectives
To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine.
Methods
Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5 mg/kg), 0.03 mg/kg cisatracurium or 0.15 mg/kg cisatracurium. All drugs were administered into the largest dorsal vein of the hand with venous occlusion for 30 s, followed by propofol (0.5 mg/kg). Pain was evaluated using a four-point scale.
Results
The incidence and severity of pain was significantly lower in the lidocaine and 0.15 mg/kg cisatracurium groups than the control and 0.03 mg/kg cisatracurium groups (n = 50/group). There was no significant difference between the lidocaine and 0.15 mg/kg cisatracurium groups in the incidence and severity of pain.
Conclusions
0.15 mg/kg cisatracurium effectively decreases the incidence and severity of pain induced by propofol injection without any significant complications. |
| doi_str_mv | 10.1177/0300060514522602 |
| format | Article |
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To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine.
Methods
Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5 mg/kg), 0.03 mg/kg cisatracurium or 0.15 mg/kg cisatracurium. All drugs were administered into the largest dorsal vein of the hand with venous occlusion for 30 s, followed by propofol (0.5 mg/kg). Pain was evaluated using a four-point scale.
Results
The incidence and severity of pain was significantly lower in the lidocaine and 0.15 mg/kg cisatracurium groups than the control and 0.03 mg/kg cisatracurium groups (n = 50/group). There was no significant difference between the lidocaine and 0.15 mg/kg cisatracurium groups in the incidence and severity of pain.
Conclusions
0.15 mg/kg cisatracurium effectively decreases the incidence and severity of pain induced by propofol injection without any significant complications.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/0300060514522602</identifier><identifier>PMID: 24573971</identifier><identifier>CODEN: JIMRBV</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia, General - adverse effects ; Anesthetics, Intravenous - administration & dosage ; Anesthetics, Local - administration & dosage ; Atracurium - analogs & derivatives ; Atracurium - therapeutic use ; Biological and medical sciences ; Double-Blind Method ; Female ; Humans ; Lidocaine - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Neuromuscular Blocking Agents - therapeutic use ; Pain - prevention & control ; Pain Management ; Pain Measurement ; Pharmacology. Drug treatments ; Propofol - administration & dosage ; Prospective Studies ; Tourniquets ; Young Adult</subject><ispartof>Journal of international medical research, 2014-04, Vol.42 (2), p.360-367</ispartof><rights>The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-a55d7e7bfe4fcb4a1d7fd1b78fdd7bba92884cbd29114d9207546a1862ed3c923</citedby><cites>FETCH-LOGICAL-c409t-a55d7e7bfe4fcb4a1d7fd1b78fdd7bba92884cbd29114d9207546a1862ed3c923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0300060514522602$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0300060514522602$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,862,21953,27840,27911,27912,44932,45320</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28388413$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24573971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Yun-Hee</creatorcontrib><creatorcontrib>Namgung, Jin</creatorcontrib><creatorcontrib>Lim, Choon-Hak</creatorcontrib><title>Cisatracurium pretreatment with tourniquet reduces propofol injection pain: A double-blind randomized controlled trial</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>Objectives
To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine.
Methods
Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5 mg/kg), 0.03 mg/kg cisatracurium or 0.15 mg/kg cisatracurium. All drugs were administered into the largest dorsal vein of the hand with venous occlusion for 30 s, followed by propofol (0.5 mg/kg). Pain was evaluated using a four-point scale.
Results
The incidence and severity of pain was significantly lower in the lidocaine and 0.15 mg/kg cisatracurium groups than the control and 0.03 mg/kg cisatracurium groups (n = 50/group). There was no significant difference between the lidocaine and 0.15 mg/kg cisatracurium groups in the incidence and severity of pain.
Conclusions
0.15 mg/kg cisatracurium effectively decreases the incidence and severity of pain induced by propofol injection without any significant complications.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia, General - adverse effects</subject><subject>Anesthetics, Intravenous - administration & dosage</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Atracurium - analogs & derivatives</subject><subject>Atracurium - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Lidocaine - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuromuscular Blocking Agents - therapeutic use</subject><subject>Pain - prevention & control</subject><subject>Pain Management</subject><subject>Pain Measurement</subject><subject>Pharmacology. Drug treatments</subject><subject>Propofol - administration & dosage</subject><subject>Prospective Studies</subject><subject>Tourniquets</subject><subject>Young Adult</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp1kM1r2zAUwMVoabKs956GLoVdvEmybNm7hbB2g8Iu3dno43lVkKVUklvav74KyToo9KSH3u99_RC6oOQrpUJ8IzUhpCUN5Q1jLWEf0JJyUVes_J-g5T5d7fML9DGlLSGctQ07QwvGG1H3gi7Rw8YmmaPUc7TzhHcRcgSZJ_AZP9p8h3OYo7f3M2QcwcwaUoHCLozBYeu3oLMNHu-k9d_xGpswKweVctYbHKU3YbLPYLAOPsfgXAlztNJ9QqejdAnOj-8K_bn6cbv5Wd38vv61Wd9UmpM-V7JpjAChRuCjVlxSI0ZDlehGY4RSsmddx7UyrKeUm54R0fBW0q5lYGrds3qFvhz6lp3LDSkPk00anJMewpwG2pCeU9L2pKDkgOoYUoowDrtoJxmfBkqGve3hre1S8vnYfVYTmNeCf3oLcHkEZNLSjcWItuk_19Vlf1oXrjpwSf6FYbtXXqy8P_gFYyuWwg</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Kim, Yun-Hee</creator><creator>Namgung, Jin</creator><creator>Lim, Choon-Hak</creator><general>SAGE Publications</general><general>Sage Publications</general><scope>AFRWT</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Cisatracurium pretreatment with tourniquet reduces propofol injection pain: A double-blind randomized controlled trial</title><author>Kim, Yun-Hee ; Namgung, Jin ; Lim, Choon-Hak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-a55d7e7bfe4fcb4a1d7fd1b78fdd7bba92884cbd29114d9207546a1862ed3c923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia, General - adverse effects</topic><topic>Anesthetics, Intravenous - administration & dosage</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Atracurium - analogs & derivatives</topic><topic>Atracurium - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Lidocaine - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuromuscular Blocking Agents - therapeutic use</topic><topic>Pain - prevention & control</topic><topic>Pain Management</topic><topic>Pain Measurement</topic><topic>Pharmacology. Drug treatments</topic><topic>Propofol - administration & dosage</topic><topic>Prospective Studies</topic><topic>Tourniquets</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Yun-Hee</creatorcontrib><creatorcontrib>Namgung, Jin</creatorcontrib><creatorcontrib>Lim, Choon-Hak</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Yun-Hee</au><au>Namgung, Jin</au><au>Lim, Choon-Hak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cisatracurium pretreatment with tourniquet reduces propofol injection pain: A double-blind randomized controlled trial</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>42</volume><issue>2</issue><spage>360</spage><epage>367</epage><pages>360-367</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><coden>JIMRBV</coden><abstract>Objectives
To investigate the efficacy of pretreatment with cisatracurium for prevention of pain associated with propofol injection, and compare its efficacy with that of lidocaine.
Methods
Patients undergoing general anaesthesia were randomized to receive normal saline (control group), lidocaine (0.5 mg/kg), 0.03 mg/kg cisatracurium or 0.15 mg/kg cisatracurium. All drugs were administered into the largest dorsal vein of the hand with venous occlusion for 30 s, followed by propofol (0.5 mg/kg). Pain was evaluated using a four-point scale.
Results
The incidence and severity of pain was significantly lower in the lidocaine and 0.15 mg/kg cisatracurium groups than the control and 0.03 mg/kg cisatracurium groups (n = 50/group). There was no significant difference between the lidocaine and 0.15 mg/kg cisatracurium groups in the incidence and severity of pain.
Conclusions
0.15 mg/kg cisatracurium effectively decreases the incidence and severity of pain induced by propofol injection without any significant complications.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>24573971</pmid><doi>10.1177/0300060514522602</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of international medical research, 2014-04, Vol.42 (2), p.360-367 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Sage Journals GOLD Open Access 2024; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Anesthesia, General - adverse effects Anesthetics, Intravenous - administration & dosage Anesthetics, Local - administration & dosage Atracurium - analogs & derivatives Atracurium - therapeutic use Biological and medical sciences Double-Blind Method Female Humans Lidocaine - therapeutic use Male Medical sciences Middle Aged Neuromuscular Blocking Agents - therapeutic use Pain - prevention & control Pain Management Pain Measurement Pharmacology. Drug treatments Propofol - administration & dosage Prospective Studies Tourniquets Young Adult |
| title | Cisatracurium pretreatment with tourniquet reduces propofol injection pain: A double-blind randomized controlled trial |
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