Site-Specific Antibody–Drug Conjugation through Glycoengineering

Antibody–drug conjugates (ADCs) have been proven clinically to be more effective anti-cancer agents than native antibodies. However, the classical conjugation chemistries to prepare ADCs by targeting primary amines or hinge disulfides have a number of shortcomings including heterogeneous product pro...

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Veröffentlicht in:	Bioconjugate chemistry 2014-03, Vol.25 (3), p.510-520
Hauptverfasser:	Zhou, Qun, Stefano, James E, Manning, Charlene, Kyazike, Josephine, Chen, Bo, Gianolio, Diego A, Park, Anna, Busch, Michelle, Bird, Julie, Zheng, Xiaoyang, Simonds-Mannes, Helene, Kim, Jennifer, Gregory, Rick C, Miller, Robert J, Brondyk, William H, Dhal, Pradeep K, Pan, Clark Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - chemistry Antibodies, Monoclonal, Humanized - chemistry Antibodies, Monoclonal, Humanized - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biochemistry Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cytotoxicity Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Glycosylation Humans Mice Mice, SCID Molecular Structure Monoclonal antibodies Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Oxidation Polysaccharides - chemistry Sialic Acids - chemistry Sialic Acids - metabolism Sialyltransferases - chemistry Sialyltransferases - metabolism Structure-Activity Relationship Trastuzumab
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