The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle

Topical 5% alpha lipoic acid (ALA) has shown efficacy in treatment of photo-damaged skin. The aim of this work was to evaluate the potential of poloxamer (P407) gel as a vehicle for the novel lipid base particulate system (cubosome dispersions) of ALA. Cubosome dispersions were formulated by two dif...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2014-02, Vol.86 (2), p.251-259
Hauptverfasser:	Sherif, Saly, Bendas, Ehab R., Badawy, Sabry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alpha lipoic acid Antioxidant Chemistry, Pharmaceutical - methods Clinical study Cosmeceutical application Cubosomes Double-Blind Method Drug release Female Gels - administration & dosage Gels - chemistry Glyceryl monooleate Humans Liquid crystals Middle Aged Nanostructures - administration & dosage Nanostructures - chemistry Particle Size Pharmaceutical Vehicles - administration & dosage Pharmaceutical Vehicles - chemistry Poloxamer - chemistry Poloxamer - therapeutic use Poloxamer gel Rheology Skin Aging - drug effects Temperature Thioctic Acid - administration & dosage Thioctic Acid - chemistry
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