EphA4 Receptor Is a Novel Negative Regulator of Osteoclast Activity

ABSTRACT Of the ephrin (Eph) receptors, mature osteoclasts express predominantly EphA4. This study sought to determine if EphA4 has a regulatory role in osteoclasts. Treatment of RAW/C4 cells with Epha4 small interfering RNAs (siRNAs) increased average size, Ctsk mRNA expression level, and bone reso...

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Veröffentlicht in:	Journal of bone and mineral research 2014-04, Vol.29 (4), p.804-819
Hauptverfasser:	Stiffel, Virginia, Amoui, Mehran, Sheng, Matilda H‐C, Mohan, Subburaman, Lau, K‐H William
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Remodeling Cell Line CELL/TISSUE SIGNALING, PARACRINE PATHWAY, OTHERS (EPHA4 SIGNALING) GENETIC ANIMAL MODELS Mice Mice, Inbred C57BL MOLECULAR PATHWAYS, REMODELING OSTEOCLASTS Osteoclasts - cytology OSTEOPOROSIS Polymerase Chain Reaction Receptor, EphA4 - metabolism Receptor, EphA4 - physiology Signal Transduction X-Ray Microtomography
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