Influence of Hyperoxia and Mechanical Ventilation in Lung Inflammation and Diaphragm Function in Aged Versus Adult Rats
Although assist ventilation with FIO2 0.21 is the preferable mode of ventilation in the intensive care unit, sometimes controlled ventilation with hyperoxia is needed. But the impact of this setting has not been extensively studied in elderly subjects. We hypothesized that a high fraction of inspire...
Gespeichert in:
| Veröffentlicht in: | Inflammation 2014-04, Vol.37 (2), p.486-494 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 494 |
|---|---|
| container_issue | 2 |
| container_start_page | 486 |
| container_title | Inflammation |
| container_volume | 37 |
| creator | Andrade, P. V. dos Santos, J. M. Silva, H. C. A. Wilbert, D. D. Cavassani, S. S. Oliveira-Júnior, I. S. |
| description | Although assist ventilation with FIO2 0.21 is the preferable mode of ventilation in the intensive care unit, sometimes controlled ventilation with hyperoxia is needed. But the impact of this setting has not been extensively studied in elderly subjects. We hypothesized that a high fraction of inspired oxygen (FiO
2
) and controlled mechanical ventilation (CMV) is associated with greater deleterious effects in old compared to adult subjects. Adult and old rats were submitted to CMV with low tidal volume (6 ml/kg) and FiO
2
1 during 3 or 6 h. Arterial blood gas samples were measured at 0, 60 and 180 min (four groups: old and adult rats, 3 or 6 h of CMV), and additionally at 360 min (two groups: old and adult rats, 6 h of CMV). Furthermore, total protein content (TPC) and tumor necrosis factor-alpha (TNF-α) in bronchoalveolar lavage were assessed; lung tissue was used for malondialdehyde and histological analyses, and the diaphragm for measurement of contractile function. Arterial blood gas analysis showed an initial (60 min) greater PaO
2
in elderly versus adult animals; after that time, elderly animals had lowers pH and PaO
2
, and greater PaCO
2
. After 3 h of CMV, TPC and TNF-α levels were higher in the old compared with the adult group (
P
|
| doi_str_mv | 10.1007/s10753-013-9762-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1508761879</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3238846161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-36976bc01b26a022e4e64ccef9339856e8425d91f5472f183e066842cb235bb33</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhoMo9lr9AW4k4MbNaL6TWV5a-wG3FIq6DZnMmdspM5lrMkH775thWhFB6Cpw8rzv4fAg9J6Sz5QQ_SVRoiWvCOVVrRWrxAu0oVLzikmtXqIN4YpUvK71EXqT0h0hxNSGv0ZHTFBppCYb9OsydEOG4AFPHb64P0CcfvcOu9DiK_C3LvTeDfgHhLkf3NxPAfcB73LY4yXpxnEdLvxp7w630e1HfJaDf2K3e2hLPqac8LbNw4xv3JzeoledGxK8e3yP0fezr99OLqrd9fnlyXZXeSHMXHFVDms8oQ1TjjAGApTwHrqa89pIBUYw2da0k0KzjhoORKky8w3jsmk4P0af1t5DnH5mSLMd--RhGFyAKSdLJTFaUaPr56CSSWGMKejHf9C7KcdQDlkooankTBeKrpSPU0oROnuI_ejivaXELgLtKtAWgXYRaEXJfHhszs0I7Z_Ek7ECsBVI5SvsIf61-r-tD_RNpDw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504715327</pqid></control><display><type>article</type><title>Influence of Hyperoxia and Mechanical Ventilation in Lung Inflammation and Diaphragm Function in Aged Versus Adult Rats</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Andrade, P. V. ; dos Santos, J. M. ; Silva, H. C. A. ; Wilbert, D. D. ; Cavassani, S. S. ; Oliveira-Júnior, I. S.</creator><creatorcontrib>Andrade, P. V. ; dos Santos, J. M. ; Silva, H. C. A. ; Wilbert, D. D. ; Cavassani, S. S. ; Oliveira-Júnior, I. S.</creatorcontrib><description>Although assist ventilation with FIO2 0.21 is the preferable mode of ventilation in the intensive care unit, sometimes controlled ventilation with hyperoxia is needed. But the impact of this setting has not been extensively studied in elderly subjects. We hypothesized that a high fraction of inspired oxygen (FiO
2
) and controlled mechanical ventilation (CMV) is associated with greater deleterious effects in old compared to adult subjects. Adult and old rats were submitted to CMV with low tidal volume (6 ml/kg) and FiO
2
1 during 3 or 6 h. Arterial blood gas samples were measured at 0, 60 and 180 min (four groups: old and adult rats, 3 or 6 h of CMV), and additionally at 360 min (two groups: old and adult rats, 6 h of CMV). Furthermore, total protein content (TPC) and tumor necrosis factor-alpha (TNF-α) in bronchoalveolar lavage were assessed; lung tissue was used for malondialdehyde and histological analyses, and the diaphragm for measurement of contractile function. Arterial blood gas analysis showed an initial (60 min) greater PaO
2
in elderly versus adult animals; after that time, elderly animals had lowers pH and PaO
2
, and greater PaCO
2
. After 3 h of CMV, TPC and TNF-α levels were higher in the old compared with the adult group (
P
< 0.05). After 6 h of MV, malondialdehyde was significantly higher in elderly compared with the adult animals (
P
< 0.05). Histological analysis showed leukocyte infiltration and edema, greater in old animals. In diaphragm, twitch contraction with caffeine significantly declined after 6 h of CMV only for the elderly group. These data support the hypothesis that relatively short-term CMV with low tidal volume and hyperoxia has greatest impact in elderly rats, decreasing diaphragmatic contractile function and increasing lung inflammation.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-013-9762-4</identifier><identifier>PMID: 24158570</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Age Factors ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood Gas Analysis ; Bronchoalveolar Lavage Fluid - chemistry ; Cytomegalovirus ; Diaphragm - physiopathology ; Disease Models, Animal ; Hyperoxia - blood ; Hyperoxia - complications ; Hyperoxia - immunology ; Hyperoxia - pathology ; Hyperoxia - physiopathology ; Immunology ; Inflammation Mediators - metabolism ; Internal Medicine ; Lung - immunology ; Lung - pathology ; Lung - physiopathology ; Male ; Malondialdehyde - metabolism ; Muscle Contraction ; Pathology ; Pharmacology/Toxicology ; Pneumonia, Ventilator-Associated - blood ; Pneumonia, Ventilator-Associated - etiology ; Pneumonia, Ventilator-Associated - immunology ; Pneumonia, Ventilator-Associated - pathology ; Pneumonia, Ventilator-Associated - physiopathology ; Rats ; Rats, Wistar ; Respiration, Artificial - adverse effects ; Rheumatology ; Risk Factors ; Tidal Volume ; Time Factors ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Inflammation, 2014-04, Vol.37 (2), p.486-494</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-36976bc01b26a022e4e64ccef9339856e8425d91f5472f183e066842cb235bb33</citedby><cites>FETCH-LOGICAL-c448t-36976bc01b26a022e4e64ccef9339856e8425d91f5472f183e066842cb235bb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-013-9762-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-013-9762-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24158570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andrade, P. V.</creatorcontrib><creatorcontrib>dos Santos, J. M.</creatorcontrib><creatorcontrib>Silva, H. C. A.</creatorcontrib><creatorcontrib>Wilbert, D. D.</creatorcontrib><creatorcontrib>Cavassani, S. S.</creatorcontrib><creatorcontrib>Oliveira-Júnior, I. S.</creatorcontrib><title>Influence of Hyperoxia and Mechanical Ventilation in Lung Inflammation and Diaphragm Function in Aged Versus Adult Rats</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Although assist ventilation with FIO2 0.21 is the preferable mode of ventilation in the intensive care unit, sometimes controlled ventilation with hyperoxia is needed. But the impact of this setting has not been extensively studied in elderly subjects. We hypothesized that a high fraction of inspired oxygen (FiO
2
) and controlled mechanical ventilation (CMV) is associated with greater deleterious effects in old compared to adult subjects. Adult and old rats were submitted to CMV with low tidal volume (6 ml/kg) and FiO
2
1 during 3 or 6 h. Arterial blood gas samples were measured at 0, 60 and 180 min (four groups: old and adult rats, 3 or 6 h of CMV), and additionally at 360 min (two groups: old and adult rats, 6 h of CMV). Furthermore, total protein content (TPC) and tumor necrosis factor-alpha (TNF-α) in bronchoalveolar lavage were assessed; lung tissue was used for malondialdehyde and histological analyses, and the diaphragm for measurement of contractile function. Arterial blood gas analysis showed an initial (60 min) greater PaO
2
in elderly versus adult animals; after that time, elderly animals had lowers pH and PaO
2
, and greater PaCO
2
. After 3 h of CMV, TPC and TNF-α levels were higher in the old compared with the adult group (
P
< 0.05). After 6 h of MV, malondialdehyde was significantly higher in elderly compared with the adult animals (
P
< 0.05). Histological analysis showed leukocyte infiltration and edema, greater in old animals. In diaphragm, twitch contraction with caffeine significantly declined after 6 h of CMV only for the elderly group. These data support the hypothesis that relatively short-term CMV with low tidal volume and hyperoxia has greatest impact in elderly rats, decreasing diaphragmatic contractile function and increasing lung inflammation.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Gas Analysis</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Cytomegalovirus</subject><subject>Diaphragm - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Hyperoxia - blood</subject><subject>Hyperoxia - complications</subject><subject>Hyperoxia - immunology</subject><subject>Hyperoxia - pathology</subject><subject>Hyperoxia - physiopathology</subject><subject>Immunology</subject><subject>Inflammation Mediators - metabolism</subject><subject>Internal Medicine</subject><subject>Lung - immunology</subject><subject>Lung - pathology</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Muscle Contraction</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Pneumonia, Ventilator-Associated - blood</subject><subject>Pneumonia, Ventilator-Associated - etiology</subject><subject>Pneumonia, Ventilator-Associated - immunology</subject><subject>Pneumonia, Ventilator-Associated - pathology</subject><subject>Pneumonia, Ventilator-Associated - physiopathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Respiration, Artificial - adverse effects</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Tidal Volume</subject><subject>Time Factors</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1rFTEUhoMo9lr9AW4k4MbNaL6TWV5a-wG3FIq6DZnMmdspM5lrMkH775thWhFB6Cpw8rzv4fAg9J6Sz5QQ_SVRoiWvCOVVrRWrxAu0oVLzikmtXqIN4YpUvK71EXqT0h0hxNSGv0ZHTFBppCYb9OsydEOG4AFPHb64P0CcfvcOu9DiK_C3LvTeDfgHhLkf3NxPAfcB73LY4yXpxnEdLvxp7w630e1HfJaDf2K3e2hLPqac8LbNw4xv3JzeoledGxK8e3yP0fezr99OLqrd9fnlyXZXeSHMXHFVDms8oQ1TjjAGApTwHrqa89pIBUYw2da0k0KzjhoORKky8w3jsmk4P0af1t5DnH5mSLMd--RhGFyAKSdLJTFaUaPr56CSSWGMKejHf9C7KcdQDlkooankTBeKrpSPU0oROnuI_ejivaXELgLtKtAWgXYRaEXJfHhszs0I7Z_Ek7ECsBVI5SvsIf61-r-tD_RNpDw</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Andrade, P. V.</creator><creator>dos Santos, J. M.</creator><creator>Silva, H. C. A.</creator><creator>Wilbert, D. D.</creator><creator>Cavassani, S. S.</creator><creator>Oliveira-Júnior, I. S.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Influence of Hyperoxia and Mechanical Ventilation in Lung Inflammation and Diaphragm Function in Aged Versus Adult Rats</title><author>Andrade, P. V. ; dos Santos, J. M. ; Silva, H. C. A. ; Wilbert, D. D. ; Cavassani, S. S. ; Oliveira-Júnior, I. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-36976bc01b26a022e4e64ccef9339856e8425d91f5472f183e066842cb235bb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Gas Analysis</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Cytomegalovirus</topic><topic>Diaphragm - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Hyperoxia - blood</topic><topic>Hyperoxia - complications</topic><topic>Hyperoxia - immunology</topic><topic>Hyperoxia - pathology</topic><topic>Hyperoxia - physiopathology</topic><topic>Immunology</topic><topic>Inflammation Mediators - metabolism</topic><topic>Internal Medicine</topic><topic>Lung - immunology</topic><topic>Lung - pathology</topic><topic>Lung - physiopathology</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Muscle Contraction</topic><topic>Pathology</topic><topic>Pharmacology/Toxicology</topic><topic>Pneumonia, Ventilator-Associated - blood</topic><topic>Pneumonia, Ventilator-Associated - etiology</topic><topic>Pneumonia, Ventilator-Associated - immunology</topic><topic>Pneumonia, Ventilator-Associated - pathology</topic><topic>Pneumonia, Ventilator-Associated - physiopathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Respiration, Artificial - adverse effects</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Tidal Volume</topic><topic>Time Factors</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andrade, P. V.</creatorcontrib><creatorcontrib>dos Santos, J. M.</creatorcontrib><creatorcontrib>Silva, H. C. A.</creatorcontrib><creatorcontrib>Wilbert, D. D.</creatorcontrib><creatorcontrib>Cavassani, S. S.</creatorcontrib><creatorcontrib>Oliveira-Júnior, I. S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrade, P. V.</au><au>dos Santos, J. M.</au><au>Silva, H. C. A.</au><au>Wilbert, D. D.</au><au>Cavassani, S. S.</au><au>Oliveira-Júnior, I. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Hyperoxia and Mechanical Ventilation in Lung Inflammation and Diaphragm Function in Aged Versus Adult Rats</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>37</volume><issue>2</issue><spage>486</spage><epage>494</epage><pages>486-494</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>Although assist ventilation with FIO2 0.21 is the preferable mode of ventilation in the intensive care unit, sometimes controlled ventilation with hyperoxia is needed. But the impact of this setting has not been extensively studied in elderly subjects. We hypothesized that a high fraction of inspired oxygen (FiO
2
) and controlled mechanical ventilation (CMV) is associated with greater deleterious effects in old compared to adult subjects. Adult and old rats were submitted to CMV with low tidal volume (6 ml/kg) and FiO
2
1 during 3 or 6 h. Arterial blood gas samples were measured at 0, 60 and 180 min (four groups: old and adult rats, 3 or 6 h of CMV), and additionally at 360 min (two groups: old and adult rats, 6 h of CMV). Furthermore, total protein content (TPC) and tumor necrosis factor-alpha (TNF-α) in bronchoalveolar lavage were assessed; lung tissue was used for malondialdehyde and histological analyses, and the diaphragm for measurement of contractile function. Arterial blood gas analysis showed an initial (60 min) greater PaO
2
in elderly versus adult animals; after that time, elderly animals had lowers pH and PaO
2
, and greater PaCO
2
. After 3 h of CMV, TPC and TNF-α levels were higher in the old compared with the adult group (
P
< 0.05). After 6 h of MV, malondialdehyde was significantly higher in elderly compared with the adult animals (
P
< 0.05). Histological analysis showed leukocyte infiltration and edema, greater in old animals. In diaphragm, twitch contraction with caffeine significantly declined after 6 h of CMV only for the elderly group. These data support the hypothesis that relatively short-term CMV with low tidal volume and hyperoxia has greatest impact in elderly rats, decreasing diaphragmatic contractile function and increasing lung inflammation.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24158570</pmid><doi>10.1007/s10753-013-9762-4</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3997 |
| ispartof | Inflammation, 2014-04, Vol.37 (2), p.486-494 |
| issn | 0360-3997 1573-2576 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1508761879 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Age Factors Animals Biomedical and Life Sciences Biomedicine Blood Gas Analysis Bronchoalveolar Lavage Fluid - chemistry Cytomegalovirus Diaphragm - physiopathology Disease Models, Animal Hyperoxia - blood Hyperoxia - complications Hyperoxia - immunology Hyperoxia - pathology Hyperoxia - physiopathology Immunology Inflammation Mediators - metabolism Internal Medicine Lung - immunology Lung - pathology Lung - physiopathology Male Malondialdehyde - metabolism Muscle Contraction Pathology Pharmacology/Toxicology Pneumonia, Ventilator-Associated - blood Pneumonia, Ventilator-Associated - etiology Pneumonia, Ventilator-Associated - immunology Pneumonia, Ventilator-Associated - pathology Pneumonia, Ventilator-Associated - physiopathology Rats Rats, Wistar Respiration, Artificial - adverse effects Rheumatology Risk Factors Tidal Volume Time Factors Tumor Necrosis Factor-alpha - metabolism |
| title | Influence of Hyperoxia and Mechanical Ventilation in Lung Inflammation and Diaphragm Function in Aged Versus Adult Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T10%3A52%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20Hyperoxia%20and%20Mechanical%20Ventilation%20in%20Lung%20Inflammation%20and%20Diaphragm%20Function%20in%20Aged%20Versus%20Adult%20Rats&rft.jtitle=Inflammation&rft.au=Andrade,%20P.%20V.&rft.date=2014-04-01&rft.volume=37&rft.issue=2&rft.spage=486&rft.epage=494&rft.pages=486-494&rft.issn=0360-3997&rft.eissn=1573-2576&rft.coden=INFLD4&rft_id=info:doi/10.1007/s10753-013-9762-4&rft_dat=%3Cproquest_cross%3E3238846161%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1504715327&rft_id=info:pmid/24158570&rfr_iscdi=true |