NF-κB activation-induced anti-apoptosis renders HER2-positive cells drug resistant and accelerates tumor growth

Breast cancers with HER2 overexpression are sensitive to drugs targeting the receptor or its kinase activity. HER2-targeting drugs are initially effective against HER2-positive breast cancer, but resistance inevitably occurs. We previously found that NF-κB is hyperactivated in a subset of HER2-posit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer research 2014-03, Vol.12 (3), p.408-420
Hauptverfasser:	Bailey, Shannon T, Miron, Penelope L, Choi, Yoon J, Kochupurakkal, Bose, Maulik, Gautam, Rodig, Scott J, Tian, Ruiyang, Foley, Kathleen M, Bowman, Teresa, Miron, Alexander, Brown, Myles, Iglehart, J Dirk, Debajit, K Biswas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Growth Processes - drug effects Cell Growth Processes - physiology Disease Models, Animal Drug Resistance, Neoplasm Female Humans Mice Mice, Nude NF-kappa B - genetics NF-kappa B - metabolism Quinazolines - pharmacology Receptor, ErbB-2 - genetics Signal Transduction Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!