Osterix and NO66 Histone Demethylase Control the Chromatin of Osterix Target Genes During Osteoblast Differentiation

ABSTRACT Commitment of Runx2‐expressing precursor osteoblasts to functional osteoblasts and then to osteocytes is triggered by Osterix (Osx), which activates its target genes in those cells during bone formation. It is not yet known whether Osx has a role in remodeling the chromatin architecture of...

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Veröffentlicht in:	Journal of bone and mineral research 2014-04, Vol.29 (4), p.855-865
Hauptverfasser:	Sinha, Krishna M, Yasuda, Hideyo, Zhou, Xin, deCrombrugghe, Benoit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Development - genetics Cell Differentiation CHROMATIN Chromatin - metabolism Chromosomal Proteins, Non-Histone - physiology Dioxygenases DNA METHYLATION Epigenesis, Genetic HISTONE DEMETHYLASE Histone Demethylases - physiology Integrin-Binding Sialoprotein - genetics Mice NO66 OSTEOBLASTS Osteoblasts - cytology OSTERIX Promoter Regions, Genetic Real-Time Polymerase Chain Reaction Sp7 Transcription Factor Transcription Factors - genetics Transcription Factors - physiology
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