Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase

Dynamin is a large GTPase with roles in membrane fission during clathrin-mediated endocytosis, in actin dynamics and in cytokinesis. Defects in dynamin have been linked to human diseases. The synthesis of a dynamin modulator toolkit comprising two different inhibitor classes is described. The first...

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Veröffentlicht in:	Nature protocols 2014-04, Vol.9 (4), p.851-870
Hauptverfasser:	Robertson, Mark J, Deane, Fiona M, Robinson, Phillip J, McCluskey, Adam
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/666 631/80/128 631/80/313/1461 631/92/95 Allosteric Site Amination Analytical Chemistry Biological Techniques Biology Chemistry Techniques, Synthetic Clathrin Computational Biology/Bioinformatics Cyanoacrylates - chemical synthesis Dynamins - chemistry Enzymes Genetic aspects Guanosine triphosphatase Hydrazones - chemical synthesis Indoles - chemical synthesis Life Sciences Ligands Microarrays Naphthols - chemical synthesis Organic Chemistry Physiological aspects Proteins protocol
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