Diagnosis and treatment of lymph node metastases in pediatric rhabdomyosarcoma in the Netherlands: a retrospective analysis
In pediatric rhabdomyosarcoma (RMS), evaluation of lymph node involvement (N1) is an important staging aspect, but difficult to assess. The aim of our study was to evaluate the assessment of lymph node infiltration and impact on outcome in N1 RMS patients. We identified 277 non-metastatic RMS patien...
Gespeichert in:
| Veröffentlicht in: | Journal of pediatric surgery 2014-03, Vol.49 (3), p.416-419 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 419 |
|---|---|
| container_issue | 3 |
| container_start_page | 416 |
| container_title | Journal of pediatric surgery |
| container_volume | 49 |
| creator | Terwisscha van Scheltinga, Cecilia E J Spronk, Pauline van Rosmalen, Joost Wijnen, Marc H W A Heij, Hugo A van Baren, Robertine Merks, Johannes H M van Noesel, Max M Wijnen, Rene M H |
| description | In pediatric rhabdomyosarcoma (RMS), evaluation of lymph node involvement (N1) is an important staging aspect, but difficult to assess. The aim of our study was to evaluate the assessment of lymph node infiltration and impact on outcome in N1 RMS patients.
We identified 277 non-metastatic RMS patients diagnosed and treated between 1990 and 2008. Patients with recorded N1 disease were evaluated for their diagnostic procedures and outcome.
In 13.7% N1 status was reported. In 19 of 34 N1 patients, lymph node biopsies were performed for histologically confirmation. Different treatment modalities were used to treat lymph node metastases. In total 23 of 31 patients received local treatment of the node (11/23 RT, 4/23 surgery, and 8/23 both). All patients received chemotherapy. Lymph node relapse occurred in 7 of 31 patients who were treated with one or two modalities. Only 1 (14%) of 8 patients treated with three modalities relapsed. In N0 patients 10 (4.2%) of 239 had a regional lymph node relapse, and 9 of 10 died.
Lymph node metastases are an essential part of staging. Node positivity contributes to relapse of disease. Nodal relapse is also associated with a high mortality rate. These data imply that nodal assessment needs to be optimal and standardized for improved staging. |
| doi_str_mv | 10.1016/j.jpedsurg.2013.08.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1509408069</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1509408069</sourcerecordid><originalsourceid>FETCH-LOGICAL-p211t-ae8c4220ea738a1f5cad768601c7188211ef6b73bbf35610d54900443170c153</originalsourceid><addsrcrecordid>eNo1kE9LxDAQxYMg7rr6FZYcvbROmjbNepP1Lyx62XtJ0-lulrapSSoUv7wRFYaZgXm83_AIWTNIGTBxe0pPIzZ-coc0A8ZTkClAdkaWrOAsKYCXC3Lp_QkgrsAuyCLLRQG5kEvy9WDUYbDeeKqGhgaHKvQ4BGpb2s39eKSDbZD2GJSPhZ6agUaaUcEZTd1R1Y3tZ-uV07ZXP9dwRPqGsbsuWvo7qqjD4KwfUQfziRGkujkSr8h5qzqP139zRfZPj_vtS7J7f37d3u-SMWMsJAqlzrMMUJVcKtYWWjWlkAKYLpmUUYOtqEte1y0vBIOmyDcAec5ZCTpGsCI3v7ajsx8T-lD1xmvs4ndoJ1-xAjY5SBCbKF3_Sae6x6YanemVm6v_vPg3Xp5vdA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1509408069</pqid></control><display><type>article</type><title>Diagnosis and treatment of lymph node metastases in pediatric rhabdomyosarcoma in the Netherlands: a retrospective analysis</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Terwisscha van Scheltinga, Cecilia E J ; Spronk, Pauline ; van Rosmalen, Joost ; Wijnen, Marc H W A ; Heij, Hugo A ; van Baren, Robertine ; Merks, Johannes H M ; van Noesel, Max M ; Wijnen, Rene M H</creator><creatorcontrib>Terwisscha van Scheltinga, Cecilia E J ; Spronk, Pauline ; van Rosmalen, Joost ; Wijnen, Marc H W A ; Heij, Hugo A ; van Baren, Robertine ; Merks, Johannes H M ; van Noesel, Max M ; Wijnen, Rene M H</creatorcontrib><description>In pediatric rhabdomyosarcoma (RMS), evaluation of lymph node involvement (N1) is an important staging aspect, but difficult to assess. The aim of our study was to evaluate the assessment of lymph node infiltration and impact on outcome in N1 RMS patients.
We identified 277 non-metastatic RMS patients diagnosed and treated between 1990 and 2008. Patients with recorded N1 disease were evaluated for their diagnostic procedures and outcome.
In 13.7% N1 status was reported. In 19 of 34 N1 patients, lymph node biopsies were performed for histologically confirmation. Different treatment modalities were used to treat lymph node metastases. In total 23 of 31 patients received local treatment of the node (11/23 RT, 4/23 surgery, and 8/23 both). All patients received chemotherapy. Lymph node relapse occurred in 7 of 31 patients who were treated with one or two modalities. Only 1 (14%) of 8 patients treated with three modalities relapsed. In N0 patients 10 (4.2%) of 239 had a regional lymph node relapse, and 9 of 10 died.
Lymph node metastases are an essential part of staging. Node positivity contributes to relapse of disease. Nodal relapse is also associated with a high mortality rate. These data imply that nodal assessment needs to be optimal and standardized for improved staging.</description><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/j.jpedsurg.2013.08.002</identifier><identifier>PMID: 24650468</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biopsy - methods ; Brachytherapy ; Child ; Child, Preschool ; Combined Modality Therapy ; Dactinomycin - administration & dosage ; Disease-Free Survival ; Female ; Humans ; Ifosfamide - administration & dosage ; Infant ; Infant, Newborn ; Lymph Node Excision ; Lymphatic Irradiation ; Lymphatic Metastasis - diagnosis ; Lymphatic Metastasis - radiotherapy ; Male ; Neoplasm Staging - methods ; Netherlands - epidemiology ; Proportional Hazards Models ; Recurrence ; Retrospective Studies ; Rhabdomyosarcoma - diagnosis ; Rhabdomyosarcoma - secondary ; Rhabdomyosarcoma - therapy ; Sensitivity and Specificity ; Survival Rate ; Treatment Outcome ; Vincristine - administration & dosage</subject><ispartof>Journal of pediatric surgery, 2014-03, Vol.49 (3), p.416-419</ispartof><rights>2014.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24650468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terwisscha van Scheltinga, Cecilia E J</creatorcontrib><creatorcontrib>Spronk, Pauline</creatorcontrib><creatorcontrib>van Rosmalen, Joost</creatorcontrib><creatorcontrib>Wijnen, Marc H W A</creatorcontrib><creatorcontrib>Heij, Hugo A</creatorcontrib><creatorcontrib>van Baren, Robertine</creatorcontrib><creatorcontrib>Merks, Johannes H M</creatorcontrib><creatorcontrib>van Noesel, Max M</creatorcontrib><creatorcontrib>Wijnen, Rene M H</creatorcontrib><title>Diagnosis and treatment of lymph node metastases in pediatric rhabdomyosarcoma in the Netherlands: a retrospective analysis</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>In pediatric rhabdomyosarcoma (RMS), evaluation of lymph node involvement (N1) is an important staging aspect, but difficult to assess. The aim of our study was to evaluate the assessment of lymph node infiltration and impact on outcome in N1 RMS patients.
We identified 277 non-metastatic RMS patients diagnosed and treated between 1990 and 2008. Patients with recorded N1 disease were evaluated for their diagnostic procedures and outcome.
In 13.7% N1 status was reported. In 19 of 34 N1 patients, lymph node biopsies were performed for histologically confirmation. Different treatment modalities were used to treat lymph node metastases. In total 23 of 31 patients received local treatment of the node (11/23 RT, 4/23 surgery, and 8/23 both). All patients received chemotherapy. Lymph node relapse occurred in 7 of 31 patients who were treated with one or two modalities. Only 1 (14%) of 8 patients treated with three modalities relapsed. In N0 patients 10 (4.2%) of 239 had a regional lymph node relapse, and 9 of 10 died.
Lymph node metastases are an essential part of staging. Node positivity contributes to relapse of disease. Nodal relapse is also associated with a high mortality rate. These data imply that nodal assessment needs to be optimal and standardized for improved staging.</description><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biopsy - methods</subject><subject>Brachytherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Dactinomycin - administration & dosage</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Ifosfamide - administration & dosage</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Irradiation</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Lymphatic Metastasis - radiotherapy</subject><subject>Male</subject><subject>Neoplasm Staging - methods</subject><subject>Netherlands - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Rhabdomyosarcoma - diagnosis</subject><subject>Rhabdomyosarcoma - secondary</subject><subject>Rhabdomyosarcoma - therapy</subject><subject>Sensitivity and Specificity</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Vincristine - administration & dosage</subject><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE9LxDAQxYMg7rr6FZYcvbROmjbNepP1Lyx62XtJ0-lulrapSSoUv7wRFYaZgXm83_AIWTNIGTBxe0pPIzZ-coc0A8ZTkClAdkaWrOAsKYCXC3Lp_QkgrsAuyCLLRQG5kEvy9WDUYbDeeKqGhgaHKvQ4BGpb2s39eKSDbZD2GJSPhZ6agUaaUcEZTd1R1Y3tZ-uV07ZXP9dwRPqGsbsuWvo7qqjD4KwfUQfziRGkujkSr8h5qzqP139zRfZPj_vtS7J7f37d3u-SMWMsJAqlzrMMUJVcKtYWWjWlkAKYLpmUUYOtqEte1y0vBIOmyDcAec5ZCTpGsCI3v7ajsx8T-lD1xmvs4ndoJ1-xAjY5SBCbKF3_Sae6x6YanemVm6v_vPg3Xp5vdA</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Terwisscha van Scheltinga, Cecilia E J</creator><creator>Spronk, Pauline</creator><creator>van Rosmalen, Joost</creator><creator>Wijnen, Marc H W A</creator><creator>Heij, Hugo A</creator><creator>van Baren, Robertine</creator><creator>Merks, Johannes H M</creator><creator>van Noesel, Max M</creator><creator>Wijnen, Rene M H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Diagnosis and treatment of lymph node metastases in pediatric rhabdomyosarcoma in the Netherlands: a retrospective analysis</title><author>Terwisscha van Scheltinga, Cecilia E J ; Spronk, Pauline ; van Rosmalen, Joost ; Wijnen, Marc H W A ; Heij, Hugo A ; van Baren, Robertine ; Merks, Johannes H M ; van Noesel, Max M ; Wijnen, Rene M H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-ae8c4220ea738a1f5cad768601c7188211ef6b73bbf35610d54900443170c153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biopsy - methods</topic><topic>Brachytherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Dactinomycin - administration & dosage</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Ifosfamide - administration & dosage</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Irradiation</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Lymphatic Metastasis - radiotherapy</topic><topic>Male</topic><topic>Neoplasm Staging - methods</topic><topic>Netherlands - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Rhabdomyosarcoma - diagnosis</topic><topic>Rhabdomyosarcoma - secondary</topic><topic>Rhabdomyosarcoma - therapy</topic><topic>Sensitivity and Specificity</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Vincristine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terwisscha van Scheltinga, Cecilia E J</creatorcontrib><creatorcontrib>Spronk, Pauline</creatorcontrib><creatorcontrib>van Rosmalen, Joost</creatorcontrib><creatorcontrib>Wijnen, Marc H W A</creatorcontrib><creatorcontrib>Heij, Hugo A</creatorcontrib><creatorcontrib>van Baren, Robertine</creatorcontrib><creatorcontrib>Merks, Johannes H M</creatorcontrib><creatorcontrib>van Noesel, Max M</creatorcontrib><creatorcontrib>Wijnen, Rene M H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terwisscha van Scheltinga, Cecilia E J</au><au>Spronk, Pauline</au><au>van Rosmalen, Joost</au><au>Wijnen, Marc H W A</au><au>Heij, Hugo A</au><au>van Baren, Robertine</au><au>Merks, Johannes H M</au><au>van Noesel, Max M</au><au>Wijnen, Rene M H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis and treatment of lymph node metastases in pediatric rhabdomyosarcoma in the Netherlands: a retrospective analysis</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>49</volume><issue>3</issue><spage>416</spage><epage>419</epage><pages>416-419</pages><eissn>1531-5037</eissn><abstract>In pediatric rhabdomyosarcoma (RMS), evaluation of lymph node involvement (N1) is an important staging aspect, but difficult to assess. The aim of our study was to evaluate the assessment of lymph node infiltration and impact on outcome in N1 RMS patients.
We identified 277 non-metastatic RMS patients diagnosed and treated between 1990 and 2008. Patients with recorded N1 disease were evaluated for their diagnostic procedures and outcome.
In 13.7% N1 status was reported. In 19 of 34 N1 patients, lymph node biopsies were performed for histologically confirmation. Different treatment modalities were used to treat lymph node metastases. In total 23 of 31 patients received local treatment of the node (11/23 RT, 4/23 surgery, and 8/23 both). All patients received chemotherapy. Lymph node relapse occurred in 7 of 31 patients who were treated with one or two modalities. Only 1 (14%) of 8 patients treated with three modalities relapsed. In N0 patients 10 (4.2%) of 239 had a regional lymph node relapse, and 9 of 10 died.
Lymph node metastases are an essential part of staging. Node positivity contributes to relapse of disease. Nodal relapse is also associated with a high mortality rate. These data imply that nodal assessment needs to be optimal and standardized for improved staging.</abstract><cop>United States</cop><pmid>24650468</pmid><doi>10.1016/j.jpedsurg.2013.08.002</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1531-5037 |
| ispartof | Journal of pediatric surgery, 2014-03, Vol.49 (3), p.416-419 |
| issn | 1531-5037 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1509408069 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biopsy - methods Brachytherapy Child Child, Preschool Combined Modality Therapy Dactinomycin - administration & dosage Disease-Free Survival Female Humans Ifosfamide - administration & dosage Infant Infant, Newborn Lymph Node Excision Lymphatic Irradiation Lymphatic Metastasis - diagnosis Lymphatic Metastasis - radiotherapy Male Neoplasm Staging - methods Netherlands - epidemiology Proportional Hazards Models Recurrence Retrospective Studies Rhabdomyosarcoma - diagnosis Rhabdomyosarcoma - secondary Rhabdomyosarcoma - therapy Sensitivity and Specificity Survival Rate Treatment Outcome Vincristine - administration & dosage |
| title | Diagnosis and treatment of lymph node metastases in pediatric rhabdomyosarcoma in the Netherlands: a retrospective analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T07%3A03%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnosis%20and%20treatment%20of%20lymph%20node%20metastases%20in%20pediatric%20rhabdomyosarcoma%20in%20the%20Netherlands:%20a%20retrospective%20analysis&rft.jtitle=Journal%20of%20pediatric%20surgery&rft.au=Terwisscha%20van%20Scheltinga,%20Cecilia%20E%20J&rft.date=2014-03-01&rft.volume=49&rft.issue=3&rft.spage=416&rft.epage=419&rft.pages=416-419&rft.eissn=1531-5037&rft_id=info:doi/10.1016/j.jpedsurg.2013.08.002&rft_dat=%3Cproquest_pubme%3E1509408069%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1509408069&rft_id=info:pmid/24650468&rfr_iscdi=true |