Extensive deletions and insertions in different MHC supratypes detected by pulsed field gel electrophoresis
The genomic organization of the human MHC was examined in multiple examples of six different supratypes using pulsed field electrophoresis (PFGE) after digestion of genomic DNA with infrequently cutting restriction endonucleases. Differences in restriction fragment length and band intensity were sho...
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| Veröffentlicht in: | The Journal of experimental medicine 1988-09, Vol.168 (3), p.933-940 |
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| container_end_page | 940 |
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| container_issue | 3 |
| container_start_page | 933 |
| container_title | The Journal of experimental medicine |
| container_volume | 168 |
| creator | TOKUNAGA, K SAUERACKER, G KAY, P. H CHRISTIANSEN, F. T ANAND, R DAWKINS, R. L |
| description | The genomic organization of the human MHC was examined in multiple examples of six different supratypes using pulsed field electrophoresis (PFGE) after digestion of genomic DNA with infrequently cutting restriction endonucleases. Differences in restriction fragment length and band intensity were shown to be specific for each supratype. Mapping of the MHC revealed that each supratype contains previously undescribed deletions and insertions between HLA B and DQ regions. |
| doi_str_mv | 10.1084/jem.168.3.933 |
| format | Article |
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L</creatorcontrib><title>Extensive deletions and insertions in different MHC supratypes detected by pulsed field gel electrophoresis</title><title>The Journal of experimental medicine</title><description>The genomic organization of the human MHC was examined in multiple examples of six different supratypes using pulsed field electrophoresis (PFGE) after digestion of genomic DNA with infrequently cutting restriction endonucleases. Differences in restriction fragment length and band intensity were shown to be specific for each supratype. Mapping of the MHC revealed that each supratype contains previously undescribed deletions and insertions between HLA B and DQ regions.</description><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Histocompatibility antigens (hla, h-2 and other systems)</topic><topic>Molecular immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOKUNAGA, K</creatorcontrib><creatorcontrib>SAUERACKER, G</creatorcontrib><creatorcontrib>KAY, P. H</creatorcontrib><creatorcontrib>CHRISTIANSEN, F. T</creatorcontrib><creatorcontrib>ANAND, R</creatorcontrib><creatorcontrib>DAWKINS, R. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TOKUNAGA, K</au><au>SAUERACKER, G</au><au>KAY, P. H</au><au>CHRISTIANSEN, F. T</au><au>ANAND, R</au><au>DAWKINS, R. 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Mapping of the MHC revealed that each supratype contains previously undescribed deletions and insertions between HLA B and DQ regions.</abstract><cop>New York, NY</cop><pub>Rockefeller University Press</pub><doi>10.1084/jem.168.3.933</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of experimental medicine, 1988-09, Vol.168 (3), p.933-940 |
| issn | 0022-1007 1540-9538 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15091751 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antigens Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility antigens (hla, h-2 and other systems) Molecular immunology |
| title | Extensive deletions and insertions in different MHC supratypes detected by pulsed field gel electrophoresis |
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