Mechanical behaviour of electrospun fibre-reinforced hydrogels
Mechanically robust and biomimicking scaffolds are needed for structural engineering of tissues such as the intervertebral disc, which are prone to failure and incapable of natural healing. Here, the formation of thick, randomly aligned polycaprolactone electrospun fibre structures infiltrated with...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2014-03, Vol.25 (3), p.681-690 |
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| creator | Strange, Daniel G. T. Tonsomboon, Khaow Oyen, Michelle L. |
| description | Mechanically robust and biomimicking scaffolds are needed for structural engineering of tissues such as the intervertebral disc, which are prone to failure and incapable of natural healing. Here, the formation of thick, randomly aligned polycaprolactone electrospun fibre structures infiltrated with alginate is reported. The composites are characterised using both indentation and tensile testing and demonstrate substantially different tensile and compressive moduli. The composites are mechanically robust and exhibit large strains-to-failure, exhibiting toughening mechanisms observed in other composite material systems. The method presented here provides a way to create large-scale biomimetic scaffolds that more closely mimic the composite structure of natural tissue, with tuneable tensile and compressive properties via the fibre and matrix phases, respectively. |
| doi_str_mv | 10.1007/s10856-013-5123-y |
| format | Article |
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The method presented here provides a way to create large-scale biomimetic scaffolds that more closely mimic the composite structure of natural tissue, with tuneable tensile and compressive properties via the fibre and matrix phases, respectively.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-013-5123-y</identifier><identifier>PMID: 24408274</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Alginates - chemistry ; Biological and medical sciences ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Biomimetic Materials - chemical synthesis ; Biomimetics ; Ceramics ; Chemistry and Materials Science ; Composites ; Compressive Strength ; Elastic Modulus ; Electrochemistry - methods ; Glass ; Glucuronic Acid - chemistry ; Hardness ; Hexuronic Acids - chemistry ; Hydrogels ; Hydrogels - chemistry ; Materials Science ; Materials Testing ; Medical sciences ; Natural Materials ; Polyesters - chemistry ; Polymer Sciences ; Regenerative Medicine/Tissue Engineering ; Rotation ; Stress, Mechanical ; Surfaces and Interfaces ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Tensile Strength ; Thin Films ; Tissue engineering</subject><ispartof>Journal of materials science. 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T.</creatorcontrib><creatorcontrib>Tonsomboon, Khaow</creatorcontrib><creatorcontrib>Oyen, Michelle L.</creatorcontrib><title>Mechanical behaviour of electrospun fibre-reinforced hydrogels</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Mechanically robust and biomimicking scaffolds are needed for structural engineering of tissues such as the intervertebral disc, which are prone to failure and incapable of natural healing. Here, the formation of thick, randomly aligned polycaprolactone electrospun fibre structures infiltrated with alginate is reported. The composites are characterised using both indentation and tensile testing and demonstrate substantially different tensile and compressive moduli. The composites are mechanically robust and exhibit large strains-to-failure, exhibiting toughening mechanisms observed in other composite material systems. The method presented here provides a way to create large-scale biomimetic scaffolds that more closely mimic the composite structure of natural tissue, with tuneable tensile and compressive properties via the fibre and matrix phases, respectively.</description><subject>Alginates - chemistry</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Biomimetic Materials - chemical synthesis</subject><subject>Biomimetics</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Compressive Strength</subject><subject>Elastic Modulus</subject><subject>Electrochemistry - methods</subject><subject>Glass</subject><subject>Glucuronic Acid - chemistry</subject><subject>Hardness</subject><subject>Hexuronic Acids - chemistry</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Materials Science</subject><subject>Materials Testing</subject><subject>Medical sciences</subject><subject>Natural Materials</subject><subject>Polyesters - chemistry</subject><subject>Polymer Sciences</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Rotation</subject><subject>Stress, Mechanical</subject><subject>Surfaces and Interfaces</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Tensile Strength</subject><subject>Thin Films</subject><subject>Tissue engineering</subject><issn>0957-4530</issn><issn>1573-4838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0U1rGzEQBmAREmLHzQ_oJSyEQi5KRytpJV0KJTQf4NJLexZaaTZes951JW_A_75y7SYlEMhJBz0z0sxLyEcG1wxAfU4MtKwoME4lKzndHpEpk4pTobk-JlMwUlEhOUzIWUpLABBGylMyKYUAXSoxJV--o1-4vvWuK2pcuKd2GGMxNAV26DdxSOuxL5q2jkgjtn0zRI-hWGxDHB6xSx_ISeO6hOeHc0Z-3X77eXNP5z_uHm6-zqkXqtxQrx0XrKyaEMDUKKEyqgwscEAUztWVBOF5cFgZ7UwwVVU3xikomWECROAzcrXvu47D7xHTxq7a5LHrXI_DmCyToJU0ulLvoUJxJdSOXr6iyzx9nwf5qxhwyWRWbK98XkeK2Nh1bFcubi0Du8vB7nOwOQe7y8Fuc83FofNYrzA8V_xbfAafDsClvPsmut636cXlfpIbnV25dylf9Y8Y__vim6__Aa29nsQ</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Strange, Daniel G. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strange, Daniel G. T.</au><au>Tonsomboon, Khaow</au><au>Oyen, Michelle L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical behaviour of electrospun fibre-reinforced hydrogels</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>25</volume><issue>3</issue><spage>681</spage><epage>690</epage><pages>681-690</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Mechanically robust and biomimicking scaffolds are needed for structural engineering of tissues such as the intervertebral disc, which are prone to failure and incapable of natural healing. Here, the formation of thick, randomly aligned polycaprolactone electrospun fibre structures infiltrated with alginate is reported. The composites are characterised using both indentation and tensile testing and demonstrate substantially different tensile and compressive moduli. The composites are mechanically robust and exhibit large strains-to-failure, exhibiting toughening mechanisms observed in other composite material systems. The method presented here provides a way to create large-scale biomimetic scaffolds that more closely mimic the composite structure of natural tissue, with tuneable tensile and compressive properties via the fibre and matrix phases, respectively.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24408274</pmid><doi>10.1007/s10856-013-5123-y</doi><tpages>10</tpages></addata></record> |
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| subjects | Alginates - chemistry Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Biomimetic Materials - chemical synthesis Biomimetics Ceramics Chemistry and Materials Science Composites Compressive Strength Elastic Modulus Electrochemistry - methods Glass Glucuronic Acid - chemistry Hardness Hexuronic Acids - chemistry Hydrogels Hydrogels - chemistry Materials Science Materials Testing Medical sciences Natural Materials Polyesters - chemistry Polymer Sciences Regenerative Medicine/Tissue Engineering Rotation Stress, Mechanical Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tensile Strength Thin Films Tissue engineering |
| title | Mechanical behaviour of electrospun fibre-reinforced hydrogels |
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